Exploring Quality of Life Among Thyroid Patients in South Indian Communities: A Comprehensive Study

Authors

  • Babiker Bashir Haroun Baraka Department of Pharmacology, KLE College of Pharmacy, Rajajinagar, Bangalore-560010, Karnataka, India
  • Kalavati Jambigi Department of Pharmacology, KLE College of Pharmacy, Rajajinagar, Bangalore-560010, Karnataka, India
  • Neha Gopal PG Department of Pharmacology, KLE College of Pharmacy, Rajajinagar, Bangalore-560010, Karnataka, India
  • Shivani Verma R Department of Pharmacology, KLE College of Pharmacy, Rajajinagar, Bangalore-560010, Karnataka, India
  • Sahana S Department of Pharmacology, KLE College of Pharmacy, Rajajinagar, Bangalore-560010, Karnataka, India
  • Kapase Akshata Sidaray Department of Pharmacology, KLE College of Pharmacy, Rajajinagar, Bangalore-560010, Karnataka, India

Abstract

The thyroid gland plays a crucial role in regulating metabolism and influencing a wide range of physiological functions through its hormone production, and thyroid disorders affect millions globally, significantly impacting individuals’ quality of life and overall health. Complications arising from thyroid diseases can vary widely, affecting both physical and emotional well-being, making a comprehensive evaluation of associated complications and quality of life essential. The primary objectives of this study were to evaluate complications related to thyroid disease and assess health-related quality of life in patients with thyroid disorders, while secondary objectives included addressing safety outcomes and providing structured guidance for newly diagnosed patients to counter misinformation and improve understanding of symptoms, causes, and treatments. Conducted at the Centre of Diabetes and Endocrine Care with ethical approval from the Pranav Diabetes Centre Ethics Committee and informed consent from all participants, the study employed a systematic search strategy to identify relevant data and evaluated patients through regular clinical and biochemical assessments. Data were analysed using Chi-square statistical tests to determine significance, and demographic factors such as marital status, residency, age, gender, weight gain, hair loss, and swallowing difficulties were examined. Quality of life evaluations revealed notable variations among thyroid patients, significantly affecting their physical and emotional well-being. The study highlighted higher occurrences of thyroid disorders among married individuals, urban residents, and non-working participants within the South Indian community, with common symptoms including weight changes, temperature sensitivity, fatigue, and variable swallowing difficulties. Factors such as healthcare access, socio-cultural influences, and treatment effectiveness were found to play crucial roles in patient well-being, underscoring the importance of tailored interventions and support systems to enhance quality of life. This research emphasizes the need for clear, structured information in research articles to guide newly diagnosed patients, helping them understand thyroid symptoms, causes, and treatments and ultimately improving their overall quality of life.

Keywords:

Diagnosis and treatment for Thyroid Disorders, Quality of life (Qol), South Indian community, thyroid hormone, comprehensive study

DOI

https://doi.org/10.25004/IJPSDR.2025.170602

References

Waugh A, Grant A. Ross and Wilson: Anatomy and Physiology in Health and Illness. 12th ed. Edinburgh: Churchill Livingstone; 2014.

Tripathi KD. Essentials of Medical Pharmacology. 7th ed. New Delhi: Jaypee Brothers Medical Publishers; 2013.

Laura B K, Sarah A S, Juan D R, Aaron J B, Aiman A A, Ryan F D, Andi D P, and Eneko L N. Journal of Drug Delivery Science and Technology (87) 2023 Page no:104861.

Ramezani M, Reisian M, Sajadi Hezaveh Z. The effect of symbiotic supplementation on hypothyroidism: A randomized double-blind placebo-controlled clinical trial. PLoS One. 2023;18(3): e0278312.

Gunnarsdóttir I, Brantsæter AL. Iodine: a scoping review for Nordic Nutrition Recommendations 2023. Food Nutr Res. 2023;67:10369.

Decrane R, Stoker T, Murr A, Ford J, El-Masri H. Cross-species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models. Current Research Toxicology.

Taylor PN, Albrecht D, Scholz A, Gutierrez-Buey G, Lazarus JH, Dayan CM, Okosieme OE. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018 May;14(5):301-316. doi: 10.1038/nrendo.2018.18. Epub 2018 Mar 23. PMID: 29569622.

Nilkantham S, Majumdar V, Singh A. Scientific yoga module for hypothyroidism: A study protocol for tele-yoga RCT. Contemporary Clinical Trials Communications. 2023; 36:100573

Rabbani E, Golgiri F, Janani L, Moradi N, Fallah S, Abiri B, Vafa M. Randomized study of the effects of zinc, vitamin A, and magnesium co-supplementation on thyroid function, oxidative stress, and hs-CRP in patients with hypothyroidism. [Published 07 January 2021]. Volume 199, pages 4074–4083.

Carlé A, Krejbjerg A, Laurberg P. Epidemiology of nodular goitre: Influence of iodine intake. Best Pract Res Clin Endocrinol Metab. 2014; 28(4):465-79. Doi: 10.1016/j.beem.2014.01.001. PMID: 25047199.

Sorensen JR, Bonnema SJ, Godballe C. The impact of goiter and thyroid surgery on goiter-related esophageal dysfunction. Front Endocrinol (Lausanne). 2018; 9:679S.

Sorensen JR, Lauridsen JF, Døssing H, et al. Thyroidectomy improves tracheal anatomy and airflow in patients with nodular goiter: a prospective cohort study. Eur Thyroid J. 2017; 6(6):307-314...

Sorensen JR, Printz T, Iwarsson J, et al. The impact of post-thyroidectomy paresis on quality of life in patients with nodular thyroid disease. Otolaryngol Head Neck Surg. 2019;161(4):589-597.

Mishra A, Sabaretnam M, Chand G, et al. Quality of life (QoL) in patients with benign thyroid goiters (pre- and post-thyroidectomy): a prospective study. World J Surg. 2013;37(10):2322-2329.

Wiersinga WM, Duntas L, Fadeyev V, Nygaard B, Vanderpump MP. 2012ETA Guidelines: The Use of L-T4 + L-T3 in the Treatment of Hypothyroidism. Eur Thyroid J (2012) 1(2):55–71. doi: 10.1159/000339444.

Bjerkreim BA, Hammerstad SS, Gulseth HL, Berg TJ, Omdal LJ, Lee-Ødegård S, Eriksen EF. Effect of Liothyronine Treatment on Quality of Life in Female Hypothyroid Patients with Residual Symptoms on Levothyroxine Therapy: A Randomized Crossover Study. Front Endocrinol. 2022 Feb 22; 13:816566. Doi: 10.3389/fendo.2022.816566.

Li X, Meng Z, Jia Q, Ren X. Effect of L-thyroxine treatment versus a placebo on serum lipid levels in patients with sub-clinical hypothyroidism. Biomed Rep. 2016;5(4):443-9. Doi: 10.3892/br.2016.745.

Bakdounes A, Bakdounes D, Akashe N, Mohsen F, Alchallah MO, Alolabi H, Darjazini Nahas L. Prevalence of Ménière's Disease in Syrian patients with hypothyroidism: Cross-sectional study. Ann Med Surg (Lond). 2022;81:104405.

Thorsen RT, Døssing H, Bonnema SJ et al. The Impact of Post-Thyroidectomy Neck Stretching Exercises on Neck Discomfort, Pressure Symptoms, Voice and Quality of Life: A Randomized Controlled Trial. World J Surg 46, 2212–2222 (2022). https://doi.org/10.1007/s00268-022-06610-0

Lucaccioni L, Ficara M, Ceccarelli V, Berardi A, Predieri B, Iughetti L. Long-term outcomes of infants born to mothers with thyroid dysfunction during pregnancy. Acta Biomed. 2021;92(1) Doi: 10.23750/abm.v92i1.9696.

Jonklaas J, Bianco AC. Enhancing the patient voice: Quality of life, satisfaction, and preference during treatment of hypothyroidism. Thyroid. 2022;32(10):1139-41. Doi: 10.1089/thy. 2022.0483. PMID: 36136911; PMCID: PMC9836669.

Wildisen L, Feller M, Del Giovane C, Moutzouri E, Du Puy RS, Mooijaart SP, Collet TH, Poortvliet RKE, Kearney P, Quinn TJ, Klöppel S, Bauer DC, Peeters RP, Westendorp R, Aujesky D, Gussekloo J, Rodondi N. Effect of levothyroxine therapy on the development of depressive symptoms in older adults with subclinical hypothyroidism: An ancillary study of a randomized clinical trial. JAMA Netw Open. 2021;4(2) Doi: 10.1001/jamanetworkopen.2020.36645. PMID: 33566107; PMCID: PMC7876592.

Bianchi GP, Zaccheroni V, Solaroli E, Vescini F, Cerutti R, Zoli M, et al. Health-related quality of life in patients with thyroid disorders. Qual Life Res. 2004;13(1):45-54. doi: 10.1023/B.0000015315.35184.66.

Watt T, Groenvold M, Rasmussen AK, Bonnema SJ, Hegedüs L, Bjorner JB, et al. Quality of life in patients with benign thyroid disorders. A review. Eur J Endocrinol. 2006;154(4):501-510. doi: 10.1530/eje.1.02124.

Mentuccia D, Proietti-Pannunzi L, Tanner K, Bacci V, Pollin TI, Poehlman ET, et al. Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor. Diabetes. 2002;51(3):880-883. doi: 10.2337/diabetes.51.3.880.

Joffe RT, Brimacombe M, Levitt AJ, Stagnaro-Green A. Treatment of clinical hypothyroidism with thyroxine and triiodothyronine: a literature review and metaanalysis. Psychosomatics. 2007;48(5):379-384. doi: 10.1176/appi.psy.48.5.379.

Leonardi D, Polizzotti N, Carta A, et al. Longitudinal study of thyroid function in children with mild hyperthyrotropinemia at neonatal screening for congenital hypothyroidism. J Clin Endocrinol Metab. 2008;93(7):2679-2685.

Oren A, Wang MK, Brnjac L, Mahmud FH, Palmert MR. Mild neonatal hyperthyrotrophinaemia: 10-year experience suggests the condition is increasingly common but often transient, Clin Endocrinol. 2013; 79:832–837.

Päkkilä F, Männistö T, Surcel HM et al. Maternal thyroid dysfunction during pregnancy and thyroid function of her child in adolescence. J Clin Endocrinol Metab. 2013; 98:965–972.

Mandel SJ, Hermos RJ, Larson CA et al. Atypical hypothyroidism and the very low birthweight infant. Thyroid. 2000; 10: 693–695.

Skjoldebrand L, Brundin J, Carlstrom A, Petterson T. Thyroid-associated components in serum during normal pregnancy. Acta Endocrinol. 1982; 100:504–511.Stagnaro-Green A, Abalovich M, Alexander E et al. Guide.

Biondi B, Cappola AR, Cooper DS. Subclinical hypothyroidism: a review.JAMA. 2019;322(2):153-160. doi:10.1001/jama.2019.9052.

Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study Arch Intern Med. 2000;160(4):526-534. doi:10.1001/archinte.. 160.4.526.

Cooper DS, Biondi B. Subclinical thyroid disease. Lancet. 2012;379(9821):1142-1154. doi:10.1016/S0140-6736(11)60276-6.

Biondi B, Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008; 29(1):76-131.doi:10.1210/er.2006-0043.

Bekkering GE, Agoritsas T, Lytvyn L, et al. Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline. BMJ. 2019; 365:l2006. doi:10.1136/bmj.l2006.

Stott DJ, Rodondi N, Kearney PM, et al; TRUST Study Group. Thyroid hormone therapy for older adults with subclinical hypothyroidism. N Engl J Med. 2017;376(26):2534-2544. doi:10.1056/NEJMoa1603825.

Feller M, Snel M, Moutzouri E, et al. Association of thyroid hormone therapy with quality of life and thyroid-related symptoms in patients with subclinical hypothyroidism: a systematic review and meta-analysis.JAMA.2018;320(13):1349-1359. doi:10.1001/jama.2018.13770.

Onklaas J, Bianco AC, Bauer AJ, et al; American Thyroid Association Task Force on Thyroid Hormone Replacement. Guidelines for the treatment of hypothyroidism: prepared by the American Thyroid Association Task Force on thyroid hormone replacement. Thyroid. 2014;24(12):1670-1751. doi:10.1089/. thy 2014.0028.

Pearce SH, Brabant G, Duntas LH, Monzani F, Peeters RP, Razvi S, Wemeau JL. 2013 ETA Guideline: Management of Subclinical Hypothyroidism. Eur Thyroid J. 2013 Dec;2(4):215-28. doi: 10.1159/000356507. Epub 2013 Nov 27. PMID: 24783053; PMCID: PMC3923601.

Rodriguez-Gutierrez R, Maraka S, Ospina NS, Montori VM, Brito JP. Levothyroxine overuse: time for an about-face? Lancet Diabetes Endocrinol. 2017 Apr;5(4):246-248. doi: 10.1016/S2213-8587(16)30276-5. Epub 2016 Oct 28. PMID: 28029536.

Mikulic M. Top chemical substances dispensed in England 2023, by item number. Health, Pharma & Medtech› Pharmaceutical Products & Market. 2024 Jun 11.

Allport J, McCahon D, Hobbs FR, Roberts LM. Why are GPs treating subclinical hypothyroidism? Case note review and GP survey. Prim Health Care Res Dev. 2013;14(2):175-84. doi: 10.1017/S1463423612000230.

Published

30-11-2025
Statistics
Abstract Display: 301
PDF Downloads: 179
Dimension Badge

How to Cite

“Exploring Quality of Life Among Thyroid Patients in South Indian Communities: A Comprehensive Study”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 17, no. 6, Nov. 2025, pp. 495-02, https://doi.org/10.25004/IJPSDR.2025.170602.

Issue

Section

Research Article

How to Cite

“Exploring Quality of Life Among Thyroid Patients in South Indian Communities: A Comprehensive Study”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 17, no. 6, Nov. 2025, pp. 495-02, https://doi.org/10.25004/IJPSDR.2025.170602.

Most read articles by the same author(s)