SYNTHESIS, BIOLOGICAL EVALUATION AND ELECTROCHEMICAL STUDIES OF CU (II) AND NI (II) COMPLEXES OF N’, N”-1, 2-DIPHENYLETHANE-1, 2-DIYLIDENEDIBENZOHYDRAZIDE

Authors

  • Nasir Hussain Synthetic Organic Chemistry Laboratory
  • Pooja Joshi Coordination Chemistry Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur, Rajasthan 313 001, India
  • Rajaram Dangi Synthetic Organic Chemistry Laboratory
  • Rehana Khanam Coordination Chemistry Laboratory, Department of Chemistry, M. L. Sukhadia University, Udaipur, Rajasthan 313 001, India
  • Ganpat L. Talesaraa Synthetic Organic Chemistry Laboratory

Abstract

New tetra-dentate Schiff base N’, N”-1, 2-diphenylethane-1, 2-diylidenedibenzohydrazide (1) was synthesized by the condensation of benzil with isonizide. Further ligand (1) was converted into Cu (II) complex with N’, N”-1, 2-diphenylethane-1, 2-diylidenedibenzohydrazide (2) by treatment of (1) with CuCl2.2H2O and in another route Ni (II) complex with N’, N”-1, 2-diphenylethane-1, 2-diylidenedibenzohydrazide (3) was synthesized with reaction of (1) with NiSO4.7H2O. Polarographic studies of Cu (II) and Ni (II) complexes with ligand have been done in alcoholic medium and the stability constant log β values were found for Cu (II) and Ni (II) complexes Ligand and complexes were characterized by IR and 1HNMR, and complexes tested for biological activity.

Keywords:

Benzil, Schiff base, Polarograph and Stability constant

DOI

https://doi.org/10.25004/IJPSDR.2010.020409

References

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Published

01-10-2010
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“SYNTHESIS, BIOLOGICAL EVALUATION AND ELECTROCHEMICAL STUDIES OF CU (II) AND NI (II) COMPLEXES OF N’, N”-1, 2-DIPHENYLETHANE-1, 2-DIYLIDENEDIBENZOHYDRAZIDE”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 4, Oct. 2010, pp. 272-4, https://doi.org/10.25004/IJPSDR.2010.020409.

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Research Article

How to Cite

“SYNTHESIS, BIOLOGICAL EVALUATION AND ELECTROCHEMICAL STUDIES OF CU (II) AND NI (II) COMPLEXES OF N’, N”-1, 2-DIPHENYLETHANE-1, 2-DIYLIDENEDIBENZOHYDRAZIDE”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 4, Oct. 2010, pp. 272-4, https://doi.org/10.25004/IJPSDR.2010.020409.