ASSESSMENT OF FLAVONOID RELEASE WITH DIFFERENT PERMEATION ENHANCERS
Abstract
The aim of the study was to evaluate the effect of different permeation enhancers in the transdermal permeation of flavonoids. A weed plant named Chromolaena odorata have been employed as the flavonoid source. Six different cream formulations have been prepared with the Chromolaena extract using different permeation enhancers such as ethanol, dimethyl sulphoxide, surfactants and occlusive agents. The amount of flavonoids penetrated during a time period of four hours was noted. The highest amount of penetration was obtained with the formulation no 6 which contained a combination of different permeation enhancers. The result suggests that a synergistic combination of different permeation enhancers can be adopted for enhancement of permeation of flavonoids in topical drug delivery systems.
Keywords:
Chromolaena odorata, flavonoids, Permeation enhancers, In-vitro skin permeation study, total flavonoid content analysisDOI
https://doi.org/10.25004/IJPSDR.2012.040215References
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2. Ogunbiyi, Aruboula EA, Soladoye AO. Analgesic, anti-inflammatory and antipyretic activities from flavonoid fractions of Chromolaena odorata. Journal of Medicinal Plants Research 2008; 2(9): 219-225.
3. Pisutthanan N, Liawruangrath S, Bremner JB, Liawruangrath B. Chemical Constituents and Biological Activities of Chromolaena odorata. Chiang Mai J. Sci. 2005; 32(2): 139-148.
4. Suksamrarn A, Chotipong A, Suavansri T, Boongird S, Timsuksai P, Vimuttipong S, Chuaynugul A. Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata. Arch Pharm Res. 2004; 27(5): 507-511.
5. Taleb-Contini SH, Salvador MJ, Watanabe E, Yoko Ito I, Rodrigues de Oliveira DC. Antimicrobial activity of flavonoids and steroids isolated from two Chromolaena species. Brazilian Journal of Pharmaceutical Sciences. 2003; 39(4): 403-408.
6. Williams AC, Barry BW. Penetration enhancers. Advanced Drug Delivery Reviews 2004; 56: 603-618.
7. Finnin BC, Morgan TM. Transdermal penetration enhancers: Applications, limitations, and potential. Journal of Pharmaceutical Sciences 1999; 88(10): 955.
8. Moser K, Krivet K, Naik A, Kalia YN, Guy RH. Passive skin penetration enhancement and its quantification in vitro. European Journal of Pharmaceutics and Biopharmaceutics 2001; 52: 103-112.
9. Pathan IB, Setty CM. Chemical Penetration Enhancers for Transdermal Drug Delivery Systems. Tropical Journal of Pharmaceutical Research 2009; 8 (2): 173-179.
10. Hadgraft J. Passive enhancement strategies in topical and transdermal drug delivery. International Journal of Pharmaceutics 1999; 184: 1-6.
11. Chang CC, Yang MH, Wen HM, Chern JC. Estimation of Total Flavonoid Content in Propolis by Two Complementary Colorimetric Methods. Journal of Food and Drug Analysis 2002; 10(3): 178-182.
12. Ropke CD, Kaneko TM, Rodrigues RM, Da Silva VV, Barros S, Sawada TCH, Kato MJ, Barros SBM. Evaluation of percutaneous absorption of 4-nerolidyl cathecol from four topical formulations. International Journal of Pharmaceutics 2002; 249: 109-116.
13. Carvalho Vicentini FTM, Georgetti SR, Badra Bentley MVL, Fonseca MJV. Assessment of in- vitro methodologies to determine topical and transdermal delivery of the flavonoid quercetin. Brazilian Journal of Pharmaceutical Sciences 2009; 45(2): 1335-1342.
14. Saleem MA. Study on in-vitro permeation enhancement of ketoprofen by formation of solid dispersion. International Research Journal of Pharmacy 2011; 2(4): 134-140.
15. Escribano E, Calpena AC, Queralt J, Obach R, Dome´nech J. Assessment of diclofenac permeation with different formulations: anti-inflammatory study of a selected formula. European Journal of Pharmaceutical Sciences 2003; 19: 203-210.
16. Lira AA, Sester EA, Carvalho AL, Strattmann RR, Albuquerque MM, Wanderley AG, Santana DP. Development of Lapachol Topical Formulation: Anti-inflammatory Study of a Selected Formulation. AAPS PharmSciTech. 2008; 9(1): 163-168.
17. Jagtap NS, Khadabadi SS, Farooqui IA, Nalamwar VP, Sawarkar HA. Development and evaluation of herbal wound healing formulations. International Journal of PharmTech Research 2009; 1(4): 1104-1108.
18. Bernatoniene J, Ruta M, Julija D, Rimantas P, Romualda G, Ruta B, Daiva M, Robertas L, Genuvaite C, Saule V, Jan M, Zuzana C. Topical application of Calendula officinalis (L.): Formulation and evaluation of hydrophilic cream with antioxidant activity. Journal of Medicinal Plants Research 2011; 5(6): 868-877.
2. Ogunbiyi, Aruboula EA, Soladoye AO. Analgesic, anti-inflammatory and antipyretic activities from flavonoid fractions of Chromolaena odorata. Journal of Medicinal Plants Research 2008; 2(9): 219-225.
3. Pisutthanan N, Liawruangrath S, Bremner JB, Liawruangrath B. Chemical Constituents and Biological Activities of Chromolaena odorata. Chiang Mai J. Sci. 2005; 32(2): 139-148.
4. Suksamrarn A, Chotipong A, Suavansri T, Boongird S, Timsuksai P, Vimuttipong S, Chuaynugul A. Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata. Arch Pharm Res. 2004; 27(5): 507-511.
5. Taleb-Contini SH, Salvador MJ, Watanabe E, Yoko Ito I, Rodrigues de Oliveira DC. Antimicrobial activity of flavonoids and steroids isolated from two Chromolaena species. Brazilian Journal of Pharmaceutical Sciences. 2003; 39(4): 403-408.
6. Williams AC, Barry BW. Penetration enhancers. Advanced Drug Delivery Reviews 2004; 56: 603-618.
7. Finnin BC, Morgan TM. Transdermal penetration enhancers: Applications, limitations, and potential. Journal of Pharmaceutical Sciences 1999; 88(10): 955.
8. Moser K, Krivet K, Naik A, Kalia YN, Guy RH. Passive skin penetration enhancement and its quantification in vitro. European Journal of Pharmaceutics and Biopharmaceutics 2001; 52: 103-112.
9. Pathan IB, Setty CM. Chemical Penetration Enhancers for Transdermal Drug Delivery Systems. Tropical Journal of Pharmaceutical Research 2009; 8 (2): 173-179.
10. Hadgraft J. Passive enhancement strategies in topical and transdermal drug delivery. International Journal of Pharmaceutics 1999; 184: 1-6.
11. Chang CC, Yang MH, Wen HM, Chern JC. Estimation of Total Flavonoid Content in Propolis by Two Complementary Colorimetric Methods. Journal of Food and Drug Analysis 2002; 10(3): 178-182.
12. Ropke CD, Kaneko TM, Rodrigues RM, Da Silva VV, Barros S, Sawada TCH, Kato MJ, Barros SBM. Evaluation of percutaneous absorption of 4-nerolidyl cathecol from four topical formulations. International Journal of Pharmaceutics 2002; 249: 109-116.
13. Carvalho Vicentini FTM, Georgetti SR, Badra Bentley MVL, Fonseca MJV. Assessment of in- vitro methodologies to determine topical and transdermal delivery of the flavonoid quercetin. Brazilian Journal of Pharmaceutical Sciences 2009; 45(2): 1335-1342.
14. Saleem MA. Study on in-vitro permeation enhancement of ketoprofen by formation of solid dispersion. International Research Journal of Pharmacy 2011; 2(4): 134-140.
15. Escribano E, Calpena AC, Queralt J, Obach R, Dome´nech J. Assessment of diclofenac permeation with different formulations: anti-inflammatory study of a selected formula. European Journal of Pharmaceutical Sciences 2003; 19: 203-210.
16. Lira AA, Sester EA, Carvalho AL, Strattmann RR, Albuquerque MM, Wanderley AG, Santana DP. Development of Lapachol Topical Formulation: Anti-inflammatory Study of a Selected Formulation. AAPS PharmSciTech. 2008; 9(1): 163-168.
17. Jagtap NS, Khadabadi SS, Farooqui IA, Nalamwar VP, Sawarkar HA. Development and evaluation of herbal wound healing formulations. International Journal of PharmTech Research 2009; 1(4): 1104-1108.
18. Bernatoniene J, Ruta M, Julija D, Rimantas P, Romualda G, Ruta B, Daiva M, Robertas L, Genuvaite C, Saule V, Jan M, Zuzana C. Topical application of Calendula officinalis (L.): Formulation and evaluation of hydrophilic cream with antioxidant activity. Journal of Medicinal Plants Research 2011; 5(6): 868-877.
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01-04-2012
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“ASSESSMENT OF FLAVONOID RELEASE WITH DIFFERENT PERMEATION ENHANCERS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 2, Apr. 2012, pp. 154-6, https://doi.org/10.25004/IJPSDR.2012.040215.
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Copyright (c) 2012 M. N. Vaisakh, A. Pandey
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“ASSESSMENT OF FLAVONOID RELEASE WITH DIFFERENT PERMEATION ENHANCERS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 2, Apr. 2012, pp. 154-6, https://doi.org/10.25004/IJPSDR.2012.040215.
