NOVEL SPECTROPHOTOMETRIC ANALYSIS OF PIROXICAM TABLETS USING IBUPROFEN SODIUM AS HYDROTROPIC SOLUBILIZING AGENTS
Abstract
The term hydrotropy has been used to designate the increase in solubility in water of various substances due to the presence of large amount of additives. Concentrated aqueous hydrotropic solutions of sodium benzoate, urea, nicotinamide, sodium salicylate, sodium ascorbate and sodium glycinate have been observed to enhance the aqueous solubility of many poorly water-soluble drugs. In the present investigation hydrotropic solubilization technique has been employed to solubilize the poorly water-soluble NSAID, piroxicam. Determination of solubilities of the drug in 1.5 M ibuprofen sodium hydrotropic solution and distilled water was carried out at 28±1°C. There was more than 50-fold enhancement in aqueous solubility of piroxicam with 1.5 M ibuprofen sodium (as compared to aqueous solubility). Therefore, it was thought worthwhile to solubilize the poorly water-soluble piroxicam from fine powder of its tablets to carryout spectrophotometric analysis at 358 nm. Ibuprofen sodium does not show any absorbance above 300 nm. Beerۥs law was obeyed in the concentration range of 5-35 μg/ml. Tablets containing piroxicam have been analyzed successfully. Recovery studies and statistical data proved the accuracy, reproducibility and the precision of the proposed method. Based on the same principle a large number of drugs having λmax above 300 nm can be estimated by 1.5 M ibuprofen sodium (inexpensive hydrotropic agent). Thus, hydrotropic solutions can be used in place of organic solvents (which are pollutants, toxic and give error due to volatility).
Keywords:
Piroxicam, Spectrophotometry, Hydrotropy, Ibuprofen sodiumDOI
https://doi.org/10.25004/IJPSDR.2010.020309References
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