3D QSAR STUDY ON ALPHA KETO AMIDE DERIVATIVES AS GP120-CD4 INHIBITORS

Authors

  • Vinayak D. More Drug Development Sciences Research Group, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharastra, India
  • Prafulla B. Choudhari Drug Development Sciences Research Group, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharastra, India
  • Rakesh P. Dhavale Drug Development Sciences Research Group, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharastra, India
  • Swapnil D. Jadhav Drug Development Sciences Research Group, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharastra, India
  • Manish S. Bhatia Drug Development Sciences Research Group, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharastra, India

Abstract

The present communication deals with 3D QDAR analysis on series of Alpha keto amide derivatives some for the designing of new GP120-CD4 inhibitors with anti HIV activity. The four different QSAR models are generated using data set of 32 molecules as gp120-CD4 inhibitors from literature studies. The 3D QSAR result gives insights for understanding of the relationship between structural features of substituted alpha keto amide derivatives and their activities which should be useful to design newer potential anti-HIV agents.

Keywords:

Alpha keto amides, QSAR, MLR

DOI

https://doi.org/10.25004/IJPSDR.2012.040104

References

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Published

01-01-2012
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How to Cite

“3D QSAR STUDY ON ALPHA KETO AMIDE DERIVATIVES AS GP120-CD4 INHIBITORS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 1, Jan. 2012, pp. 19-24, https://doi.org/10.25004/IJPSDR.2012.040104.

Issue

Volume 4, Issue 1, 2012

Section

Research Article

How to Cite

“3D QSAR STUDY ON ALPHA KETO AMIDE DERIVATIVES AS GP120-CD4 INHIBITORS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 1, Jan. 2012, pp. 19-24, https://doi.org/10.25004/IJPSDR.2012.040104.