EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF TAMARINDUS INDICA SEEDS
Abstract
In this study, we investigated the effects of methanolic extract of Tamarindus indica (TI) seeds on anti-inflammatory and analgesic activities in vivo using rat as an animal model at the doses of 100 mg/kg, 200 mg/kg and 400 mg/kg body weight. The anti-inflammatory activities were investigated by utilizing carrageenan induced paw edema in rat. The analgesic activity was examined against tail immersion method in rats. The results showed that TI significantly (p<0.01) reduced carrageenan induced paw edema in rats. In tail immersion method, methanolic extract of Tamarindus indica has shown significant (p<0.01) increase in reaction time of tail in water maintained at 55°C indicating analgesic activity. Preliminary phytochemical screening of the extract revealed the presence of alkaloids, tannins, saponins, glycosides and flavonoids. These results demonstrated that the methanolic extract of Tamarindus indica (TI) seed exhibited significant analgesic and anti-inflammatory activities.
Keywords:
Analgesic, Anti-inflammatory, Tamarindus indica, CarrageenanDOI
https://doi.org/10.25004/IJPSDR.2012.040309References
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14. Winter CA, Risley EA, Nuss GW. Carrageenan-induced edema in hind paws of the rat as assay for anti-inflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine 1962; 11: 544-547.
15. William JK. Arthritis and allied condition - a textbook of rheumatology. Edi 13, A Waverly Company, Baltimore, Tokyo, 1996, 1, pp. 133-198.
16. Eddy ND, Leimback D. Synthetic analgesics. II. Dithyienylbutenyl-amines and dithyienylbutylamines. Journal of Pharmacology and Experimental Therapeutics. 1953; (3): 544-547.
17. Vaz ZR, Mata LV, Calixt JB. Analgesic effect of the herbal medicine catuama in thermal and chemical models of nociception in mice. Phytotherapy Research 1997; 11:101-106.
18. Rujjanawate C, Kanjanapothi D, Panthong A. Pharmacological effect and toxicity of alkaloids from Gelsemium elegans Benth. Journal of Ethnopharmacology 2003; 89: 91–95.
19. Asongalem EA, Foyet HS, Kamtchouing P. Anti-inflammatory lack of central analgesia and antipyretic properties of Acanthus montanus (Ness) T. Anderson. Journal of Ethnopharmacology 2004; 95:63-68.
2. Kalra B, Chaturvedi S, Tayal V. Evaluation of gastric tolerability, antinoceptive and anti-inflammatory activity of combination NSAIDs in rats. PubMed 2010; 7:210-212.
3. Nadkarni AK, Nadkarni KM (Eds.). Indian Materia Medica. 3rd ed., Popular Prakashan Pvt. Ltd., Mumbai, 1976, I, pp. 1191.
4. Pankaj K, Sunil S, Suresh K. Antiulcer effect of methanolic extract of Tamarindus indica seeds in different experimental models. Journal of Pharmacy and Bioallied Science 2011; 3: 236-241.
5. Nurhanani R, Amirah F, Senthilkumar S. Effects of various solvents on the extraction of antioxidant phenolics from the leaves, seeds, veins and skins of Tamarindus indica L. Food Chemistry 2012; 132: 441-448
6. Boots AW, Haenen GR, Bast A. Health effects of quercetin: From antioxidant to nutraceutical. European Journal of Pharmacology 2008; 585: 325-337.
7. Valko M, Rhodes CJ, Moncol J. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-Biological Interactions 2006; 160: 1-40.
8. Doughari JH. Antimicrobial activity of Tamarandus indica Linn. Tropical Journal of Pharmaceutical Research 2006; 5: 597-603.
9. OECD Guideline For The Testing of Chemicals: Acute oral toxicity-Acute Toxic Class Method. 2001; 423.
10. Bhalerao A, Desai S, Serathia B. Acute and Subacute Models of Inflammation of Nyctanthes arbor tristis and Maharasnadi Ghan. International Journal of Pharmacology Research 2011; 1: 14-24.
11. Mohemad TS, Darba BS, Mahesh G. Analgesic, Antipyretic & Anti-inflammatory activity of dietary seasome oil in Experimental Animal Models, Pharmacologia 2011; 2: 172-177.
12. O’Byrne KJ, Dalgleish AG. Chronic immune activation and inflammation as the cause of malignancy. Br. J. Cancer 2001; 85: 473-483.
13. O’Byrne KJ, Dalgleish AG, Browning MJ. The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease. Eur. J. Cancer 2000; 36: 151-169.
14. Winter CA, Risley EA, Nuss GW. Carrageenan-induced edema in hind paws of the rat as assay for anti-inflammatory drugs. Proceedings of the Society for Experimental Biology and Medicine 1962; 11: 544-547.
15. William JK. Arthritis and allied condition - a textbook of rheumatology. Edi 13, A Waverly Company, Baltimore, Tokyo, 1996, 1, pp. 133-198.
16. Eddy ND, Leimback D. Synthetic analgesics. II. Dithyienylbutenyl-amines and dithyienylbutylamines. Journal of Pharmacology and Experimental Therapeutics. 1953; (3): 544-547.
17. Vaz ZR, Mata LV, Calixt JB. Analgesic effect of the herbal medicine catuama in thermal and chemical models of nociception in mice. Phytotherapy Research 1997; 11:101-106.
18. Rujjanawate C, Kanjanapothi D, Panthong A. Pharmacological effect and toxicity of alkaloids from Gelsemium elegans Benth. Journal of Ethnopharmacology 2003; 89: 91–95.
19. Asongalem EA, Foyet HS, Kamtchouing P. Anti-inflammatory lack of central analgesia and antipyretic properties of Acanthus montanus (Ness) T. Anderson. Journal of Ethnopharmacology 2004; 95:63-68.
Published
01-07-2012
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“EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF TAMARINDUS INDICA SEEDS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 3, July 2012, pp. 213-7, https://doi.org/10.25004/IJPSDR.2012.040309.
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How to Cite
“EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF TAMARINDUS INDICA SEEDS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 4, no. 3, July 2012, pp. 213-7, https://doi.org/10.25004/IJPSDR.2012.040309.
