ANTIBACTERIAL, CYTOTOXIC AND ANTIOXIDANT POTENTIAL OF DIFFERENT EXTRACTS FROM LEAF, BARK AND WOOD OF TECTONA GRANDIS
Abstract
The timber value of Tectona grandis has been well known from decades. Teak is a major exotic species found in tropical regions. The present study was meant to characterize pharmacological potential of different extracts from leaf, bark and wood of teak. Antibacterial activity of all extracts from Tectona grandis were checked against Staphylococcus aureus (ATCC 25923), Klebsiella pneumoniae (ATCC 700603), hospital strains of Salmonella paratyphi and Proteus mirabilis by disc diffusion assay. Chloroform extract of leaf showed inhibition to growth of S. aureus (14 mm) and K. pneumoniae (8 mm). Cytotoxic potential of extracts were checked by MTT assay and chloroform extract of bark exhibited very high activity against chick embryo fibroblast (CEF) and human embryonic kidney (HEK 293) cells with 87 % and 95.3 % inhibition respectively. Antioxidant activity of extracts was checked with DPPH and ABTS+ free radical. Ethyl acetate extract of wood showed very high activity with 98.6 % inhibition against DPPH and ABTS+ free radicals. The value was higher than standard compounds used for the study.
Keywords:
Tectona grandis, antibacterial, cytotoxicity, antioxidant, disc diffusion assay, MTT assay, DPPH, free radical scavengingDOI
https://doi.org/10.25004/IJPSDR.2010.020215Published


How to Cite
Issue
Section
Copyright (c) 2010 Mahesh S. Krishna, Jayakumaran Nair A.

This work is licensed under a Creative Commons Attribution 4.0 International License.