Application of Central Composite Design for Citalopram Hydrogen bromide Mouth Dissolving Films
Abstract
Citalopram is an antidepressant used for treating major depressive disorder. In the current work Citalopram HBr is formulated as mouth dissolving film with enhanced drug dissolution. The Central Composite Design (CCD), employed to examine the effects of amount of HPMC E50 (A), amount of maltodextrin (B) and amount of glycerol (C) on response variables tensile strength, disintegration time and cumulative % drug release. 27 formulations prepared according to CCD and evaluated for physicochemical parameters and in vitro dissolution studies. Citalopram HBr mouth dissolving films formulated by employing solvent-casting method using HPMC E50, maltodextrin and glycerol, optimized for the effective dosage of superdisintegrants. The formulation CF21 with maximum tensile strength of 67.21±1.31 gm, least disintegration time of 9±1.60 sec and highest drug release of 98.41±1.81% is chosen optimal formulation with maximum content uniformity and folding endurance. It is evident from the above results that the developed formulation can be an innovative dosage form to improve the drug delivery, quick onset of action as well as improve patient compliance in the effective management of depression.
Keywords:
Citalopram HBr, anti depressant, Central Composite Design (CCD), mouth dissolving films, solvent casting methodDOI
https://doi.org/10.25004/IJPSDR.2020.120408References
Seager HJ. Drug delivery products and zydis fast dissolving dosage forms. Pharm Pharmcol.1998; 50:375-382.
Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolve tablets of nimesulide using Vacuum drying technique. AAPS Pharm Sci Tech. 2004; 5:36
Carandang C, Jabbal R, Macbride A, Elbe D.A review of escitalopram and citalopram in child and adolescent depression. J Can Acad Child Adolesc Psychiatry. 2011; 20 (4): 315–24
Schwartz BJ,Connor RE. Optimization technique in pharmaceutical formulations and processing.J Drugs Pharm Sci Modern Pharm. 1996; 72:727-54.
Keshavarao KP, Dixit M. Formulation and Evaluation of Mouth Dissolving Film Containing Rofecoxib. IRJP. 2011; 2(3):273-278.
Montgomery, Douglas C. Design and Analysis of Experiments: Response surface method and designs, John Wiley and Sons, Inc. New Jersey, 2005, pp. 210-256.
Nair Rahul, Sevukarajan M, Vishnu Priya K, Arun Kumar K. Response Surface Methodology for the Optimization OF Ethyl cellulose Microspheres. Int J of Pharm Tech Res 2014; 3(2): 775-783.
Cilurzo F, Cupone IE, Minghetti P,Selmin, Montanari L. Fast dissolving films made of maltodextrins. Eur J Pharm Biopharm. 2008; 70 (3): 895–900.
Kulkarni AS, Deokule HA, Mane MS,Ghadge DM. Exploration of different polymers for use in the formulation of oral fast dissolving strips. J Current Pharm Res. 2010; 2(1): 33-35.
CornielloC.Quick dissolving strips: from concept to commercialization. Drug Del Technol. 2006; 6 (2): 68–71.
Londhe VY, Umalkar KB. Formulation development and evaluation of fast dissolving film of telmisartan. Ind J Pharm Sci. 2012; 74(2):122–126.
Maheswari KM, Devineni PK, Deekonda S, Shaik S, Uppala NP, Nalluri BN . Development and Evaluation of Mouth Dissolving Films of Amlodipine Besylate for Enhanced Therapeutic Efficacy. J of Pharmaceu. 2014: 1–10.
Bala R, Pawar P, Khanna S, Arora S. Orally dissolving strips: A new approach to oral drug delivery system. Int J Pharm Investig. 2013;3(2):67–76.
Panchal MS, Patel H, Bagada A,Vadalia KR. Formulation and Evaluation of Mouth Dissolving Film of Ropinirole Hydrochloride by Using Pullulan Polymers. Int J Pharm Res and Alli Sci. 2012; 1(3): 60-72
Pankaj Kumar, Ashok LG, Bharat BS, Shubhanjali S. Design and Comparative Evaluation of In-vitro Drug Release, Pharmacokinetics and Gamma Scintigraphic Analysis of Controlled Release Tablets Using Novel pH Sensitive Starch and Modified Starch- acrylate Graft Copolymer Matrices. Iran J Pharm Res. 2015; 14(3): 677–691.
Bala R, Khanna S, Pawar P. Design optimization and in vitro-in vivo evaluation of orally dissolving strips of clobazam. J Drug Deliv. 2014:3 92783.
Senthilkumar K, Vijaya C. Formulation Development of Mouth Dissolving Film of Etoricoxib for Pain Management. Adv in Pharmaceu. 2015:1–11.
Published
Abstract Display: 422 
PDF Downloads: 492 
