ANTIBACTERIAL, CYTOTOXIC AND ANTIOXIDANT POTENTIAL OF DIFFERENT EXTRACTS FROM LEAF, BARK AND WOOD OF TECTONA GRANDIS

Authors

  • Mahesh S. Krishna Department of Biotechnology, University of Kerala, Karyavattom, Kerala, India
  • Jayakumaran Nair A. Department of Biotechnology, University of Kerala, Karyavattom, Kerala, India

Abstract

The timber value of Tectona grandis has been well known from decades. Teak is a major exotic species found in tropical regions. The present study was meant to characterize pharmacological potential of different extracts from leaf, bark and wood of teak. Antibacterial activity of all extracts from Tectona grandis were checked against Staphylococcus aureus (ATCC 25923), Klebsiella pneumoniae (ATCC 700603), hospital strains of Salmonella paratyphi and Proteus mirabilis by disc diffusion assay. Chloroform extract of leaf showed inhibition to growth of S. aureus (14 mm) and K. pneumoniae (8 mm). Cytotoxic potential of extracts were checked by MTT assay and chloroform extract of bark exhibited very high activity against chick embryo fibroblast (CEF) and human embryonic kidney (HEK 293) cells with 87 % and 95.3 % inhibition respectively. Antioxidant activity of extracts was checked with DPPH and ABTS+ free radical. Ethyl acetate extract of wood showed very high activity with 98.6 % inhibition against DPPH and ABTS+ free radicals. The value was higher than standard compounds used for the study.

Keywords:

Tectona grandis, antibacterial, cytotoxicity, antioxidant, disc diffusion assay, MTT assay, DPPH, free radical scavenging

DOI

https://doi.org/10.25004/IJPSDR.2010.020215

Published

01-04-2010
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How to Cite

“ANTIBACTERIAL, CYTOTOXIC AND ANTIOXIDANT POTENTIAL OF DIFFERENT EXTRACTS FROM LEAF, BARK AND WOOD OF TECTONA GRANDIS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 2, Apr. 2010, pp. 155-8, https://doi.org/10.25004/IJPSDR.2010.020215.

Issue

Section

Research Article

How to Cite

“ANTIBACTERIAL, CYTOTOXIC AND ANTIOXIDANT POTENTIAL OF DIFFERENT EXTRACTS FROM LEAF, BARK AND WOOD OF TECTONA GRANDIS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 2, Apr. 2010, pp. 155-8, https://doi.org/10.25004/IJPSDR.2010.020215.

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