SELECTIVE CYTOTOXIC ACTIVITY OF SYNTHETIC NATURAL CYCLOPEPTIDES ON HCT11 & B16F10 CELLS

Abstract

Peptides are natural messenger molecules of human body and hence ideal lead compounds for the initiation of drug discovery research. They are the important organic compounds with potent biological activities. Peptides functions as hormones, enzymes enzyme inhibitors, or substrates or growth inhibitors or promoters, neurotransmitters and immunomodulators. Investigation of new and more potent analogs of molecules with already established activities from a key part of research in pharmaceutical field. It’s brings many modifications by manipulates the parent molecules structures serves to increase the activity of the compound, also eliminate adverse effect or toxicity associated with the parent drug. Cancer is the leading cause of deaths in world, We evaluated four natural cyclopeptides Diandrine A, Diandrine C, Fanlizhicyclopeptide A, Fanlizhicyclopeptide B, for cytotoxicity against HCT116 (Human Colorectal Carcinoma) & B16F10 (musculus skin melanoma) cells.