HYPOGLYCEMIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF CALYCOPTERIS FLORIBUNDA INDUCED BY STREPTOZOTOCIN IN RATS
Abstract
The present investigation was carried out to study the hypoglycemic effects of the hydro-alcoholic (70:30) extract of Calycopteris floribunda, in normal and streptozotocin induced diabetic model. Calycopteris floribunda, are reported to have medicinal and traditional values including hypoglycemic properties. Decreased blood glucose level of the test animals shows that the extract exhibit significant hypoglycemic activity when compared to diabetic control group, effect of various doses (100, 200 mg/kg, p.o) extract was studied on streptozotocin induced both diabetic and non diabetic rats. The results also indicated the dose dependent effect. The hypoglycemic activity produced by the extract may be due to increased uptake of glucose at the tissue level or by an increase in pancreatic beta cell function or due to inhibition of intestinal absorption of glucose. The present study supports the use of this herbal drug as hypoglycemic. The reduction in the glucose level in induced diabetic rats proved that Calycopteris floribunda having the hypoglycemic activity.
Keywords:
Calycopteris floribunda, Streptozocin, hypoglycemic, diabetesDOI
https://doi.org/10.25004/IJPSDR.2012.040406References
2. Kameswara Rao B, Renuka Sudarshan P, Rajasekhar MD, Nagaraju N, Appa Rao Ch. Antidiabetic activity of Terminalia pallida fruit in alloxan-induced diabetic rats. J Ethnopharmacol. 2003; 85: 169-172.
3. Burcelin R, Eddouks M, Maury J, Kande J, Assan R, Girard J. Excessive glucose production, rather than insulin resistance, accounts for hyperglycemia in recent-onset streptozotocin-diabetic rats. Diabetologia 1995; 38: 283-290
4. Kamesawara BR, Giri R, Kesavulu MM, Apparao CH. Effect of oral administration of bark extracts of Pterocarpus santalinus L. on blood glucose level in experimental animals. J Ethnopharmacol. 2000; 74: 69–74.
5. Yoshida K, Hirokawa J, Tagami S. Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux. Diabetologia 1995; 38: 201-210.
6. Paolisso G, Di Maro G, Pizza. Plasma GSH/GSSG affects glucose homeostasis in healthy subjects an NIDDM. Am J Physiol. 1992; 263: E435-440.
7. Jacot E, Assal JPH. Regulation de la glycemie. Dans: Pharmacologic des concepts Fondamentaux aux Applications Therapeutiques. Schorderet, in: Frison-Rocheet Slatkine (Ed.), 1989; 481-494.
8. Junod A, Lambert AE, Stauffacher W, Renold AE. Diabetogenic action of streptozotocin of dose to metabolic response. J of Clini Inves. 1969; 48: 2129-2139.
9. Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine 1995; 22:123-189.
10. Ali L, Azad Khan AK, Mamun MIR, Mosihuzzaman M, Nahar N, Nur-E-Alan M, Rokeya B. Studies on the hypoglycemic effects of fruits pulp, seed and whole plant of Momordica charantia on normal and diabetic model rats. Planta Medica 1993; 59: 408-412.
11. Thalla S, Pentela B. Hepatoprotective effect of hydroalcoholic extract of Calycopteris floribunda leaves on Rifampicin-Isoniazid induced rats. Int J C Pharm Sci. 2011; 2(3): 15-21.
12. Thalla S, Pentela B. Antidiabetic activity of hydroalcoholic extract of Asteracantha longifolia induced by streptozocin in rats. Int J C Pharm Sci. 2012; 3(1): 46-49.
13. Jayakar B, Suresh B. Antihyperglycemic and hypoglycemic effect of Aporosa lindleyana in normal and alloxan induced diabetic rats, J Ethnopharmacol. 2002; 84: 247-49.
Published
Abstract Display: 312 
PDF Downloads: 402 
