Preclinical evaluation of herbal formulation against Progesterone induced obesity in mice
Abstract
The present study evaluated that anti-obesity potential of a formulation. As obesity is chronic metabolic condition and leads to various co-morbidities hence there is need to find out herbal promising treatment with maximum potential and minimum side effects. Marketed allopathic drugs have side effects hence here is switch to herbal treatment. Obesity was triggered via subcutaneous administration of progesterone over a 28-day period, during which both a polyherbal formulation and a standard treatment were given. Essential physical measurements were documented, along with serum parameters such as total cholesterol, triglycerides, LDL, HDL, and VLDL. Moreover, liver function enzymes (SGPT and SGOT) and glucose levels were evaluated, and a histopathological analysis of adipose tissue was conducted. The results demonstrated that the polyherbal formulation significantly reduced obesity-related parameters such as VLDL, total cholesterol, HDL, triglycerides, LDL in treatment group. These findings suggest that the polyherbal formulation effectively counteracts progesterone-induced obesity.
Keywords:
progesterone,, formulation, lipid profile, obesityDOI
https://doi.org/10.25004/IJPSDR.2025.170302References
Safaei M, Sundararajan EA, Driss M, Boulila W, Shapi’i A. A systematic literature review on obesity: Understanding the causes & consequences of obesity and reviewing various machine learning approaches used to predict obesity. Computers in Biology and Medicine [Internet]. 2021 Sep;136(104754). Available from: https://www.sciencedirect.com/science/article/pii/S0010482521005485
Panuganti KK, Kshirsagar RK, Nguyen M. Obesity [Internet]. Nih.gov. StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459357/
WHO. Obesity [Internet]. Who.int. World Health Organization: WHO; 2021. Available from: https://www.who.int/news-room/facts-in-pictures/detail/6-facts-on-obesity
World Health Organization. Obesity [Internet]. www.who.int. 2024. Available from: https://www.who.int/health-topics/noncommunicable-diseases/obesity#tab=tab_1
Sarma S, Sockalingam S, Dash S. Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications. Diabetes, Obesity and Metabolism [Internet]. 2021 Feb 23;23(S1):3–16. Available from: https://dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.14290
Paoli A, Tinsley G, Bianco A, Moro T. The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting. Nutrients [Internet]. 2019 Mar 28;11(4):719. Available from: https://www.ncbi.nlm.nih.gov/pubmed/30925707
Wong MC, Huang J, Wang J, Chan PS, Lok V, Chen X, Leung C, Wang HH, Lao XQ, Zheng ZJ. Global, regional and time-trend prevalence of central obesity: a systematic review and meta-analysis of 13.2 million subjects. European journal of epidemiology. 2020; 35:673-83. https://doi.org/10.1007/s10654-020-00650-3
Elagizi A, Kachur S, Carbone S, Lavie CJ, Blair SN. A review of obesity, physical activity, and cardiovascular disease. Current obesity reports. 2020; 9:571-81. https://doi.org/10.1007/s13679-020-00403-z
Salam RA, Padhani ZA, Das JK, Shaikh AY, Hoodbhoy Z, Jeelani SM, Lassi ZS, Bhutta ZA. Effects of lifestyle modification interventions to prevent and manage child and adolescent obesity: a systematic review and meta-analysis. Nutrients. 2020; 12(8):2208. https://doi.org/10.3390/nu12082208
Tak YJ, Lee SY. Anti-obesity drugs: long-term efficacy and safety: an updated review. The world journal of men's health. 2020; 39(2):208. https://doi.org/10.5534/wjmh.200010
Nagle AP, Prystowsky JB, Brintha Enestvedt, Pandolfino JE. Surgical Management of Obesity. CRC Press eBooks. 2024 May 28;609–19.
Ghanem OM, Pita A, Nazzal M, Johnson S, Diwan T, Obeid NR, et al. Obesity, organ failure, and transplantation: a review of the role of metabolic and bariatric surgery in transplant candidates and recipients. Surgical Endoscopy. 2024 Jul 1; 38(8):4138–51.
Test No. 423: Acute Oral toxicity - Acute Toxic Class Method. OECD Guidelines for the Testing of Chemicals, Section 4. OECD; 2002.
Abubakar A, Haque M. Preparation of medicinal plants: Basic extraction and fractionation procedures for experimental purposes. Journal of Pharmacy and Bioallied Sciences [Internet]. 2020 Jan 29; 12(1):1–10. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398001/
Ugusman A, Shahrin SAS, Azizan NH, Pillai SB, Krishnan K, Salamt N, et al. Role of Honey in Obesity Management: A Systematic Review. Frontiers in Nutrition [Internet]. 2022 Jun 24;9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263567/
Kumar P, Tripathi AK, Mishra J, Dash AK. Herbal And Polyherbal Formulation-An Approach Of Indian Traditional Medicinal System. NVEO-Natural Volatiles & Essential Oils Journal. 2021;6501-10.
Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure. OECD Guidelines for the Testing of Chemicals, Section 4. OECD; 2002.
Shirode D, Patil A, Kulkarni A, Chaudhari S, Sadar S, Tupe M. Effect of Polyherbal Formulation on High Fat Diet Induced Obesity in Rats. Uttar Pradesh Journal of Zoology. 2024 Aug 6; 45(16):454–63.
Yong W, Wang J, Leng Y, Li L, Wang H. Role of Obesity in Female Reproduction. International Journal of Medical Sciences. 2023; 20(3):366–75.
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