Assessment of Targeted Millet Therapy for Oral Aphthous

Authors

  • Sireesha Kalva Osmania University

Abstract

Recurrent aphthous stomatitis (RAS), commonly called "canker sores," is a perplexing oral condition characterized by the recurrent development of painful aphthous ulcers on non-keratinized oral mucous membranes. This condition poses a significant challenge to patients and healthcare professionals due to its uncertain etiology. The study aims to evaluate the efficacy of millets in the management oral ulcers (aphthous). Millets are formulated in the form of an oral gel as gels are low cost and easily administered. Three types of millets are used for the study- Pearl millet, Foxtail millet and Finger millet. Millets are evaluated for anti-microbial and anti-inflammatory activity due to their rich content of essential vitamins, minerals, and antioxidants.  The anti-microbial activity of the millets and the standard drug, Amoxicillin were observed and the zone of inhibition was calculated at 100, 300 and 500 mg/ml concentrations. The anti-inflammatory activity was assessed by calculating the % inhibition of protein denaturation using the absorbance value. Millets showed significant activities when compared with the standard drug. All these properties of millets and the chemical constituents heal mouth ulcers providing efficient drug delivery. Thus, these millets can be incorporated in the form of gel for the treatment of mouth ulcer. 

Keywords:

Mouth ulcers , Millets, Anti microbial activity, gels

DOI

https://doi.org/10.25004/

References

Vorvick LJ, Zieve D. Mouth ulcers on MedlinePlus. ADAM. Inc. Retrieved 27 December 2012.

Shivaji SAK, Vaibhav RV. Formulation and development of quercetin and monoammonium glycyrrhizinate loaded gel for the treatment of mouth ulcer disease. Int J Pharm Sci Res. 2021; 12: 1789-98. Available from: doi: 10.13040/IJPSR.0975-8232.12(3).1789-98

Vaillant L, Samimi M. Aphthous ulcers and oral ulcerations. Presse Med. 2016; 45(2): 215–26. Available from: https://doi.org/10.1016/j.lpm.2016.01.005

Paleri V, Staines K, Sloan P, Douglas A, Wilson J. Evaluation of oral ulceration in primary care. Brit Med J. 2010; 340:2639. Available from: https://doi.org/10.1136/bmj.c2639

Kaur S, Chhabra M. Recent advancement in mouth ulcers treatment. Int J Pharm Biol Sci. 2020;14.

Minhas S, Sajjad A, Kashif M, Taj F, Al Waddani H, Khurshid Z. Oral ulcers presentation in systemic diseases: An update. Maced J Med Sci. 2019; 7(19): 3341. Available from: doi: 10.3889/oamjms.2019.689

Scully C, Porter S. Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral Maxillofac Surg. 2008; 46(3):198–206. Available from: https://doi.org/10.1016/j.bjoms.2007.07.201

Savage NW, Seymour GJ, Kruger BJ. Expression of class I and class II major histocompatibility complex antigens on epithelial cells in recurrent aphthous stomatitis. J Oral Pathol. 1986; 15(4):1915. Available from: https://doi.org/10.1111/j.1600-0714.1986.tb00605.x

Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Wu YC, Sun A. Recurrent aphthous stomatitis - Etiology, serum autoantibodies, anemia, hematinic deficiencies, and management. J Formos Med Assoc. 2019; 118(9):1279-1289. Available from: https://doi.org/10.1016/j.jfma.2018.10.023

Porter SR, Scully CC. Aphthous ulcers (recurrent). BMJ Clin Evid. 2007.

Katzung BG, Masters SB, Trevor AG. Basic and clinical pharmacology London: McGraw-Hill Education, 2012.

Shaikh S, Shete, Doijad R. Formulation and Evaluation Pharmaceutical aqueous gel of powdered Guava Leaves for Mouth Ulcer Treatment. Pharma Tutor. 2018; 6(4): 32 38. Available from: http://dx.doi.org/10.29161/PT.v6.i4.2018.32

Liang S, Liang K. Millet grain as a candidate antioxidant food resource: a review, International Journal of Food Properties. 2019; 22:1: 1652-166. Available from: http://dx.doi.org/10.1080/10942912.2019.1668406

Ian S Hornsey. Alcohol and its Role in the Evolution of Human Society chapter 4, Royal Society of Chemistry, pp. 254–256.

Published

30-01-2025
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How to Cite

“Assessment of Targeted Millet Therapy for Oral Aphthous”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 17, no. 1, Jan. 2025, https://doi.org/10.25004/.

Issue

Section

Research Article

How to Cite

“Assessment of Targeted Millet Therapy for Oral Aphthous”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 17, no. 1, Jan. 2025, https://doi.org/10.25004/.

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