SYNTHESIS, CHARACTERIZATION AND ANTI-MICROBIAL EVALUATION OF SOME 2-IODO-N'-[(1E)-SUBSTITUTED PHENYLMETHYLIDENE] BENZOHYDRAZIDE ANALOGUES
Abstract
Reaction of 2-iodo benzohydrazide (1) with appropriately substituted aromatic aldehyde in glacial acetic acid yielded corresponding 2-Iodo-N'-[(1E)-Substituted Phenylmethylidene] Benzohydrazides (2). Structures of all the compounds (2) were established on the basis of elemental analysis and spectral data. These compounds were screened for anti-bacterial and anti-fungal activities at 200µg/0.1ml (T1) and 400µg/0.1ml (T2). Results obtained illustrates that the compounds F, C, D and G showed highly significant response while compound H showed less significant response for anti-microbial activity at both concentrations 200µg/0.1ml (T1) and 400µg/0.1ml (T2).
Keywords:
Phenylmethylidene benzohydrazides, glacial acetic acid, anti-bacterial, anti-microbialDOI
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Copyright (c) 2010 Sunil L. Harer, Vikas G. Rajurkar, Pravin Patil, Priyanka S. Harer, Sampat D. Navale, Sandip T. Awuti, Anand A. Sonawane
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