Exploring Modern Insights into Phytochemistry, Pharmacological, Toxicology, and Industrial Potential of Euphorbia tirucalli Linn
Abstract
Medicinal plant often referred as phytomedicine or botanical medicine or plant medicine. For thousands of years, traditional healthcare systems throughout the world have relied heavily on herbal medicines. In addition to reflecting the knowledge of past societies these natural cures nevertheless have an impact on contemporary medical procedures. Herbal therapy is now prized for its cost, accessibility and all-encompassing approach to health. The goal of this narrative review summarizes the available literature on the phytochemistry, pharmacological properties, toxicological profile, industrial potential and current information on the phytochemical compositions and therapeutic uses of different portions of Euphorbia tirucalli. This plant is known for a variety of medicinal applications E. tirucalli is the family of Euphorbiaceae which is also known as ‘pencil tree’ or ‘Barki Tohar’. Despite being native to Americas, the species has effectively adapted and is now widely distributed throughout India, where it is acknowledged as a commonly used medicinal herb. Both the milky latex and the stem bark are used in traditional methods. The latex has dose dependent effects in little amounts, it functions as a moderate purgative, but in greater doses, it becomes bitter, counter irritating and emetic. Pharmacological studies in-vitro and in-vivo have shown that the latex and bark exhibit a variety of biological activities, such as antimutagenic, antibacterial and antiherpetic qualities. It’s interesting to note that the latex has both cocarcinogenic and anticarcinogenic capabilities. Its ethnomedical significance across culture is further demonstrated by the traditional use of it as a folk treatment against syphilis in northeastern Brazil. The phytochemistry, taxonomical distribution, morphology, and other pharmacological characteristics of E. tirucalli are highlighted in this paper, which may encourage a thorough assessment of the plant as a therapeutic agent.
Keywords:
Euphorbia tirucalli, Phytochemistry, Pharmacological activities, Ethnomedicine, Traditional uses, Bioactive compoundsDOI
https://doi.org/10.25004/References
Gupta N, Vishnoi G, Wal A, Wal P. Medicinal value of Euphorbia tirucalli. Syst Rev Pharm. 2013 Jan 4(1):40. doi: 10.4103/0975-8453.111256.
Sonar P, Khasawad S, Walhe A, Tayde A. A review on pencil cactus (Euphorbia tirucalli). Int J Res Appl Sci Eng Technol. 2021 Jul 9(7), 607–620. doi:10.22214/ijraset.2021.60720.
Latif A, Lawati AM, Udas S, Chaudhary N, Chaudhary A, Limbu BR. Evaluation of antibacterial and antimycotic potency of Euphorbia tirucalli (L.) Int J Environ Monit Anal. 2025 Aug 13(4),122–134. doi: 10.11648/j.ijema.20251304.12.
Kayseri O, Dos Santos OJ, Sauaia Filho EN, Nascimento FRF, Silva Júnior FC, Fialho EMS, Santos RH, Santos RA. Use of raw Euphorbia tirucalli extract for inhibition of ascitic Ehrlich tumour. Rev Col Bras Cir. 2016 Feb 43(2),106–111. doi: 10.1590/0100-69912016002011.
Behery FA, Elmaidomy AH, Abd El Baky RM, Mawhoup MA, Bedaiwi RI, Abou Zied HA, Rateb ME, Abdelmohsen. Phytochemical profiling of Euphorbia tirucalli Linn. latex and evaluation of its in vitro antibacterial activity against resistant Klebsiell pneumoniae. RSC Adv. 2026 Mar 16(16), 11234–11250. doi: 10.1039/D6RA00720A.
Khan AQ, Kazmi SN, Ahmed Z, Malik A. Euphorcinol: a new pentacyclic triterpene from Euphorbia tirucalli. Planta Med. 1990 Jun 55(3), 290–291. doi: 10.1055/s-2006-962008.
Gupta SS, Mahadevan V. Isolation of euphol from Euphorbia tirucalli Linn. Indian J Exp Biol. 1967 Mar 5(3), 155–156. doi: 10.1016/S0031-9422(00)83044-2.
Yoshida T, Yokoyama K, Namba O, Okuda T. Tannins and related polyphenols of Euphorbiaceous plants. VII. Tirucallins A, B and euphorbin F, monomeric and dimeric ellagitannins from Euphorbia tirucalli L. Chem Pharm Bull (Tokyo). 1991 Apr 39(4), 1157–1162. doi: 10.1248/cpb.39.1157.
Baslas KK, Gupta SS. Phytochemical studies on Euphorbia tirucalli Linn. Indian J Exp Biol. 1982 Jun 20(6), 534–535. doi: 10.1016/S0031-9422(00)83044-2.
Khan AQ, Rasool N, Malik A. A taraxerane type triterpene from Euphorbia tirucalli. Phytochemistry. 1987 Apr 26(4), 1193–1195. doi: 10.1016/S0031-9422(00)97605-4.
Rasool N, Khan AQ, Malik A. A taraxerane type triterpene from Euphorbia tirucalli. Phytochemistry. 1989 Apr 28(4) 1193–1195. doi: 10.1016/S0031-9422(00)97605-4.
Chauhan JB, Singh V. Pharmacognostic and phytochemical studies on Euphorbia tirucalli Linn. J Chem Pharm Res. 2011 Dec 3(6), 1–6. doi: 10.1016/S0031-9422(00)97605-4.
Lekhya P, Rao BV, Rao RN, Rao DS. Pharmacognostic and phytochemical evaluation of Euphorbia tirucalli Linn. Int J Pharm Biol Sci. 2011 Sep 2(3) B321–B325. doi: 10.22376/ijpbs.2011.2.3.b321 b325.
Akhtar N, Khan RA, Malik A, Ahmad M, Saeed T, Ahmed S, et al. Phytochemical and pharmacological studies on Euphorbia tirucalli Linn. J Med Plants Res. 2013 Jul 7(27), 2001–2006. doi: 10.5897/JMPR12.1234.
Mali PY, Panchal SS. Euphorbia tirucalli L.: Review on morphology, medicinal uses, phytochemistry and pharmacological activities. Asian Pac J Trop Biomed. 2017 Jul 7(7):603–613. doi: 10.1016/j.apjtb.2017.06.013.
Nyigo VA, Mdegela RH, Mosha RD, Nonga HE, Karimuribo ED, Mtambo MMA, Antimicrobial activity of Euphorbia tirucalli extracts against selected pathogenic bacteria. J Med Plants Stud. 2016 Nov 4(6), 45–50. doi: 10.22271/plants.2016.v4.i6.07.
López Martínez LX, López Martínez LX, Juárez Flores BI, Zepeda Vallejo LG, García Cruz L, Espinosa Andrews H. Phytochemical constituents and antioxidant capacity of Euphorbia tirucalli extracts. Pharmacogn Mag. 2015 Oct 11(44), 403–409. doi: 10.4103/0973-1296.153094.
Behery EA, Behery M. Dynamic Pricing and Market Valuation: Evidence from the Egyptian Telecommunications Sector. World Research of Business Administration Journal. 2026 Mar 6(1) 23-35. doi: 10.56830/WRBA032026.
Benjamaa S, El Kharrassi Y, El Hachimi G, El Hachimi A, El Hachimi M. Phytochemical composition and biological activities of Euphorbia tirucalli Linn. extracts. J Ethnopharmacol. 2022 May 283, 114706. doi: 10.1016/j.jep.2021.114706.
Elmaidomy AH, Rodrigues ML, Gomes AJ, Funez MI, Marques MAS, Lunardi CN. Euphorbia tirucalli latex loaded polymer nanoparticles. PLoS One. 2022 Nov 17(11), e0274432. doi: 10.1371/journal.pone.0274432.
Bakhsh K. In vitro antifungal activity of polymeric nanoparticles loaded with methanolic extract of Euphorbia tirucalli. Preprint (Research Square). 2023 Mar 11(44), 403–409 doi: 10.21203/rs.3.rs-2739056/v1.
Pivec T, Pham T, Nguyen DH, et al. Chemical constituents of Euphorbia tirucalli L. Sci Tech Dev J – Nat Sci. 2019 Oct 2(5), 781–788. doi:10.32508/STDJNS.V2I5.781.
Doris J, Abhi S. Toxicity of aqueous extract of Euphorbia tirucalli latex on catfish (Heteropneustes fossilis). Ecotoxicol Environ Saf. 2010 Oct 73(7), 1671–1673. doi: 10.1016/j.ecoenv.2010.04.004.
Ghodake SB, Lee DS, Kim DY. Physicochemical and phytochemical characterization of Euphorbia tirucalli latex and its cytotoxic activity. Ind Crops Prod. 2011 Aug 34(1), 1208–1215. doi: 10.1016/j.indcrop.2011.04.018.
Prabha MN, Ramesh CK, Kuppast IJ, Mankani KL. Studies on anti inflammatory and analgesic activities of Euphorbia tirucalli L. latex. Int J Chem Sci. 2008 Dec 6(4) 1781–1787. doi: 10.9735/0972 768X.
Priya Rao S, Swathi PM, Unnikrishnan B, Hegde A. Study of complementary feeding practices among mothers of children aged six months to two years: a study from coastal south India. Australas Med J. 2011 May 4(5), 252 257. doi: 10.4066/AMJ.2011.607.
Bezerra JMT, Silva JS, Ibiapina SS, Tadei WP, Pinheiro VCS. Evaluation of students' knowledge as a contribution to dengue control programs. Cien Saude Colet. 2011 Nov 16(11), 4367 4373. doi: 10.1590/S1413-81232011001200009.
Jurberg P, Cabral Neto JB, Schall VT. Molluscicide activity of the “Avelós” plant (Euphorbia tirucalli L.) on Biomphalaria glabrata, the mollusc vector of schistosomiasis. Mem Inst Oswaldo Cruz. 1985 Oct 80(4),423 427. doi: 10.1590/S0074-02761985000400007.
Valadares MC, Carrucha SG, Accorsi W, Queiroz ML. Euphorbia tirucalli L. modulates myelopoiesis and enhances resistance of tumour bearing mice. Int Immunopharmacol. 2006 Feb 6(2), 294 299. doi: 10.1016/j.intimp.2005.08.014.
Dutra RC, Silva KABS da, Bento AF, Marcon R de O, Paszcuk AF, Meotti FC, Pianowski LF, Calixto JB. Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system. Neuropharmacology. 2012 Sep 63(4), 593 605. doi: 10.1016/j.neuropharm.2012.05.008.
Jurberg P, Cabral Neto JB, Schall VT. Molluscicide activity of the “Avelós” plant (Euphorbia tirucalli L.) on Biomphalaria glabrata, the mollusc vector of schistosomiasis. Mem Inst Oswaldo Cruz. 1985 Oct 80(4), 423 427. doi: 10.1590/S0074-02761985000400007.
Juliana FR, Oliveira RJ, Silva AF, Matos MFC, Matos MLC, Matos M. Evaluation of mutagenic and genotoxic effects of Euphorbia tirucalli latex and phytotherapeutic solutions using Inductest, Ames test, and Chromotest. Genet Mol Biol. 2011 Dec 34(4), 689 693. doi: 10.1590/S1415 47572011005000057.
De Araújo KM, De Lima A, Silva JD, Rodrigues LL, Amorim AG, Quelemes PV, Dos Santos RC, Rocha JA, De Andrades ÉO, Leite JR, Mancini-Filho J. Identification of phenolic compounds and evaluation of antioxidant and antimicrobial properties of Euphorbia tirucalli L. Antioxidants. 2014 Mar 3(1), 159-75. doi: 10.3390/antiox3010159.
Palharini JG, Richter AC, Silva MF, Ferreira FB, Pirovani CP, Naves KS, Goulart VA, Mineo TW, Silva MJ, Santiago FM. Eutirucallin: a lectin with antitumor and antimicrobial properties. Frontiers in Cellular and Infection Microbiology. 2017 Apr 25 (7),136. doi: 10.3389/fcimb.2017.00136.
Munro B, Vuong QV, Chalmers AC, Goldsmith CD, Bowyer MC, Scarlett CJ. Phytochemical, antioxidant and anti-cancer properties of Euphorbia tirucalli methanolic and aqueous extracts. Antioxidants. 2015 Oct 8 4(4), 647-61. doi: 10.3390/antiox4040647.
Abdel-Aty AM, Hamed MB, Salama WH, Ali MM, Fahmy AS, Mohamed SA. Ficus carica, Ficus sycomorus and Euphorbia tirucalli latex extracts: Phytochemical screening, antioxidant and cytotoxic properties. Biocat and Agri Biotech. 2019 Jul 1;20, 101199. doi: 10.1016/j.bcab.2019.101199.
Betancur Galvis LA, Morales GE, Forero JE, Roldan J. Cytotoxic and antiviral activities of Colombian medicinal plant extracts of the Euphorbia genus. Mem Inst Oswaldo Cruz. 2002 Jun 97(4), 541 546. doi: 10.1590/S0074 02762002000400017.
Cesar PY, Shital SP. Euphorbia tirucalli L.: Review on morphology, medicinal uses, phytochemistry and pharmacological activities. Asian Pac J Trop Biomed. 2017 Jul 7(7), 603 613. doi: 10.1016/j.apjtb.2017.06.002.
Varricchio MCBN, Pereira C, Sales F, Gomes T, Daudt E, Aquino CL, Barbosa GM, Gomes N, Pyrrho AS, Hobaica PEM, Castelo Branco M, Kuster R, Holandino C. Chronic toxicological effects of high diluted solutions of Aveloz (Euphorbia tirucalli L.) on healthy mice: a preliminary study. Int J High Dilution Res. 2008 Dec 7(25), 174 178.
Fürstenberger G, Hecker E. New highly irritant euphorbia factors from latex of Euphorbia tirucalli L. Experientia. 1977 Aug 33(8), 986–988. doi: 10.1007/BF01945920.
Franco Salla GB, Prates J, Cardin LT, Dos Santos ARD, Silva WA Jr, da Cunha BR, Tajara EH, Oliani SM, Rodrigues Lisoni FC. Euphorbia tirucalli modulates gene expression in larynx squamous cell carcinoma. BMC Complement Altern Med. 2016 16, 331. doi: 10.1186/s12906 016 1292 7.
Forster, J., Vaughan, N. E., Gough, C., Lorenzoni, I., & Chilvers, J. (2020). Mapping feasibilities of greenhouse gas removal: Key issues, gaps and opening up assessments. Glob Envirol Chan, 63, 102073. doi: org/10.1016/j.gloenvcha.2020.102073.
Bharucha NE, Bharucha EP, Bhabha SK. Machado-Joseph-Azorean disease in India. Arch Neurol. 1986 43(2) 142 144. doi: 10.1001/archneur.1986.00520020036014.
Tiwari GN, Singh HN, Tripathi R. Present status of solar distillation. Solar Energy. 2003 Nov 75(5) 367 373. doi: 10.1016/j.solener.2003.07.005.
Buckley MT, Sun ED, George BM, Liu L, Schaum N, Xu L, Reyes JM, Goodell MA, Weissman IL, Wyss-Coray T, Rando TA, Brunet A. Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain. Nat Aging. 2023 Jan 3(1), 121 137. doi: 10.1038/s43587-022-00335-4.
Cardial GM, Maciel LT, Almeida TF, Cardoso TC, Carvalho AB. Os efeitos farmacológicos e tóxicos da planta medicinal Euphorbia tirucalli: uma revisão sistemática. Cuadernos de Educación y Desarrollo. 2023 Nov 15(11), 14146 14166. doi: 10.55905/cuadv15n11-065
Hastilestari CS, Mudersbach M, Neubauer P, et al. Euphorbia tirucalli L. Comprehensive characterization of a drought tolerant plant with a potential as biofuel source. PLoS One. 2013 8(5), e63501. doi: 10.1371/journal.pone.006350.
Hussein G, Miyashiro H, Nakamura N, Hattori M, Kakiuchi N, Shimotohno K. Inhibitory effects of Sudanese medicinal plant extracts on hepatitis C virus protease. Phytother Res. 2000 14(7), 510 516. doi: 10.1002/1099-1573(200011)14:7.
Dutta J, Nath AK, Uddin MZ, Hossain MA, Morshed MM, Hassan K. In vitro antioxidant, total phenolic content and brine shrimp lethality studies of Synedrella nodiflora. Int J Pharm Sci Res. 2012 3(5), 1528 1531. doi: 10.13040/IJPSR.0975-8232.3(5).1528-31.
Upadhyay B, Pal S, Kumar A. Ethno medicinal, phytochemical and antimicrobial studies of Euphorbia tirucalli L. J Phytol. 2010 Mar 2(3) 65 77. doi: 10.3126/jps.v2i3.2176.
Monteiro Cardial G, Maciel LT, Almeida TF, Cardoso TC, Carvalho AB. Os efeitos farmacológicos e tóxicos da planta medicinal Euphorbia tirucalli: uma revisão sistemática. Cuadernos de Educación y Desarrollo. 2023 15(11) 14146 14166. doi:10.55905/cuadv15n11 065
Bacar A, Abdoul Latif F, Ali A, et al. Comparative metabolomic profiling and in vitro metabolic enzyme inhibitory activities of Euphorbia tirucalli from Nigeria and the Comoros Islands. J Ethnopharmacol. 2026 Aug 19(10), 23- 32. doi: 10.1016/j.jep.2026.102332.
Kumar A, Narayana AC, Jayappa KS. Shoreline changes and morphology of spits along southern Karnataka, west coast of India: a remote sensing and statistics-based approach. Geomorphology. 2010 120(1–2), 133 52. doi: 10.1016/j.geomorph.2010.02.023
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