EVALUATION OF ANTI-FERTILITY POTENTIAL OF AQUEOUS EXTRACT OF BOUGAINVILLEA SPECTABILIS LEAVES IN SWISS ALBINO MICE
Abstract
Population explosion is a major problem it is raising tremendously; this may affect drastically the economic growth. So
family planning has been promoted through several methods of contraception. A wide variety of synthetic contraceptive
agents are available, but these cannot be used continuously due to their side effects. Thus the present study was to evaluate
the effect of Bougainvillea spectabilis on fertility of male and female mice. Swiss Albino mice were orally administered
with aqueous crude extract of the leaves of Bougainvillea spectabilis (800 mg/kg of body weight/day, for 30 days), and
effect of crude extract on reproductive organs and fertility was investigated. The treatment Caused decrease in weight of
testis, sperm count and the histological examination revealed a reduction in the size of seminiferous tubules along with the
thickness of germinal epithelial cells, though some of the epithelial cells and interstitial cells of leydig showed
hypertrophy. Moreover, the lumen of the tubules was found to be devoid of sperms. On the other hand, in treated females
no histological changes could be observed. The only marked change, which could be visualized, was the slight disruption
of estrous cycle having prolonged metaestrus phase, which has been increased by 145.28 %. The overall duration of estrous
cycle had been extended by more than one day. The hormonal profile was also influenced by the Bougainvillea spectabilis
extract. The testosterone and estrogen levels were significantly decreased
Keywords:
Bougainvillea, estrogen, metaestrus, seminiferous tubules, sperms, testosterone, testisDOI
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