PHYTO-PHARMACOLOGY OF CELASTRUS PANICULATUS: AN OVERVIEW
Abstract
Celastrus paniculatus (CP), a traditional Ayurvedic medicinal plant used for centuries as a memory enhancing, anti-inflammatory, analgesic, sedative and antiepileptic agent. The seed extract has been extensively investigated in several laboratories for their neuropharmacological effects and a number of reports are available confirming their nootropic action. In addition, researchers have evaluated the anti-inflammatory, anticonvulsant and other pharmacological effects of CP preparations/extracts. Therefore, in view of the important activities performed by this plant, investigation must be continued in the recently observed actions described in this paper. Moreover, clinical studies have to be encouraged, also to evidence any side effects and possible interactions between this herbal medicine and synthetic drugs.
Keywords:
paniculatus, Ayurvedic, Medicinal plant, Nootropic actionDOI
https://doi.org/10.25004/IJPSDR.2010.020303References
1. Nadkarni AK. Indian Materia Medica. Edn 3, Vol. I, Popular Prakashan, Bombay, 1976, pp. 296.
2. Vaidyaratnam PSV. Indian Medicinal Plants: A Compendium of 500 species. Edn 1, Vol. II, Orient Longman Ltd, Madras, 1997, pp. 47.
3. Sastry JLN, Chunekar KC. Dravyaguna Vijnana. Edn 3, Vol. II, Choukhamba, Orientalia, Varanasi, 2008, pp.128-131.
4. Kumaraswamy ON, Manjunath BL. Chemical examination of the fixed oil from the seeds of Celastrus paniculatus Willd. Journal of Indian Chemical Society. 1936; 13: 353-357.
5. Warsi SA. The chemical examination of Celastrus paniculatus. Current Science. 1940; 9: 134-135.
6. Den Hertog Jr, Kruk C, Nanavati DD, Sukh Dev. Stereochemistry of malkanguniol and stereostructures of some other related polyalcohols from Celastrus paniculatus Willd. Tetrahedron Letter. 1974; 26:2219-2222.
7. Nanavati DD. Paniculatadiol (a new triterpene diol) from Celastrus paniculatus Willd. (Celastraceae). Journal of Oil Technology Association of India.1977; 9: 1-4.
8. Sengupta A, Sengupta C, Majumder UK. Chemical investigations of Celastrus paniculatus seed oil: Fett Wissen Technology. 1987; 89: 119-123.
9. Borbone N, Borrelli F, Montesano D, Izzo AA, Marino SD, Capasso R, Zollo F. Identification of a new sesquiterpene polyol ester from Celastrus paniculatus. Planta Medica. 2007; 73(8): 792-794.
10. Bhargava PN. Chemical examination of the unsaponifiable matter of the fat from the fleshy arils of Celastrus paniculatus. Proceeding. Indian Acadamy Science 1946; 24(A): 506-509.
11. Mukherjee K, Ray LN. Screening of some Indian plant species. Quart Journal of Crude Drug Research. 1980; 18:77-82.
12. Dutta SK, Sharma BN, Sharma PV. Dulcitol from the flowers of Malkanguni (Celastrus paniculatus Willd.). Bull Med Ethnobot Res. 1981; 2: 114-115.
13. Joshi MC, Sabnis SD. A phytochemical study of South Gujarat forests plants with special reference to the medicinal and of ethnobotanical interest. Bull Med Ethnobot Res. 1989; 10: 61-82.
14. Jain MK. Chemical examination of Celastrus paniculatus Willd. Indian J Chem. 1963; 1: 500.
15. Gamlath CB, Gunatilaka AAL, Tezuka Y, Kikuchi T, Balasubramaniam S. Quinine-methide, phenolic and related triterpenoids of plants of Celastraceae: further evidence for the structure of Celastranhydride. Phytochemistry.1990; 29(10): 3189-3192.
16. Wagner H, Heckel E. Struktur und stereochemie eines sesquiterpenesters und dreier sesquiterpen-alkaloide von Celastrus paniculatus Willd. Tetrahedron. 1975; 31(16): 1949-1956.
17. Saily A, Sahu R, Gupta B, Sondhi SM. Analysis for mineral elements of medicinal plants used for the treatment of asthma, syphilis, diarrhoea, skin diseases and rheumatism. Hamdard Med. 1994; 37(4): 18-22.
18. Atal CK, Srivastava JB, Wali BK, Chakravarty RB, Dhawan BN, Rastogi RP. Screening of Indian plants for biological activity: Part VIII. Indian J Exp Biol. 1978; 16: 330-349.
19. Patil KS, Suryavanshi J. Effect of Celastrus paniculatus Willd: Seed on adjuvant induced arthritis in rats. Phcog Mag. 2007; 3(11): 177-181.
20. Borbone N, Borrelli F, Montesano D, Izzo AA, Marino SD, Capasso R, Zollo F. Identification of a new sesquiterpene polyol ester from Celastrus paniculatus. Planta Med. 2007; 73: 792-794.
21. Kun Zhang, Yanhong Wang, Yaozu Chen, Yongqiang Tu, Hai Jing, Huang Humin, Huang Xiaofeng, Fan Jinsong. Sesquiterpenes from Celastrus paniculatus subsp. Paniculatus. Phytochemistry. 1998; 48(6): 1067-1069.
22. Yong Q Tu, Tong X Wu, Zi Zh Li, T Zhen, Yao Z Chen. Sesquiterpene polyol esters from Celastrus paniculatus. J Nat Prod. 1991; 54(5): 1383-1386.
23. Yong Q Tu, Yao Z Chen. Sesquiterpenoids from Celastrus paniculatus. J Nat Prod: 1993; 56(1): 122-125.
24. Gaitonde BB, Raiker KP, Shroff FN, Patel JR. Pharmacological studies with Malakanguni, an indigenous tranquillizing drug. Curr Med Prac. 1957; 1: 619-621.
25. Shroff FN, Gaitonde BB, Patel JR. Tranquillizers (An experimental study). J Group Hosp. 1959; 4: 160-173.
26. Sheth UK, Vaz A, Bellare RA, Deliwala CV. Behavioural and pharmacological studies of a tranqulising fraction from the oil of Celastrus paniculatus (Malkanguni oil). Arch Int Pharmacodyn Ther. 1963; 144: 34-50.
27. Jogleker G, Balwani TH. Review of tranquilizing effects of Celastrus paniculatus. J Ind Med Assoc. 1967; 1: 190-195.
28. Karanth KS, Haridas KK, Gunasundari S, Guruswami MN. Effect of Celastrus paniculatus on learning process. Arogya. 1980; 6: 137-139.
29. Karanth KS, Padma TK, Guruswami MN. Influence of Celastrus oil on learning and memory. Arogya J Health Sci. 1981; 7: 83-86.
30. Nalini K, Karanth KS, Rao A, Aroor AR. Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats. J Ethnopharm. 1995; 47(2): 101-108.
31. Gattu M, Boss KL, Terry Jr AV, Buccafusco JJ. Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus. Pharmacol Biochem Behav. 1997; 57: 793-799.
32. Kumar MHV, Gupta YK. Antioxidant property of Celastrus paniculatus willd: a possible mechanism in enhancing cognition. Phytomed. 2002; 9(4): 302-311.
33. Godkar P, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain. J Ethnopharm. 2004; 93: 213-219.
34. Jadhav RB, Patwardhan B. Anti-anxiety activity of Celastrus paniculatus seeds. Indian J Nat Prod. 2003; 19(3): 16-19.
35. Rajkumar R, Prem Kumar E, Sudha S, Suresh B. Evaluation of anxiolytic potential of Celastrus oil in rat models of behavior. Fitoterapia. 2007; 78: 120-124.
36. Somanadhan B, Varughese G, Palpu S, Sreedharan R, Gudiksen L, Smitt UW, Nyman U. An ethnopharmacological survey for potential angiotensin converting enzyme inhibitors from Indian medicinal plants. J Ethnopharmacol. 1999; 65: 103-112.
37. Wangoo D, Bidwai PP. Anti-spermatogenic effect of Celastrus paniculatus seed extract on the testis of albino rats. Fitoterapia. 1988; 59: 377-382.
38. Bidwai PP, Wangoo D, Sharma V. Effects of polar and semipolar compounds from the seeds of Celastrus paniculatus on the liver and kidneys in rats. Fitoterapia. 1990; 61(5): 417-424.
39. Ahmad F, Khan RA, Rasheed S. Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities. J Ethnopharm. 1994; 42(3): 193-198.
40. Parcha V, Gahlot M, Tomar Y, Ram V. Studies on physic-chemical properties, anti-inflammatory and antimicrobial activity of Celastrus paniculatus seed oil. Indian J Nat Prod. 2003; 19(2): 21-23.
41. Mathur NT, Varma M, Dixit VP. Hypolipidaemic and antiatherosclerotic effect of Celastrus paniculatus seed extract in cholesterol fed rabbits. Indian Drugs. 1993; 30: 76-82.
42. Russo A, Izzo AA, Cardile V, Borrelli F, Vanella A. Indian medicinal plants as antiradicals and DNA cleavage protectors. Phytomed. 2001; 8(2): 125-132.
43. Godkar P, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed water soluble extracts protect culture rat forebrain neuronal cells from hydrogen peroxide induced oxidative injury. Fitoterapia. 2003; 74(7-8): 658-669.
44. Godkar P, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells. Phytomed. 2006; 13: 29-36.
45. Harish BG, Krishna V, Santosh Kumar HS, Khadeer Ahamed BM, Sharath R, Kumara Swamy HM. Wound healing activity and docking of glycogen-synthase-kinase-3-beta-protein with isolated triterpenoid lupeol in rats. Phytomed. 2008; 15(9): 763-767.
46. Pavanandt K, Kyle Webster H, Yongvanitchit K, Kun-anake A, Dechatiwonse T, Nutakul W, Bansiddhi J. Schizontocidal activity of Celastrus paniculatus Willd. Against Plasmodium falciparum in vitro. Phytother Res. 1989; 3(4): 136-139.
47. Patel RP, Trivedi BM. The in vitro antibacterial activity of some medicinal oils. Indian J Med Res. 1962; 50: 218-222.
48. Pandya KK, Patel RB, Chakravarthy BK. Antibacterial activity of some Indian medicinal plants. Indian Drugs. 1990; 27: 415-4117.
49. Vonshak A, Barazani O, Sathiyamoorthy P, Shalev R, Vardy D, Golan-Goldhirsh A. Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens. Phytother Res. 2003; 17(9): 1123-1125.
2. Vaidyaratnam PSV. Indian Medicinal Plants: A Compendium of 500 species. Edn 1, Vol. II, Orient Longman Ltd, Madras, 1997, pp. 47.
3. Sastry JLN, Chunekar KC. Dravyaguna Vijnana. Edn 3, Vol. II, Choukhamba, Orientalia, Varanasi, 2008, pp.128-131.
4. Kumaraswamy ON, Manjunath BL. Chemical examination of the fixed oil from the seeds of Celastrus paniculatus Willd. Journal of Indian Chemical Society. 1936; 13: 353-357.
5. Warsi SA. The chemical examination of Celastrus paniculatus. Current Science. 1940; 9: 134-135.
6. Den Hertog Jr, Kruk C, Nanavati DD, Sukh Dev. Stereochemistry of malkanguniol and stereostructures of some other related polyalcohols from Celastrus paniculatus Willd. Tetrahedron Letter. 1974; 26:2219-2222.
7. Nanavati DD. Paniculatadiol (a new triterpene diol) from Celastrus paniculatus Willd. (Celastraceae). Journal of Oil Technology Association of India.1977; 9: 1-4.
8. Sengupta A, Sengupta C, Majumder UK. Chemical investigations of Celastrus paniculatus seed oil: Fett Wissen Technology. 1987; 89: 119-123.
9. Borbone N, Borrelli F, Montesano D, Izzo AA, Marino SD, Capasso R, Zollo F. Identification of a new sesquiterpene polyol ester from Celastrus paniculatus. Planta Medica. 2007; 73(8): 792-794.
10. Bhargava PN. Chemical examination of the unsaponifiable matter of the fat from the fleshy arils of Celastrus paniculatus. Proceeding. Indian Acadamy Science 1946; 24(A): 506-509.
11. Mukherjee K, Ray LN. Screening of some Indian plant species. Quart Journal of Crude Drug Research. 1980; 18:77-82.
12. Dutta SK, Sharma BN, Sharma PV. Dulcitol from the flowers of Malkanguni (Celastrus paniculatus Willd.). Bull Med Ethnobot Res. 1981; 2: 114-115.
13. Joshi MC, Sabnis SD. A phytochemical study of South Gujarat forests plants with special reference to the medicinal and of ethnobotanical interest. Bull Med Ethnobot Res. 1989; 10: 61-82.
14. Jain MK. Chemical examination of Celastrus paniculatus Willd. Indian J Chem. 1963; 1: 500.
15. Gamlath CB, Gunatilaka AAL, Tezuka Y, Kikuchi T, Balasubramaniam S. Quinine-methide, phenolic and related triterpenoids of plants of Celastraceae: further evidence for the structure of Celastranhydride. Phytochemistry.1990; 29(10): 3189-3192.
16. Wagner H, Heckel E. Struktur und stereochemie eines sesquiterpenesters und dreier sesquiterpen-alkaloide von Celastrus paniculatus Willd. Tetrahedron. 1975; 31(16): 1949-1956.
17. Saily A, Sahu R, Gupta B, Sondhi SM. Analysis for mineral elements of medicinal plants used for the treatment of asthma, syphilis, diarrhoea, skin diseases and rheumatism. Hamdard Med. 1994; 37(4): 18-22.
18. Atal CK, Srivastava JB, Wali BK, Chakravarty RB, Dhawan BN, Rastogi RP. Screening of Indian plants for biological activity: Part VIII. Indian J Exp Biol. 1978; 16: 330-349.
19. Patil KS, Suryavanshi J. Effect of Celastrus paniculatus Willd: Seed on adjuvant induced arthritis in rats. Phcog Mag. 2007; 3(11): 177-181.
20. Borbone N, Borrelli F, Montesano D, Izzo AA, Marino SD, Capasso R, Zollo F. Identification of a new sesquiterpene polyol ester from Celastrus paniculatus. Planta Med. 2007; 73: 792-794.
21. Kun Zhang, Yanhong Wang, Yaozu Chen, Yongqiang Tu, Hai Jing, Huang Humin, Huang Xiaofeng, Fan Jinsong. Sesquiterpenes from Celastrus paniculatus subsp. Paniculatus. Phytochemistry. 1998; 48(6): 1067-1069.
22. Yong Q Tu, Tong X Wu, Zi Zh Li, T Zhen, Yao Z Chen. Sesquiterpene polyol esters from Celastrus paniculatus. J Nat Prod. 1991; 54(5): 1383-1386.
23. Yong Q Tu, Yao Z Chen. Sesquiterpenoids from Celastrus paniculatus. J Nat Prod: 1993; 56(1): 122-125.
24. Gaitonde BB, Raiker KP, Shroff FN, Patel JR. Pharmacological studies with Malakanguni, an indigenous tranquillizing drug. Curr Med Prac. 1957; 1: 619-621.
25. Shroff FN, Gaitonde BB, Patel JR. Tranquillizers (An experimental study). J Group Hosp. 1959; 4: 160-173.
26. Sheth UK, Vaz A, Bellare RA, Deliwala CV. Behavioural and pharmacological studies of a tranqulising fraction from the oil of Celastrus paniculatus (Malkanguni oil). Arch Int Pharmacodyn Ther. 1963; 144: 34-50.
27. Jogleker G, Balwani TH. Review of tranquilizing effects of Celastrus paniculatus. J Ind Med Assoc. 1967; 1: 190-195.
28. Karanth KS, Haridas KK, Gunasundari S, Guruswami MN. Effect of Celastrus paniculatus on learning process. Arogya. 1980; 6: 137-139.
29. Karanth KS, Padma TK, Guruswami MN. Influence of Celastrus oil on learning and memory. Arogya J Health Sci. 1981; 7: 83-86.
30. Nalini K, Karanth KS, Rao A, Aroor AR. Effects of Celastrus paniculatus on passive avoidance performance and biogenic amine turnover in albino rats. J Ethnopharm. 1995; 47(2): 101-108.
31. Gattu M, Boss KL, Terry Jr AV, Buccafusco JJ. Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus. Pharmacol Biochem Behav. 1997; 57: 793-799.
32. Kumar MHV, Gupta YK. Antioxidant property of Celastrus paniculatus willd: a possible mechanism in enhancing cognition. Phytomed. 2002; 9(4): 302-311.
33. Godkar P, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed water soluble extracts protect against glutamate toxicity in neuronal cultures from rat forebrain. J Ethnopharm. 2004; 93: 213-219.
34. Jadhav RB, Patwardhan B. Anti-anxiety activity of Celastrus paniculatus seeds. Indian J Nat Prod. 2003; 19(3): 16-19.
35. Rajkumar R, Prem Kumar E, Sudha S, Suresh B. Evaluation of anxiolytic potential of Celastrus oil in rat models of behavior. Fitoterapia. 2007; 78: 120-124.
36. Somanadhan B, Varughese G, Palpu S, Sreedharan R, Gudiksen L, Smitt UW, Nyman U. An ethnopharmacological survey for potential angiotensin converting enzyme inhibitors from Indian medicinal plants. J Ethnopharmacol. 1999; 65: 103-112.
37. Wangoo D, Bidwai PP. Anti-spermatogenic effect of Celastrus paniculatus seed extract on the testis of albino rats. Fitoterapia. 1988; 59: 377-382.
38. Bidwai PP, Wangoo D, Sharma V. Effects of polar and semipolar compounds from the seeds of Celastrus paniculatus on the liver and kidneys in rats. Fitoterapia. 1990; 61(5): 417-424.
39. Ahmad F, Khan RA, Rasheed S. Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities. J Ethnopharm. 1994; 42(3): 193-198.
40. Parcha V, Gahlot M, Tomar Y, Ram V. Studies on physic-chemical properties, anti-inflammatory and antimicrobial activity of Celastrus paniculatus seed oil. Indian J Nat Prod. 2003; 19(2): 21-23.
41. Mathur NT, Varma M, Dixit VP. Hypolipidaemic and antiatherosclerotic effect of Celastrus paniculatus seed extract in cholesterol fed rabbits. Indian Drugs. 1993; 30: 76-82.
42. Russo A, Izzo AA, Cardile V, Borrelli F, Vanella A. Indian medicinal plants as antiradicals and DNA cleavage protectors. Phytomed. 2001; 8(2): 125-132.
43. Godkar P, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed water soluble extracts protect culture rat forebrain neuronal cells from hydrogen peroxide induced oxidative injury. Fitoterapia. 2003; 74(7-8): 658-669.
44. Godkar P, Gordon RK, Ravindran A, Doctor BP. Celastrus paniculatus seed oil and organic extracts attenuate hydrogen peroxide- and glutamate-induced injury in embryonic rat forebrain neuronal cells. Phytomed. 2006; 13: 29-36.
45. Harish BG, Krishna V, Santosh Kumar HS, Khadeer Ahamed BM, Sharath R, Kumara Swamy HM. Wound healing activity and docking of glycogen-synthase-kinase-3-beta-protein with isolated triterpenoid lupeol in rats. Phytomed. 2008; 15(9): 763-767.
46. Pavanandt K, Kyle Webster H, Yongvanitchit K, Kun-anake A, Dechatiwonse T, Nutakul W, Bansiddhi J. Schizontocidal activity of Celastrus paniculatus Willd. Against Plasmodium falciparum in vitro. Phytother Res. 1989; 3(4): 136-139.
47. Patel RP, Trivedi BM. The in vitro antibacterial activity of some medicinal oils. Indian J Med Res. 1962; 50: 218-222.
48. Pandya KK, Patel RB, Chakravarthy BK. Antibacterial activity of some Indian medicinal plants. Indian Drugs. 1990; 27: 415-4117.
49. Vonshak A, Barazani O, Sathiyamoorthy P, Shalev R, Vardy D, Golan-Goldhirsh A. Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens. Phytother Res. 2003; 17(9): 1123-1125.
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01-07-2010
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“PHYTO-PHARMACOLOGY OF CELASTRUS PANICULATUS: AN OVERVIEW”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 3, July 2010, pp. 176-81, https://doi.org/10.25004/IJPSDR.2010.020303.
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“PHYTO-PHARMACOLOGY OF CELASTRUS PANICULATUS: AN OVERVIEW”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 3, July 2010, pp. 176-81, https://doi.org/10.25004/IJPSDR.2010.020303.
