ANTI-INFLAMMATORY ACTIVITY OF CRINUM DEFIXUM KER-GAWL
Abstract
Crinum defixum Ker-Gawl is a bulbous herb which has a wide geographical distribution in India. It is commonly called Bon-naharu (meaning wild garlic) in Assam. Traditionally the bulb has been reported to have nauseant, emetic, emollient, diaphoretic properties and it is also used in various inflammatory conditions. The anti-inflammatory activity of the bulbs of the plants has been investigated in the present study in order to establish its traditional claims. The ethyl acetate, chloroform and ethanol extracts of bulbs of Crinum defixum were screened for anti-inflammatory activity by using carrageenan induced rat paw edema method. The study revealed that the ethyl acetate extract of the plant had significant anti-inflammatory activity than the chloroform and ethanol extracts. The study supports the ethanomedicinal use of this plant for inflammatory conditions.
Keywords:
Nonsteroidal anti-inflammatory drugs, Crinum defixum Ker- Gawl, Carrageenan, Extracts of bulbsDOI
https://doi.org/10.25004/IJPSDR.2012.040213References
2. Hooker JD, Flora of British India, Published under the authority of the Secretary of State for India in Council, 1954
3. Madhava CK, Shivaji K, Tulasi RK. Flowering Plants of Chittoor district. Students Offset Printers, 2008.
4. Guha BDN, Sensarma P, Pal DC. A Lexicon of Medicinal plants In India. Naya Prakash publishers, 1999.
5. Trivedi PC. Indian folk Medicine. Pointer publishers, 2007
6. Kirtikar KR, Basu BD. Indian Medicinal Plants, M/S Bishen Singh Mohendra Pal Sing publishers, 1975.
7. Boit HG, Dopke W, Stender W. Alkaloids from species of Crinum, Zephyranthes, Leucojum and Clivia. Chem Ber. 1957; 90: 2203-2206.
8. Jeffs PW, Abou-Donia A, Campau D, Staiger D. Structures of 9- O -demethyl-homolycorine and 5 α -hydroxyhomolycorine. Alkaloids of Crinum defixum, C. scabrum and C. latifolium Assignment of aromatic substitution patterns from 1H-coupled 13 C spectra. J Org Chem. 1985; 50: 1732-1737
9. Manobjyoti B, Rumi K, Jiban JM, Tarun CS, Purnendu BK. Anti-genotoxic hydrazide from Crinum defixum. Eur J Med Chem. 2009; 44: 2754-2757.
10. Wagner H, Bladt S. Plant drug analysis. A Thin Layer Chromatography Atlas. Springer publishers, 2004
11. OECD: Guidline, 423, acute oral toxicity: Enivronmetal Health and Safety Monograph series on Testing and Assessment no. 24, 2000.
12. Winter CA, Risley EA, Nuss GW. Carrageenan-induced paw oedema in hind paw of the rat as an assay for anti-inflammatory drugs. P Soc Exp Biol Med. 1962; 111: 544-547.
13. Ashis K, Samanta SK, Panda BR, Nanda U. Free radical scavenging and analgesic properties of ethanolic bulb extract of Crinum defixum Ker-Gawl on experimental animal model. Inter J Biol Pharm Res. 2010; 1: 82-87.
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