DEVELOPMENT AND EVALUATION OF EPICHLOROHYDRIN CROSS-LINKED MUCOADHESIVE PATCHES OF TAMARIND SEED POLYSACCHARIDE FOR BUCCAL APPLICATION
Abstract
In this study, buccal patches of metronidazole were formulated by solvent casting method using tamarind seed polysaccharide (TSP). The patches were crosslinked with epichlorohydrin and different batches were prepared following 23 factorial design. The patches were evaluated with respect to their ex-vivo drug permeation characteristics, mucoadhesive strength, folding endurance, and buccal residence time. At lower level of cross linker and plasticizer, the drug permeation was the highest (72.72%). The drug release from the patches was dominated by a dissolution-controlled mechanism rather than diffusion. The folding endurance did not vary widely (201-254), however the mucoadhesive strength (6.1-36.5 g) and the residence time (~2-6 h) deviated widely depending upon the formulation variables. The FT-IR spectroscopy revealed no interaction between drug and polymer. Thus the TSP could be a promising vehicle for the fabrication of buccal patches.
Keywords:
Tamarind seed polysaccharide, propylene glycol, Buccal patches, Metronidazole, Folding endurance, Ex vivo permeationDOI
https://doi.org/10.25004/IJPSDR.2010.020306References
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14. Kulkarni D, Dwivedi AK, Sarin JPS, Singh S. Tamarind seed polyose: A potential polysaccharide for sustained release of verapamil hydrochloride as a model drug. Indian J Pharm Sci. 1997; 59:1-7.
15. Mishra MU, Khandare JN, Tamarind Seed Polysaccharides: Biodegradable Polymer for Colonic Drug Delivery. Second International Conference and Indo-Canadian Satellite Symposium on Pharmaceutical Science, Technology, Practice and Natural Products, Conference Chronicle, 2007, pp. 206.
16. Stuart HJ. Statistical design applied to product design. J Qual Technol. 1985; 17: 210-221.
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18. Wechsler J. FDA proposes flexible oversight for quality systems. Pharm Technol. 2008; 32:32-38.
19. Lewis GA, Mathieu D, Lui RPT. Pharmaceutical Experimental Design. Marcel Dekker Inc, New York, 1999, pp. 185-246.
20. Ko JA, Park HJ, Park YS, Hwang S-J, Park JB. Chitosan microparticle preparation for control drug release by response surface methodology. J Microencapsul. 2004; 20: 791-797.
21. Rao PS, Ghosh TP, Krishna S. Extraction and purification of tamarind seed polysaccharide. J Sci Ind Research. 1946; 4:705.
22. Lenaerts V, Dumoulin Y, Maateescu MA. Controlled release of theophylline from cross- linked amylose tablets. J Control Rel. 1991; 15:39-46.
23. Korsmeyer RW, Peppas NA. Controlled Release Delivery Systems. Marcel Dekker, New York, 1981, pp.77-90.
24. Ritger PL, Peppas NA. A simple equation for description of solute release II Fickian and anomalous from swellable devices. J Control Rel. 1987; 5: 37-42.
25. Peppas NA, Sahlin JJ. A simple equation for the description of sustained release. III Coupling of diffusionand relaxation. Int J Pharm. 1989; 57:169-172.
26. Khurana R, Ahuja A, Khar RK. Development and evaluation of mucoadhesive films of miconazole nitrate. Indian J Pharm Sci.2000; 62:449-453.
2. Harris D, Robinson JR. Drug delivery via the mucous-membranes of the oral cavity. J Pharm Sci.1992; 81:1-10.
3. Senel S, Hincal AA. Drug penetration enhancement via buccal route: possibilities and limitation. J Control Rel. 2001; 72:133-144.
4. Choi H, Jung J, Yong CS, Lee RC, Park JH, Kim C. Formulation and in vivo evaluation of omeprazole buccal adhesive tablet. J Control Rel. 2000; 68: 405-412.
5. Martina L, Wilsona CG, Kooshab F, Uchegbu IF. Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels. Euro J Pharm Biopharm. 2003; 55:35-45.
6. Aspinall GO. Gums and mucilages. Adv Carbohydr Chem Biochem. 1969; 24: 333-379.
7. Gidley MJ, Lillford PJ, Rowlands DW, Lang P, Dentini M, Crescenzi V. Structure and solution properties of tamarind-seed polysaccharide. Carbohydr Res. 1991; 214:299-314.
8. Glicksman M. Food hydrocolloids. Boca Raton, FL: CRC Press, 1986.
9. Rao PS, Srivastava HC. Indusrtial Gums. Edn 2, Academic Press, New York, 1973, pp. 369-411.
10. Nishinari K, Yamatoya K, Shirakawa M. Hand book of Hydrocolloids. CRC Press, Florida, 2000, pp .247-267.
11. Saettone MF, Burgalassi S, Giannaccini B, Boldrini E, Bianchini P, Luciani G. Ophthalmic solutions viscosified with tamarind seed polysaccharide. International patent application no. PCT/IT97/00026, 1997.
12. Sano M, Miyata E, Tamano S, Hagiwara A, Ito N, Shirai T. Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F mice. Food and Chem Toxicol. 1996; 34: 463-467.
13. Burgalassi S, Panichi L, Saettone MF, Jacobsen J, Rassing MR. Development and in vitro/ in vivo testing of mucoadhesive buccal patches releasing benzydamine and lidocaine. Int J Pharm. 1996; 133: 1-7.
14. Kulkarni D, Dwivedi AK, Sarin JPS, Singh S. Tamarind seed polyose: A potential polysaccharide for sustained release of verapamil hydrochloride as a model drug. Indian J Pharm Sci. 1997; 59:1-7.
15. Mishra MU, Khandare JN, Tamarind Seed Polysaccharides: Biodegradable Polymer for Colonic Drug Delivery. Second International Conference and Indo-Canadian Satellite Symposium on Pharmaceutical Science, Technology, Practice and Natural Products, Conference Chronicle, 2007, pp. 206.
16. Stuart HJ. Statistical design applied to product design. J Qual Technol. 1985; 17: 210-221.
17. Schwartz JB, O’connor RE, Schnaare RL. Modern Pharmaceutics. Edn 4, Marcel Dekker Inc, New York, 2007, pp. 607-627.
18. Wechsler J. FDA proposes flexible oversight for quality systems. Pharm Technol. 2008; 32:32-38.
19. Lewis GA, Mathieu D, Lui RPT. Pharmaceutical Experimental Design. Marcel Dekker Inc, New York, 1999, pp. 185-246.
20. Ko JA, Park HJ, Park YS, Hwang S-J, Park JB. Chitosan microparticle preparation for control drug release by response surface methodology. J Microencapsul. 2004; 20: 791-797.
21. Rao PS, Ghosh TP, Krishna S. Extraction and purification of tamarind seed polysaccharide. J Sci Ind Research. 1946; 4:705.
22. Lenaerts V, Dumoulin Y, Maateescu MA. Controlled release of theophylline from cross- linked amylose tablets. J Control Rel. 1991; 15:39-46.
23. Korsmeyer RW, Peppas NA. Controlled Release Delivery Systems. Marcel Dekker, New York, 1981, pp.77-90.
24. Ritger PL, Peppas NA. A simple equation for description of solute release II Fickian and anomalous from swellable devices. J Control Rel. 1987; 5: 37-42.
25. Peppas NA, Sahlin JJ. A simple equation for the description of sustained release. III Coupling of diffusionand relaxation. Int J Pharm. 1989; 57:169-172.
26. Khurana R, Ahuja A, Khar RK. Development and evaluation of mucoadhesive films of miconazole nitrate. Indian J Pharm Sci.2000; 62:449-453.
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01-07-2010
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“DEVELOPMENT AND EVALUATION OF EPICHLOROHYDRIN CROSS-LINKED MUCOADHESIVE PATCHES OF TAMARIND SEED POLYSACCHARIDE FOR BUCCAL APPLICATION”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 3, July 2010, pp. 193-8, https://doi.org/10.25004/IJPSDR.2010.020306.
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How to Cite
“DEVELOPMENT AND EVALUATION OF EPICHLOROHYDRIN CROSS-LINKED MUCOADHESIVE PATCHES OF TAMARIND SEED POLYSACCHARIDE FOR BUCCAL APPLICATION”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 3, July 2010, pp. 193-8, https://doi.org/10.25004/IJPSDR.2010.020306.
