In vitro antioxidant potential of linolenyl alcohol isolated from Cayratia trifolia L.
Abstract
Cayratia trifolia, a plant rich in bioactive compounds, has been known for its diverse pharmacological properties, including antioxidant activity. In this study, we focus on linolenyl alcohol, a compound isolated from Cayratia trifolia, and investigate its antioxidant potential through in vitro analysis. Linolenyl alcohol was extracted from Cayratia trifolia leaves using standard extraction techniques and characterized using spectroscopic methods. The antioxidant activity of linolenyl alcohol was evaluated using well-established antioxidant assays. The results explored significant antioxidant activity of linolenyl alcohol, with dose-dependent scavenging of free radicals observed in all assays. Overall, our findings highlight the antioxidant potential of linolenyl alcohol from Cayratia trifolia, suggesting its utility as a natural antioxidant agent in pharmaceutical and nutraceutical applications. Further investigations are warranted to explore its therapeutic benefits and potential clinical applications.
Keywords:
Cayratia trifolia, Linolenyl alcohol, Antioxidant activity, In-vitro analysisDOI
https://doi.org/10.25004/IJPSDR.2024.160406References
Ramasubburayan R, Sumathi S, Magi Bercy D, Immanuel G, Palavesam A. Antimicrobial, antioxidant and anticancer activities of mangrove associated bacterium Bacillus subtilis subsp. subtilis RG. Biocatalysis and Agricultural Biotechnology. 2015; 4(2): 158-165. Available from: doi.org/10.1016/j.bcab.2015.01.004
Perumal PC, Sowmya S, Velmurugan D, Sivaraman T, Gopalakrishnan VK. Assessment of dual inhibitory activity of epifriedelanol isolated from Cayratia trifolia against ovarian cancer. Bangladesh Journal of Pharmacology. 2016; 11(2): 545-551. Available from: doi.org/10.3329/bjp.v11i2.24933
Perumal PC, Sowmya S, Pratibha P, Vidya B, Anusooriya P, Starlin T, Vasanth R, Sharmila DJS, Gopalakrishnan VK. Identification of novel PPARγ agonist from GC-MS analysis of ethanolic extract of Cayratia trifolia (L.): a computational molecular simulation studies. Journal of Applied Pharmaceutical Science. 2014; 4(9): 6-11. Available from: doi.org/10.7324/JAPS.2014.40902
Pei J, Yan Y, Jayaraman S, Rajagopal P, Natarajan PM, Umapathy VR, Gopathy S, Roy JR, Sadagopan CS, Thalamati D, Palanisamy CP, Mironescu M. A review on advancements in the application of starch-based nanomaterials in biomedicine: Precision drug delivery and cancer therapy. International Journal of Biological Macromolecules. 2024; 265: 130746. Available from: doi.org/10.1016/j.ijbiomac.2024.130746
Alugoju P, Palanisamy CP, Anthikapalli NVA, Jayaraman S, Prasanskulab A, Chuchawankul S, Dyavaiah M, Tencomnao T. Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review. F1000Research. 2023; 12: 1265. Available from: doi.org/10.12688/f1000research.141669.1
Lavanya M, Krishnamoorthy R, Alshuniaber MA, Manoharadas S, Palanisamy CP, Veeraraghavan VP, Jayaraman S, Rajagopal P, Padmini R. Formulation, characterization and evaluation of gelatin-syringic acid/zinc oxide nanocomposite for its effective anticancer, antioxidant and anti-inflammatory activities. Journal of King Saud University-Science. 2023; 35: 102909. Available from: doi.org/10.1016/j.jksus.2023.102909
Sundaram S, Palanisamy CP, Subban R, Palanirajan A, Piramanayagam S, Eswaran M, Krishna CK, Kanniappan VG. 1-Pentacosanol Isolated from Stem Ethanolic Extract of Cayratia trifolia (L.) is A Potential Target for Prostate Cancer-In silico Approach. Jordan Journal of Biological Sciences. 2021; 14 (2): 359-365. Available from: doi.org/10.54319/jjbs/140223
Palanisamy CP, Pethanan S, Vincent GG, Murugesan K, Ramachandran A, Sivanandam R, Panagal M. Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells. Bioinformation. 2021; 17(8): 710-714. Available from: doi.org/10.6026/97320630017710
Bhuvaneswari M, Palanisamy CP, Mani P. Antioxidant, antimicrobial and cytotoxicity potential of n-hexane extract of Cayratia trifolia L. Bioinformation. 2021; 17(3): 452-459. Available from: doi.org/10.6026/97320630017452
Meganathan B, Panagal M. Starch-based electrospun nanofibrous scaffold incorporated with bioactive compound from cayratia trifolia promotes wound healing by activating VEGF and PDGF signaling pathways. Applied Biological Research. 2023, 25(4): 437-446. Available from: doi.org/10.5958/0974-4517.2023.00049.6
Nandakumar N, Jayaprakash R, Rengarajan T, Ramesh V, Balasubramanian MP. Hesperidin, a natural citrus flavonoglycoside, normalizes lipid peroxidation and membrane bound marker enzymes in 7, 12-Dimethylbenz (a) anthracene induced experimental breast cancer rats. Biomedicine & Preventive Nutrition. 2011; 1(4): 255-262. Available from: doi.org/10.1016/j.bionut.2011.06.004
Pham HNT, Sakoff JA, Vuong Q Van, Bowyer MC, Scarlett CJ. Screening phytochemical content, antioxidant, antimicrobial and cytotoxic activities of Catharanthus roseus (L.) G. Don stem extract and its fractions. Biocatalysis and Agricultural Biotechnology. 2018; 16: 405-411. Available from: doi.org/10.1016/j.bcab.2018.09.005
Elizabeth K, Rao MNA. Oxygen radical scavenging activity of curcumin. International Journal of Pharmaceutics. 1990; 58(3): 237-240. Available from: doi.org/10.1016/0378-5173(90)90201-E
Oyaizu M. Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine. The Japanese Journal of Nutrition and Dietetics. 1986; 44(6): 307-315. Available from: doi.org/10.5264/eiyogakuzashi.44.307
Chakraborthy GS, Ghorpade PM. Free radical scavenging activity of Abutilon indicum (Linn) sweet stem extracts. International Journal of ChemTech Research. 2010; 2(1): 526-531. Available from: doi.org/10.54319/ijctr/140672
Palanisamy CP, Kanakasabapathy D, Ashafa AOT. In vitro antioxidant potential of Euclea crispa (Thunb.) leaf extracts. Pharmacognosy Research. 2018; 10(3): 296-300. Available from: doi.org/10.4103/pr.pr_123_17
Esmaeili A, Khakpoor M. Biological activities and chemical composition of solvent extracts of Stoechospermum marginatum (C. Agardh). Acta biochimica Polonica. 2012; 59(4): 581-585. Available from: doi.org/10.1016/j.fct.2009.04.043
Ranković BR, Kosanić MM, Stanojković TP. Antioxidant, antimicrobial and anticancer activity of the lichens Cladonia furcata, Lecanora atra and Lecanora muralis. BMC Complementary Medicine and Therapies. 2011; 11: 9. Available from: doi.org/10.1186/1472-6882-11-97
Gopalakrishnan V, Perumal P, Sowmya S, Pratibha P, Vidya B, Anusooriya P, Starlin T, Ravi S, Gopalakrishnan VK. Isolation, structural characterization and in silico drug-like properties prediction of a natural compound from the ethanolic extract of Cayratia trifolia (L.). Pharmacognosy Research. 2015; 7(1): 121-125. Available from: doi.org/10.4103/0974-8490.147226
Palanisamy CP, Poompradub S, Sansanaphongpricha K, Jayaraman S, Subramani K, Sonsudin F. Biosynthesis of silver nanoparticles (AgNPs) using ethanolic extract of Nigella sativa (L.) seeds promotes wound healing via PDGF and VEGF signalling pathways activation. Biocatalysis and Agricultural Biotechnology. 2023; 54: 102970. Available from: doi.org/10.1016/j.bcab.2023.102970
Published
Abstract Display: 485 
PDF Downloads: 455 How to Cite
Issue
Section
Copyright (c) 2024 Bhuvaneswari Meganathan, Mani Panagal
This work is licensed under a Creative Commons Attribution 4.0 International License.
