SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SULFONAMIDE SCHIFF’S BASES
Abstract
Substituted sulfonamides were reacted with different aromatic aldehydes to form Schiff’s bases. TLC ascertained the purity of synthesized compounds on silica gel G coated plates and visualized by using iodine vapour. The structures of synthesized compounds were confirmed by their IR, 1H NMR spectroscopic data. The derivatives were subjected to antimicrobial activity using different bacterial strains (Klebsiella pneumoniae, gram negative bacteria and Staphylococcus epidermidis, Bacillus subtilis as gram positive bacteria with respect to Ciprofloxacin as standard antibiotics.
Keywords:
substituted sulfonamide, Ciprofloxacin, Schiff’s bases, antimicrobial activityDOI
https://doi.org/10.25004/IJPSDR.2010.020311References
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13. Siddiqui N, Pandeya SN, Khan SA, James S, Rana A, Mahfuz A. Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain. Bioorganic & Medicinal Chemistry Letters. 2007; 17: 255–259.
14. Singh HP, Sharma CS, Gautam CP. Synthesis and Pharmacological Screening of Some Novel 2-Arylhydrazino And 2-Aryloxy-Pyrimido [2, 1-B]Benzothiazole Derivatives. American-Eurasian Journal of Scientific Research. 2009; 4(4):222-228.
2. Parekh J, Inamdhar P. Synthesis and antibacterial activity of some Schiff bases derived from 4-aminobenzoic acid. J. Serb. Chem. Soc. 2005; 70(10):1163–1167.
3. Singh UK, Pandeya SN, Singh A, Srivastava BK, Pandey M. Synthesis and antimicrobial activity of Schiff’s and n-Mannich bases of Isatin and its derivatives with 4-amino-n-carbamimidoyl benzene sulfonamide. International Journal of Pharmaceutical Sciences and Drug Research. 2010; 2(2): 151-154.
4. Panneerselvam P, Rather BA, Reddy DRS, Kumar NR. Synthesis and anti-microbial screening of some Schiff bases of 3-amino-6,8-dibromo-2-phenylquinazolin-4(3H)-ones. European Journal of Medicinal Chemistry. 2009; 44(5):2328-2333.
5. Singh UK, Pandeya SN, Jindal S, Pandey M, Srivastava BK, Singh A. Synthesis and Antimicrobial Activity of Schiff’s and Mannich Bases of 1H-Indole-2,3-Dione Derivatives. Der Pharma Chemica. 2010; 2(2): 392-399.
6. Manikpuri AD. Synthesis and antimicrobial studies on therapeutically significant Schiff bases of Salicaldehyde and Sulphonamides. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2010; 1(2):21-27.
7. Kumar S, Niranjan MS, Chaluvaraju KC, Jamakhandi CM, Kadadevar D. Synthesis and antimicrobial study of some Schiff Bases of Sulfonamides. Journal of Current Pharmaceutical Research. 2010; 01: 39-42.
8. Iqbal N, Iqbal J, Imran M. Synthesis, characterization and antibacterial screening of some metal complexes of a Schiff Base derived from Benzaldehyde and Sulphonamide. Journal of Scientific Research. 2009; 19(1):15-19.
9. Zarghi A, Zebardast T, Hakimion F, Shirazi FH, Rao PNP, Knaus EE. Synthesis and biological evaluation of 1, 3-diphenylprop-2-en-1-ones possessing a methanesulfonamido or an azido pharmacophore as cyclooxygenase-1/-2 inhibitors. Bioorganic & Medicinal Chemistry. 2006; 14(20):7044–7050.
10. Vazzana I, Terranova E, Mattioli F, Sparatore F. Aromatic Schiff bases and 2,3-disubstituted-1,3-thiazolidin-4-one derivatives as anti-inflammatory agents. ARKIVOC. 2004; V: 364-374.
11. George TG, Johnsamuel J, Delfín DA, Yakovich A, Mukherjee M, Phelps MA, Dalton JT, Sackett DL, Kaiser M, Brun R, Werbovetz KA. Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides. Bioorganic & Medicinal Chemistry. 2006; 14(16): 5699-5710.
12. Kamel MM, Ali HI, Anwar MM, Mohamed NA, Soliman AM. Synthesis, antitumor activity and molecular docking study of novel Sulfonamide-Schiff's bases, thiazolidinones, benzothiazinones and their C-nucleoside derivatives. European Journal of Medicinal Chemistry. 2010; 45(2):572-580.
13. Siddiqui N, Pandeya SN, Khan SA, James S, Rana A, Mahfuz A. Synthesis and anticonvulsant activity of sulfonamide derivatives-hydrophobic domain. Bioorganic & Medicinal Chemistry Letters. 2007; 17: 255–259.
14. Singh HP, Sharma CS, Gautam CP. Synthesis and Pharmacological Screening of Some Novel 2-Arylhydrazino And 2-Aryloxy-Pyrimido [2, 1-B]Benzothiazole Derivatives. American-Eurasian Journal of Scientific Research. 2009; 4(4):222-228.
Published
01-07-2010
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“SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SULFONAMIDE SCHIFF’S BASES”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 3, July 2010, pp. 216-8, https://doi.org/10.25004/IJPSDR.2010.020311.
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How to Cite
“SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME SULFONAMIDE SCHIFF’S BASES”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 3, July 2010, pp. 216-8, https://doi.org/10.25004/IJPSDR.2010.020311.
