THE LIQUISOLID TECHNIQUE: BASED DRUG DELIVERY SYSTEM
Abstract
The “Liquisolid” technique is a novel and capable addition towards such an aims for solubility enhancement and dissolution improvement, thereby it increases the bioavailability. It contains liquid medications in powdered form. This technique is an efficient method for formulating water insoluble and water soluble drugs. This technique is based upon the admixture of drug loaded solutions with appropriate carrier and coating materials. The use of non-volatile solvent causes improved wettability and ensures molecular dispersion of drug in the formulation and leads to enhance solubility. By using hydrophobic carriers (non-volatile solvents) one can modify release (sustained release) of drugs by this technique. Liquisolid system is characterized by flow behavior, wettability, powder bed hydrophilicity, saturation solubility, drug content, differential scanning calorimetry, Fourier transform infra red spectroscopy, powder X-ray diffraction, scanning electron microscopy, in-vitro release and in-vivo evaluation. By using this technique, solubility and dissolution rate can be improved, sustained drug delivery systems be developed for the water soluble drugs.
Keywords:
Liquisolids, carriers, coating materials, water in-soluble/ soluble drugsDOI
https://doi.org/10.25004/IJPSDR.2012.040201References
1. Spireas S. Liquisolid System and method of preparing same. U.S Patent 6423339B1, 2002.
2. Merisko E. Liversidge nanocrystals: resolving pharmaceutical formulation issues associated with poorly soluble compounds in: J.J matty (Ed), Particles, Marcel Dekker, Orlando, 2002.
3. Jarowski CI, Rohera BD, Spireas S. Powdered solution technology: principles and mechanism. Pharm Res. 1992; 9: 1351-1358.
4. Barzegar JM, Javadzadeh Y, Nokhodchi A, Siahi-Shadbad MR. Enhancement of dissolution rate of piroxicam using liquisolid compacts. II Farmaco. 2005; 60: 361-365.
5. Nokhodchi A, Hentzschel CM, Leopord CS. Drug release from liquisolid system: speed it up, slow it down. Expert Opin Drug Del. 2011; 8: 191-205.
6. El-Houssieny BM, Wahman LF, Arafa NMS. Bioavailability and biological activity of liquisolid compact formula of repaglinide and its effect on glucose tolerance in rabbits. Bio Sci Trends. 2010; 4: 17-24.
7. Khaled KA, Asiri YA, El-Sayed YM. In-vivo evaluation of hydrochlorothiazide liquisolid tablet in beagles dogs. Int J Pharm. 2001; 222: 1-6.
8. Naseem A, Olliff CJ, Martini LG, Lloyd AW. Effects of plasma irradiation on the wettability and dissolution of compacts of griseofulvin. Int J Pharm.2004; 269, 443-450.
9. Setty CM, Prasad DVK, Gupta RM. Development of fast dispersible aceclofenac tablet: effect of functionality of super disintegrants. Indian J Pharm Sci. 2008; 70:180-185.
10. Yadav VB, Yadav AV. Liquisolid granulation technique for tablet manufacturing: An overview. Journal of Pharmacy Research 2009; 2(4):670-674.
11. Shah TJ, Amin AF, Parikh JR. Process optimization and characterization of poloxamer solid dispersions of a poorly water-soluble drug. AAPS Pharm SciTech. 2007; 8: E1-E7.
12. Aguiar AJ, Kinkel AW, Zelmer AJ. Deagglomeration behavior of relatively insoluble benzoic acid and its sodium salt. J Pharm. Sci.1979; 56: 1243-1252.
13. Finholt P, Solvang S. Dissolution kinetics of drugs in human gastric juice the role of surface tension. J Pharm. Sci.1968; 57:1322-1326.
14. Lin SL, Lachman L, Menig J. Interdependence of physiological surfactant and drug particle size on the dissolution behavior of water insoluble drugs. J Pharm. Sci.1968; 57: 2143-2146.
15. Ayres JW, Kapsi SG, Processing factors in development of solid solution formulation of Itraconazole for enhancement of drug dissolution and bioavailability. Int J Pharm. 2001; 229: 193-203.
16. Jafari NB, Javadzadeh Y, Nokhodchi A. Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug Carbamazepine. Int J Pharm. 2007; 341: 26-34.
17. Javadzadeh Y, Musaalrezaei L, Nokhodchi A. Liquisolid technique as a new approach to sustained propranolol hydrochloride release from tablet matrices. Int J Pharm. 2008; 362:102-108.
18. Kavitha K, Kotha NS, Raja L, Ganesh NS, Ramesh B. Effect of dissolution rate by Liquisolid Compact Approach: An Overview. Der Pharma Lettre 2011; 3: 71-83.
19. Spiro S, Srinivas S. Enhancement of Prednisolone dissolution properties using liquisolid compacts. Int J Pharm. 1998; 166:177-188.
20. Fahmy RH, Kassem MA. Enhancement of Famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation. Eur J Pharm. Biopharm. 2008; 69: 993-1003.
21. Asnaashari S, Javadzadeh Y, Nokhodchi A, Siahi M R. Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical properties. Acta Pharm. 2007; 57: 99-109.
22. Barzegar JM, Javadzadeh Y, Nokhodchi A, Siahi-Shadbad MR. The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug Indomethacin from liquisolid compacts. J Pharm Sci. 2005; 8: 18-25.
23. Sadu S, Spireas S, Grover R. In vitro release evaluation of hydrocortisone liquisolid tablets. J Pharm Sci. 1998; 87:867–872.
24. Spireas S, Bolton S. Sustained-release liquisolid Compacts. Proc Int Symp Control Rel Bio act Mater. 1998; 25: 138-139.
25. Bolton SM, Spireas S. Liquisolid systems and methods of preparing same, US Patent, 1999, 550: 5968
26. Spireas S. Liquisolid systems and methods for preparing same, United States patent, 6, 423, 339 B1, 2002.
27. Shinde AJ. Solubilization of poorly soluble drugs: A review, available at http://www.pharmainfo.net/reviews/solubilization-poorly-soluble-drugs-review 2007.
28. Indrajeet DG, Amirit BK, Hosmani AH. Evaluation of in vitro dissolution profile comparison methods of sustained release Tramadol hydrochloride liquisolid compact formulations with marketed sustained release tablets. Digest Journal of Nano materials and Bio structures 2009; 651-661.
29. Amrit BK, Indrajeet DG, Hosmani AH, Dhabale PN. Evaluation of in vitro dissolution profile comparison methods of sustained release Tramadol hydrochloride liquisolid compact formulations with marketed sustained release tablets. Drug Discoveries & Therapeutics 2010; 4(1): 26-32.
30. Ferrari F. Investigation on Bonding and Disintegration Properties of Pharmaceutical Materials. Int J Pharm. 1996; 136: 71-79.
31. Sanjeev RG, Jarag R. Formulation and characterization of atorvastatin calcium liquisolid compacts. Asian J Pharm Sciences 2010; 5(2): 50-60.
32. Bhise SB, Nighute AB, Yadav AV, Yadav VB. Aceclofenac size enlargement by non aqueous granulation with improved solubility and dissolution. Arch Pharm Sci & Res. 2009; 1: 115-122.
33. Yadav VB, Yadav AV. Improvement of Solubility and Dissolution of Indomethacin by Liquisolid and Compaction Granulation Technique. J Pharm Sci & Res. 2009; 44-51.
34. Alebiowu G, OA Itiola. Effects of Natural and Pregelatinized Sorghum, Plantain, and Corn Starch Binders on the Compressional Characteristics of a Paracetamol Tablet Formulation Drug Delivery. A Pharm Technol. 2001; 25: 26-30.
35. Ajit SK, Nagesh H, Aloorkar, Madhav S, Mane, Gaja JB. Liquisolid systems: a review: Int J of Pharm Sciences and Nanotech. 2010; (3) 1: 795-802.
36. Fahmy RH, Kassem MA. Enhancement of Famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation. Eur J Pharm Biopham. 2008; 69: 993-1003.
37. Grover R, Spireas S, Wang T. Effect of powder substrate on the dissolution properties of Methchrothiazide liquisolid compacts. Drug Dev Ind Pharm. 1999; 25: 163-168.
38. Furer R, Geiger M. A simple method of determining the aqueous solubility of organic substances. J Pharm Sci. 1976; 8(4):337-344.
39. Banker GS, Anderson NL. Tablets. In: The theory and practice of industrial pharmacy. Lachman L, Liberman HA, Kanig JL. edn. 3rd. Varghese Publishing House, Bombay, India, 1987; 293-345.
40. Ghorab MM, Salam HM, El-Sayad MA. Tablet formulation containing meloxicam and β-cyclodextrin: mechanical characterization and bioavailability evaluation. AAPS Pharm Sci Tech. 2004; 5: 1-6.
41. Li XS, Wang JX, Shen ZG, et al. Preparation of uniform Prednisolone micro crystals by a controlled micro precipitation method. Int J Pharm. 2007; 342: 26-32.
42. Liao CC, Jarowski CI. Dissolution rates of corticoid solutions dispersed on silicas. J Pharm Sci. 1984; 73: 401-403.
43. Nazzal S, Khan MA. Controlled release of a self-emulsifying formulation from a tablet dosage form: Stability assessment and optimization of some processing parameters. Int J Pharm. 2006; 315: 110-121.
44. Grover R, Spireas S, Wang T. Effect of powder substrate on the dissolution properties of Methchrothiazide liquisolid compacts. Drug Dev Ind Pharm. 1999; 25: 163-168.
45. Bolton S, Spireas S. Sustained-release liquisolid compacts. In: 25th International Symposium on Controlled Release of Bioactive Materials., Nevada, USA, 1998, 138-139.
46. Staniforth J. Powder flow, in: M. Aulton, Pharmaceutics: the Science of Dosage Form Design, Edinburgh, 2002, pp. 197–210.
47. Wells J. Pharmaceutical Preformulation: The physicochemical properties of drug substances, In: Aulton M, Pharmaceutics: the Science of Dosage Form Design, Edinburgh, 2002, pp.114-138.
48. Bhise SB, Nighute AB, Yadav AV, Yadav VB, Aceclofenac size enlargement by non aqueous granulation with improved solubility and dissolution. Arch Pharm Sci & Res. 2009; 1:115-122.
49. Craig DQM. Pharmaceutical applications of DSC. In: Craig DQM, Reading M (eds). Thermal analysis of pharmaceuticals. Boca Raton, USA, CRC Press, 2007, pp. 53-99.
50. Asnaashari S, Javadzadeh Y, Siahi MR., A. Nokhodchi, An investigation of physicochemical properties of piroxicam liquisolid compacts. Pharm Develop Tech. 2007; 12: 337–343.
51. Rakshit P, Ridhish P, Moinuddin S. Formulation and evaluation of liquisolid compacts of piroxicam. Ind drugs. 2007; 44: 967-972.
52. Tayel SA, Louis D, Soliman V. Improvement of dissolution properties of carbamazepine through application of the liquisolid tablet technique. Eur J Pharm Bio pharm. 2008; 69: 342-347.
53. Martindale, The Complete Drug Reference, 6 Edn, The Pharmaceutical Press, London, 1999, pp. 937.
54. Gil EC, Colarte AI, Bataille B, Pedraz JL, Rodriguez F, Heinamaki J. Development and optimization of a novel sustained- release dextran tablets formulation for Propranolol hydrochloride. Int J Pharm. 2006; 317: 32-39.
55. El-Say KM, Ahmed MS, Mohamed IF. Formulation and evaluation of Rofecoxib liquisolid tablets. Int J Pharm Sci Review & Res. 2010; 3(1): 28.
56. Tiong N, Amal AE. Effects of liquisolid formulations on dissolution of Naproxen. Euro Journal of Pharm & Biopharm. 2009; 73: 373-384.
57. Sanjeev G, Ravindra J. Liquisolid technique for enhancement of dissolution properties of Bromhexine hydrochloride. Research J Pharm & Tech. 2009; 2(2): 382-386.
58. Kamarkar AB, Gonjari ID, Hosmani AH, Dhabale PN, Bhise SB. Liquisolid tablets: a novel approach for drug delivery. Int. J. Health Res. Int J Health Res, 2009; 2: 45-50.
59. Zhao YQ, Zhou S, Potharaju H, Lou HM, Brunson E, Almoazen H, Johnson J. Development of a self micro-emulsifying tablet of Cyclosporine- A by the liquisolid compact technique. IJPSR, 2011; 2(9): 2299-2308.
60. Gubbi SR, Jarag R. Formulation and characterization of Atorvastatin calcium liquisolid Compacts. Asian J Pharm Sci. 2010; 2:50-60.
61. El-Houssieny BM, Wahman LF, Arafa NMS. Bioavailability and biological activity of liquisolid Compact formula of repaglinide and its effect on glucose tolerance in rabbits. Biosci Trends 2010; 4: 17-24.
62. Elkordy AA, Akinlade B, Ebtessam A. Essa, Sahar E. Liquisolid Systems to Improve the Dissolution of Furosemide. Sci Pharm. 2010; 78: 325–344.
63. El-say KM, Samy AH, Fetouh MI. Formulation and Evaluation of oral dispersible Liquisolid Compacts of Aceclofenac. Int J Pharm Sci Rev Res 2010; 3:135-142.
64. Louis D, Saadia A, Tayel, Iman I, Soliman. Formulation of Ketotifen Fumarate Fast-Melt Granulation Sublingual Tablet. AAPS Pharm SciTech. 2010; 11 (2):679-685.
2. Merisko E. Liversidge nanocrystals: resolving pharmaceutical formulation issues associated with poorly soluble compounds in: J.J matty (Ed), Particles, Marcel Dekker, Orlando, 2002.
3. Jarowski CI, Rohera BD, Spireas S. Powdered solution technology: principles and mechanism. Pharm Res. 1992; 9: 1351-1358.
4. Barzegar JM, Javadzadeh Y, Nokhodchi A, Siahi-Shadbad MR. Enhancement of dissolution rate of piroxicam using liquisolid compacts. II Farmaco. 2005; 60: 361-365.
5. Nokhodchi A, Hentzschel CM, Leopord CS. Drug release from liquisolid system: speed it up, slow it down. Expert Opin Drug Del. 2011; 8: 191-205.
6. El-Houssieny BM, Wahman LF, Arafa NMS. Bioavailability and biological activity of liquisolid compact formula of repaglinide and its effect on glucose tolerance in rabbits. Bio Sci Trends. 2010; 4: 17-24.
7. Khaled KA, Asiri YA, El-Sayed YM. In-vivo evaluation of hydrochlorothiazide liquisolid tablet in beagles dogs. Int J Pharm. 2001; 222: 1-6.
8. Naseem A, Olliff CJ, Martini LG, Lloyd AW. Effects of plasma irradiation on the wettability and dissolution of compacts of griseofulvin. Int J Pharm.2004; 269, 443-450.
9. Setty CM, Prasad DVK, Gupta RM. Development of fast dispersible aceclofenac tablet: effect of functionality of super disintegrants. Indian J Pharm Sci. 2008; 70:180-185.
10. Yadav VB, Yadav AV. Liquisolid granulation technique for tablet manufacturing: An overview. Journal of Pharmacy Research 2009; 2(4):670-674.
11. Shah TJ, Amin AF, Parikh JR. Process optimization and characterization of poloxamer solid dispersions of a poorly water-soluble drug. AAPS Pharm SciTech. 2007; 8: E1-E7.
12. Aguiar AJ, Kinkel AW, Zelmer AJ. Deagglomeration behavior of relatively insoluble benzoic acid and its sodium salt. J Pharm. Sci.1979; 56: 1243-1252.
13. Finholt P, Solvang S. Dissolution kinetics of drugs in human gastric juice the role of surface tension. J Pharm. Sci.1968; 57:1322-1326.
14. Lin SL, Lachman L, Menig J. Interdependence of physiological surfactant and drug particle size on the dissolution behavior of water insoluble drugs. J Pharm. Sci.1968; 57: 2143-2146.
15. Ayres JW, Kapsi SG, Processing factors in development of solid solution formulation of Itraconazole for enhancement of drug dissolution and bioavailability. Int J Pharm. 2001; 229: 193-203.
16. Jafari NB, Javadzadeh Y, Nokhodchi A. Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug Carbamazepine. Int J Pharm. 2007; 341: 26-34.
17. Javadzadeh Y, Musaalrezaei L, Nokhodchi A. Liquisolid technique as a new approach to sustained propranolol hydrochloride release from tablet matrices. Int J Pharm. 2008; 362:102-108.
18. Kavitha K, Kotha NS, Raja L, Ganesh NS, Ramesh B. Effect of dissolution rate by Liquisolid Compact Approach: An Overview. Der Pharma Lettre 2011; 3: 71-83.
19. Spiro S, Srinivas S. Enhancement of Prednisolone dissolution properties using liquisolid compacts. Int J Pharm. 1998; 166:177-188.
20. Fahmy RH, Kassem MA. Enhancement of Famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation. Eur J Pharm. Biopharm. 2008; 69: 993-1003.
21. Asnaashari S, Javadzadeh Y, Nokhodchi A, Siahi M R. Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical properties. Acta Pharm. 2007; 57: 99-109.
22. Barzegar JM, Javadzadeh Y, Nokhodchi A, Siahi-Shadbad MR. The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug Indomethacin from liquisolid compacts. J Pharm Sci. 2005; 8: 18-25.
23. Sadu S, Spireas S, Grover R. In vitro release evaluation of hydrocortisone liquisolid tablets. J Pharm Sci. 1998; 87:867–872.
24. Spireas S, Bolton S. Sustained-release liquisolid Compacts. Proc Int Symp Control Rel Bio act Mater. 1998; 25: 138-139.
25. Bolton SM, Spireas S. Liquisolid systems and methods of preparing same, US Patent, 1999, 550: 5968
26. Spireas S. Liquisolid systems and methods for preparing same, United States patent, 6, 423, 339 B1, 2002.
27. Shinde AJ. Solubilization of poorly soluble drugs: A review, available at http://www.pharmainfo.net/reviews/solubilization-poorly-soluble-drugs-review 2007.
28. Indrajeet DG, Amirit BK, Hosmani AH. Evaluation of in vitro dissolution profile comparison methods of sustained release Tramadol hydrochloride liquisolid compact formulations with marketed sustained release tablets. Digest Journal of Nano materials and Bio structures 2009; 651-661.
29. Amrit BK, Indrajeet DG, Hosmani AH, Dhabale PN. Evaluation of in vitro dissolution profile comparison methods of sustained release Tramadol hydrochloride liquisolid compact formulations with marketed sustained release tablets. Drug Discoveries & Therapeutics 2010; 4(1): 26-32.
30. Ferrari F. Investigation on Bonding and Disintegration Properties of Pharmaceutical Materials. Int J Pharm. 1996; 136: 71-79.
31. Sanjeev RG, Jarag R. Formulation and characterization of atorvastatin calcium liquisolid compacts. Asian J Pharm Sciences 2010; 5(2): 50-60.
32. Bhise SB, Nighute AB, Yadav AV, Yadav VB. Aceclofenac size enlargement by non aqueous granulation with improved solubility and dissolution. Arch Pharm Sci & Res. 2009; 1: 115-122.
33. Yadav VB, Yadav AV. Improvement of Solubility and Dissolution of Indomethacin by Liquisolid and Compaction Granulation Technique. J Pharm Sci & Res. 2009; 44-51.
34. Alebiowu G, OA Itiola. Effects of Natural and Pregelatinized Sorghum, Plantain, and Corn Starch Binders on the Compressional Characteristics of a Paracetamol Tablet Formulation Drug Delivery. A Pharm Technol. 2001; 25: 26-30.
35. Ajit SK, Nagesh H, Aloorkar, Madhav S, Mane, Gaja JB. Liquisolid systems: a review: Int J of Pharm Sciences and Nanotech. 2010; (3) 1: 795-802.
36. Fahmy RH, Kassem MA. Enhancement of Famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation. Eur J Pharm Biopham. 2008; 69: 993-1003.
37. Grover R, Spireas S, Wang T. Effect of powder substrate on the dissolution properties of Methchrothiazide liquisolid compacts. Drug Dev Ind Pharm. 1999; 25: 163-168.
38. Furer R, Geiger M. A simple method of determining the aqueous solubility of organic substances. J Pharm Sci. 1976; 8(4):337-344.
39. Banker GS, Anderson NL. Tablets. In: The theory and practice of industrial pharmacy. Lachman L, Liberman HA, Kanig JL. edn. 3rd. Varghese Publishing House, Bombay, India, 1987; 293-345.
40. Ghorab MM, Salam HM, El-Sayad MA. Tablet formulation containing meloxicam and β-cyclodextrin: mechanical characterization and bioavailability evaluation. AAPS Pharm Sci Tech. 2004; 5: 1-6.
41. Li XS, Wang JX, Shen ZG, et al. Preparation of uniform Prednisolone micro crystals by a controlled micro precipitation method. Int J Pharm. 2007; 342: 26-32.
42. Liao CC, Jarowski CI. Dissolution rates of corticoid solutions dispersed on silicas. J Pharm Sci. 1984; 73: 401-403.
43. Nazzal S, Khan MA. Controlled release of a self-emulsifying formulation from a tablet dosage form: Stability assessment and optimization of some processing parameters. Int J Pharm. 2006; 315: 110-121.
44. Grover R, Spireas S, Wang T. Effect of powder substrate on the dissolution properties of Methchrothiazide liquisolid compacts. Drug Dev Ind Pharm. 1999; 25: 163-168.
45. Bolton S, Spireas S. Sustained-release liquisolid compacts. In: 25th International Symposium on Controlled Release of Bioactive Materials., Nevada, USA, 1998, 138-139.
46. Staniforth J. Powder flow, in: M. Aulton, Pharmaceutics: the Science of Dosage Form Design, Edinburgh, 2002, pp. 197–210.
47. Wells J. Pharmaceutical Preformulation: The physicochemical properties of drug substances, In: Aulton M, Pharmaceutics: the Science of Dosage Form Design, Edinburgh, 2002, pp.114-138.
48. Bhise SB, Nighute AB, Yadav AV, Yadav VB, Aceclofenac size enlargement by non aqueous granulation with improved solubility and dissolution. Arch Pharm Sci & Res. 2009; 1:115-122.
49. Craig DQM. Pharmaceutical applications of DSC. In: Craig DQM, Reading M (eds). Thermal analysis of pharmaceuticals. Boca Raton, USA, CRC Press, 2007, pp. 53-99.
50. Asnaashari S, Javadzadeh Y, Siahi MR., A. Nokhodchi, An investigation of physicochemical properties of piroxicam liquisolid compacts. Pharm Develop Tech. 2007; 12: 337–343.
51. Rakshit P, Ridhish P, Moinuddin S. Formulation and evaluation of liquisolid compacts of piroxicam. Ind drugs. 2007; 44: 967-972.
52. Tayel SA, Louis D, Soliman V. Improvement of dissolution properties of carbamazepine through application of the liquisolid tablet technique. Eur J Pharm Bio pharm. 2008; 69: 342-347.
53. Martindale, The Complete Drug Reference, 6 Edn, The Pharmaceutical Press, London, 1999, pp. 937.
54. Gil EC, Colarte AI, Bataille B, Pedraz JL, Rodriguez F, Heinamaki J. Development and optimization of a novel sustained- release dextran tablets formulation for Propranolol hydrochloride. Int J Pharm. 2006; 317: 32-39.
55. El-Say KM, Ahmed MS, Mohamed IF. Formulation and evaluation of Rofecoxib liquisolid tablets. Int J Pharm Sci Review & Res. 2010; 3(1): 28.
56. Tiong N, Amal AE. Effects of liquisolid formulations on dissolution of Naproxen. Euro Journal of Pharm & Biopharm. 2009; 73: 373-384.
57. Sanjeev G, Ravindra J. Liquisolid technique for enhancement of dissolution properties of Bromhexine hydrochloride. Research J Pharm & Tech. 2009; 2(2): 382-386.
58. Kamarkar AB, Gonjari ID, Hosmani AH, Dhabale PN, Bhise SB. Liquisolid tablets: a novel approach for drug delivery. Int. J. Health Res. Int J Health Res, 2009; 2: 45-50.
59. Zhao YQ, Zhou S, Potharaju H, Lou HM, Brunson E, Almoazen H, Johnson J. Development of a self micro-emulsifying tablet of Cyclosporine- A by the liquisolid compact technique. IJPSR, 2011; 2(9): 2299-2308.
60. Gubbi SR, Jarag R. Formulation and characterization of Atorvastatin calcium liquisolid Compacts. Asian J Pharm Sci. 2010; 2:50-60.
61. El-Houssieny BM, Wahman LF, Arafa NMS. Bioavailability and biological activity of liquisolid Compact formula of repaglinide and its effect on glucose tolerance in rabbits. Biosci Trends 2010; 4: 17-24.
62. Elkordy AA, Akinlade B, Ebtessam A. Essa, Sahar E. Liquisolid Systems to Improve the Dissolution of Furosemide. Sci Pharm. 2010; 78: 325–344.
63. El-say KM, Samy AH, Fetouh MI. Formulation and Evaluation of oral dispersible Liquisolid Compacts of Aceclofenac. Int J Pharm Sci Rev Res 2010; 3:135-142.
64. Louis D, Saadia A, Tayel, Iman I, Soliman. Formulation of Ketotifen Fumarate Fast-Melt Granulation Sublingual Tablet. AAPS Pharm SciTech. 2010; 11 (2):679-685.
Published
01-04-2012
Statistics
Abstract Display: 522 
PDF Downloads: 784
Dimension Badge
How to Cite
“THE LIQUISOLID TECHNIQUE: BASED DRUG DELIVERY SYSTEM”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 2, Apr. 2012, pp. 88-96, https://doi.org/10.25004/IJPSDR.2012.040201.
Issue
Section
Review Article
How to Cite
“THE LIQUISOLID TECHNIQUE: BASED DRUG DELIVERY SYSTEM”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 2, Apr. 2012, pp. 88-96, https://doi.org/10.25004/IJPSDR.2012.040201.
