SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 2, 5-DISUBSTITUTED BENZIMIDAZOLE DERIVATIVES
Abstract
A new series of 2, 5 di-substituted benzimidazole derivatives have been synthesized. The structures of the synthesized compounds were confirmed by IR, 1H NMR and Mass spectral analysis and they were evaluated for their antibacterial; Proteus vulgaris (NCTC 4635), Klesibella pneumonia (ATCC 29655), Bacillus cereus (NL98), and Enterococcus faecium (ATCC 29212) and antifungal (Aspergillus niger and Aspergillus fumigatus) activities by disc diffusion method. All of the synthesized compounds showed good antibacterial and antifungal activity. However the antibacterial and antifungal activity of the synthesized compounds against the tested organisms was found to be less than that of respective standard drug at tested dose level.
Keywords:
O-phenylene diamine, Benzimidazole, Antibacterial, AntifungalDOI
https://doi.org/10.25004/IJPSDR.2012.040115References
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17. Raju B, Rahul R, Sivasankar BN. A New reagent for selective reduction of amino group. Indian J. Chem. 2009; 45B: 1315-1318.
2. Vijaya B, Rajeev K, Varadaraj G, Gautham G. Synthesis and antimicrobial studies of some novel benzimidazole derivatives. Asian. J. Research Chem. 2009; 2(2): 162-167.
3. Jadhav SB, Shastri RA, Bagul KR, Gaikwad KV. Synthesis and antimicrobial activity of N-substituted benzimidazoles. Indian J. Heterocyclic Chem. 2009; 18: 319-320.
4. Ganesh R, Mohammad U, Rajesh P, Deepak R. Synthesis of fluorobenzimidazoles as antimicrobial agents. Indian J. Heterocyclic Chem. 2009; 18: 419-420.
5. Gulgun A, Nurten A. Synthesis and antifungal properties of some benzimidazole deriovatives. Turk J. Chem. 2006; 30: 223-228.
6. Oztekin A, Nizami D, Gulay G. synthesis and evaluation of antimicrobial activity of some 1, 5(6)-H/or–Methyl-2-substituted benzimidazole derivatives. Asian J. Chem. 2007; 19(4): 3085-3092.
7. Shanmugapandian P, Denshing KS, Ilavarasan R, Anbalagan N, Nirmal R. Synthesis and biological activity of 2-(Thiazolidine-4-one) phenyl]-1h-phenylbenzimidazoles and 2-[4-(Azetidin-2-one)-3-chloro-4-Phenyl] - 1h-Phenylbenzimidazoles. International Journal of Pharmaceutical Sciences & Drug Research 2010; 2(2): 115-119.
8. Hasan K, Riza D, Nihat S, Selami. Synthesis, antibacterial and antifungal activities of new bis-5(6)-nitrobenzimidazoles. Asian J. Chem. 2010; 22(4): 2816-2824.
9. Leonard JT, Rajesh OS, Jeyaseeli L, Murugesh K. Synthesis, antiinflammatory and antibacterial activities of substituted phenylbenzimidazoles. Asian J. Chem. 2007; 19(1): 116-120.
10. Sreena K, Ratheesh R, Rachana M, Poornima M, Shyni C. Synthesis and anthelmenitic activity of benzimidazole derivatives. HYGEIA 2009; 1(1): 21, 22.
11. Simone B, Mariola K, Agata G, Zygmunt K, Henning E, Paolo C, Frank S. Substituted benzimidazoles: antiviral activity and synthesis of nucleosides. ARKIVOC 2009; 3: 225-250.
12. Ashish kumar T, Mishra A. Synthesis and antiviral activities of N-substituted-2-substituted-benzimidazole derivatives. Indian J. Chem. 2006; 45B: 489-493.
13. Starcevic K, Kralj M, Ester K, Sabol I, Grce M. Synthesis, antiviral and antitumor activity of 2-substituted-5-amidino benzimidazoles. Bioorg Med Chem 2007; 15(13): 4419-4426.
14. Vogel. Text book of Practical Organic Chemistry. Dorling Kindersley Publishers, 2006, 1162-1163.
15. Ahuluwalia VK, Agarwal R. Comprehensive Practical Organic Chemistry, University Press India Ltd, 2010, 120-121.
16. Singh J, Grover P, Pathak DP. Synthesis and Comparatrive QSAR study of some novel benzimidazole derivatives. Acta. Pharm. Sci. 2010; 52: 510-521.
17. Raju B, Rahul R, Sivasankar BN. A New reagent for selective reduction of amino group. Indian J. Chem. 2009; 45B: 1315-1318.
Published
01-01-2012
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“SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 2, 5-DISUBSTITUTED BENZIMIDAZOLE DERIVATIVES”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 1, Jan. 2012, pp. 80-83, https://doi.org/10.25004/IJPSDR.2012.040115.
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How to Cite
“SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 2, 5-DISUBSTITUTED BENZIMIDAZOLE DERIVATIVES”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 1, Jan. 2012, pp. 80-83, https://doi.org/10.25004/IJPSDR.2012.040115.
