EFFECT OF AQUEOUS FLOWER EXTRACT OF CATHARANTHUS ROSEUS ON ALLOXAN INDUCED DIABETES IN MALE ALBINO RATS
Abstract
Catharanthus roseus is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. The present study was carried out to investigate the antidiabetic and hyperlipidemic potential of Catharanthus roseus on alloxan induced diabetes in male albino rats. Oral administration of aqueous extract of Catharanthus roseus at a dose of 250 mg, 350 mg, and 450 mg/kg body weight for 30 days to diabetic rats resulted in significant reduction in blood glucose, reduction in lipid profile and also prevented a decrease in body weight. Histological observation demonstrated significant fatty changes and inflammatory cell infiltrates in pancreas of diabetic rats. But, supplementation with Catharanthus roseus to diabetic rats significantly reduced the fatty changes and inflammatory cell infiltrates.
Keywords:
Catharanthus roseus, alloxan, hyperglycemia, hyperlipidemiaDOI
https://doi.org/10.25004/IJPSDR.2012.040214References
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17. Sreepriya M, Bali G. Effects of administration of embelin and curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats. Mol Cellular Biochem. 2006; 284: 49-55.
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21. Sperling MA, Saunders PA. Diabetes mellitus in: Behrman RM, sKliegman HB. Jenson (Eds) Nelson text book of pediatrics, 2000, pp. 1767-1791.
22. Bhagavan NV. Metabolic homeostasis in: N.V. Bhagavan (Eds) Medical biochem Harcourt/Academic, Florida 2002; 485-519.
23. Ranganathan G, Li C, Kern PA. The translational regulation of lipoprotein lipase indiabetic rats involves the 3’-untransalted region of lipoprotein lipase mRNA. J Biol Chem. 2000; 275(40): 986-40991.
24. Ginsberg HN. Lipoprotein physiology in nondiabetic and diabetic states. Relationship to atherogenesis. Diabetes care. 1991; 14: 839-855.
25. Coppack SW, Jenson MD, Miles JM. In-vivo regulation of lipolysis in human. J lipid Res. 1994; 35: 177-193.
26. Ohno T, Horio F, Tanaka S, Terada M, Namikawa T, kitoh J. Fatty liver and hyperlipidemia in IDDM of streptozotocin treated shrews. Life Sci. 2000; 66: 125-131.
27. Bopanna KN, Kannan J, Sushma gangil, Balaraman R, Rathod SP. Anti-diabetic and anti-hyperlipidemic effect of Neem, Lipidemic effect of Neem seed kernel powder on alloxon diabetic rabbits. Ind J Pharmacol. 1997; 29: 162-167.
2. Sharma B, Balomajumder C, Roy P. Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food and Chemical Toxicology 2008; 46: 2376-2383.
3. Kesari AN, Gupta RK, Singh SK, Diwakar S, Watal G. Hypoglycemic and antihyperglycemic activity of Aegle marmelos seed extract in normal and diabetic rats. Journal of Ethnopharmacology 2006; 107: 374-379.
4. Sepici A, Gürbüz I, Çevik C, Yesilada E. Hypoglycaemic effects of myrtle oil in normal and alloxan-diabetic rabbits. Journal of Ethnopharmacology 2004; 93: 311-318.
5. Sivaraj A, Devi K, Palani SP, Vinoth Kumar P, Senthil Kumar B, David E. Anti-hyperglycemic and Anti-hyperlipidemic effect of combined plant extract of Cassia auriculata and Aegle marmelose in streptozotocin (STZ) induced diabetic albino rats. Int J Pharm Tech Res. 2009; 1(4):1010-1016.
6. Eddouks M, Maghrani M, Michel JB. Hypoglycemic effect of Triticumrepens P. Beauv in normal and diabetic rats. Journal of Ethnopharmacology 2005; 102: 228-232.
7. Bailey LJ, Day C. Traditional plant medicine as treatment for diabetes. Diab Care. 1989; 12: 553-564.
8. Huxley A. New RHS Dictionary of Gardening. Macmillan ISBN. 1992; 0-333-47494-5.
9. Zi-Qian C, Yao-Qing T, Zhang Y, Zhi-Hong J, En-Qiang M, Wei-Guo Z, Ruo-Qing L, Tian-Quan H, Sheng-Dao Z. Adenoviral transfer of human interleukin-10 gene in lethal pancreatitis. World Journal of Gastroenterology 2004; 10(20): 3021-3025.
10. Hayashida CY, Suzuki K, Fujika H, Koizumi M, Toyota T, Goto Y. Morp metrical quantization of pancreatic endocrine cells in patients with carcinoma of the pancreas. Tohoku J. Exp. Med. 1983; 141:311-322.
11. Pandey VN. Pharmacological investigation of certain medicinal plants and compound formulations used in Ayurveda and Siddha, Central Council for Research in Ayurveda and Siddha. New Delhi, India: Yugantar Press, 1996, pp. 370-376.
12. Vaidya Arya MR. Sthaulya Cikitsa. (treatment of obesity) In: A Compendium of Ayurvedic Medicine, Principles and Practice, Sri Satyaguru Publication. New Delhi, India: A division of Indian Book Centre, 1999, pp. 335-339.
13. Joshi R, Kamat JP, Mukherjee T. Free radical scavenging reactions and antioxidant activity of embelin: biochemical and pulse radiolytic studies. Chemico Biol Interact. 2007; 167:125-134.
14. Dharmendra S, Ruchi S, Pahup S, Gupta RS. Effect of embelin on lipid peroxidation and free radical scavanging activity against liver damage in rats. Basic Clin Pharmacol Toxicol. 2009; 105: 243-248.
15. Bhandari U, Jain N, Pillai KK. Further studieson antioxidant potential and protection of pancreatic b-cells by Embelia ribes in experimental diabetes. eXP Diabetes Res. 2007; 1-6.
16. Bhandari U, Jain N, Ansari MN, Pillai KK. Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin induced diabetes in rats. Fitoterapia 2008; 79:351-355.
17. Sreepriya M, Bali G. Effects of administration of embelin and curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats. Mol Cellular Biochem. 2006; 284: 49-55.
18. Ogbonnia SO, Odimegwu JI, Enwuru VN. Evaluation of hypoglycemic and hypolipidemic effects of ethanolic extracts of Treculia africana Decne and Bryophyllum pinnatum Lam. and their mixture on streptozotocin (STZ) - induced diabetic rats. African Journal of Biotech. 2008; 7(15): 2535-2539.
19. Flodstrom M, Tyrberg B, Eizirik DL, Sandler S. Reduced sensitivity of inducible nitric oxide synthetase-deficient mice to multiple low-dose streptozotocin induced diabetes. Diabetes 1999; 48(4): 706-713.
20. Rao VS, Santos FA, Silva RM, Teixiera MG. Effects of nitric oxide synthetase inhibitor and melatonin on the hyperglycemic response to streptozotocin in rats. Vascul Pharmacol. 2002; 38(3): 127-130.
21. Sperling MA, Saunders PA. Diabetes mellitus in: Behrman RM, sKliegman HB. Jenson (Eds) Nelson text book of pediatrics, 2000, pp. 1767-1791.
22. Bhagavan NV. Metabolic homeostasis in: N.V. Bhagavan (Eds) Medical biochem Harcourt/Academic, Florida 2002; 485-519.
23. Ranganathan G, Li C, Kern PA. The translational regulation of lipoprotein lipase indiabetic rats involves the 3’-untransalted region of lipoprotein lipase mRNA. J Biol Chem. 2000; 275(40): 986-40991.
24. Ginsberg HN. Lipoprotein physiology in nondiabetic and diabetic states. Relationship to atherogenesis. Diabetes care. 1991; 14: 839-855.
25. Coppack SW, Jenson MD, Miles JM. In-vivo regulation of lipolysis in human. J lipid Res. 1994; 35: 177-193.
26. Ohno T, Horio F, Tanaka S, Terada M, Namikawa T, kitoh J. Fatty liver and hyperlipidemia in IDDM of streptozotocin treated shrews. Life Sci. 2000; 66: 125-131.
27. Bopanna KN, Kannan J, Sushma gangil, Balaraman R, Rathod SP. Anti-diabetic and anti-hyperlipidemic effect of Neem, Lipidemic effect of Neem seed kernel powder on alloxon diabetic rabbits. Ind J Pharmacol. 1997; 29: 162-167.
Published
01-04-2012
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“EFFECT OF AQUEOUS FLOWER EXTRACT OF CATHARANTHUS ROSEUS ON ALLOXAN INDUCED DIABETES IN MALE ALBINO RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 2, Apr. 2012, pp. 150-3, https://doi.org/10.25004/IJPSDR.2012.040214.
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How to Cite
“EFFECT OF AQUEOUS FLOWER EXTRACT OF CATHARANTHUS ROSEUS ON ALLOXAN INDUCED DIABETES IN MALE ALBINO RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 2, Apr. 2012, pp. 150-3, https://doi.org/10.25004/IJPSDR.2012.040214.
