KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATION OF TELITHROMYCIN IN BULK AND DRUG FORMULATION

Authors

  • F. M. Abou Attia National organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt
  • F. M. S. E. El-Dars Chemistry Department, Faculty of Science, Helwan University, Ain Helwan 11795, Helwan, Egypt
  • M. A. El-Ries National organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt
  • O. I. Mohamed Chemistry Department, Faculty of Science, Helwan University, Ain Helwan 11795, Helwan, Egypt
  • M. S. Mohamed College of Pharmacy, King Saud University, Riyadh

Abstract

A kinetic method for the accurate and sensitive determination of telithromycin has been described. The method is based on the oxidation of telithromycin with alkaline KMnO4. At a fixed time of 24 min. the formed magnate ion is spectrophotometrically measured at 610 nm. The concentration of telithromycin is calculated using the calibration equation for the fixed time and initial rate methods. Beer´s law was obeyed from 3.24-12.9µg ml-1 The assays limits of detection were 0.2-0.70µg ml-1 and the R.S.D. (n= 5) was 0.6 %. Recovery was 99.8 and 100.83%. The analytical performance of the, in terms of accuracy and precision, were statistically validated, the results were satisfactory RSD ≤ 2%. The method has been applied successfully to commercial tablet dosage form. Statistical comparison of the result with the reference method showed excellent agreement and proved that no significant difference in the accuracy and precision.

Keywords:

Telithromycin, Kinetics, Spectroscopic determination, KMnO4

DOI

https://doi.org/10.25004/IJPSDR.2010.020413

References

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Published

01-10-2010
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How to Cite

“KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATION OF TELITHROMYCIN IN BULK AND DRUG FORMULATION”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 4, Oct. 2010, pp. 286-90, https://doi.org/10.25004/IJPSDR.2010.020413.

Issue

Section

Research Article

How to Cite

“KINETIC SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATION OF TELITHROMYCIN IN BULK AND DRUG FORMULATION”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 2, no. 4, Oct. 2010, pp. 286-90, https://doi.org/10.25004/IJPSDR.2010.020413.