NEPHROPROTECTIVE EFFECTS OF METHANOLIC EXTRACT OF PEUCEDANUM GRANDE AGAINST ACUTE RENAL FAILURE INDUCED BY POTASSIUM DICHROMATE IN RATS
Abstract
Peucedanum grande has been found to be associated with the several therapeutic properties. In the current study, we have used P. grande as an ameliorating agent against nephrotoxic effects of Potassium dichromate. Potassium dichromate (K2Cr2O7) is a soluble hexavalent chromium compound that is extensively used in several industries. The rats were given pretreatment of P. grande orally at a dose of (60 and 120 mg/kg body weight) for five consecutive days 10 mg/kg b.wt was used as renal toxicant, and injected subcutaneously in the neck region in a volume of 1 ml/kg. The modulatory effects of P. grande on Potassium dichromate induced nephrotoxicity was investigated by assaying oxidative stress biomarkers, lipid peroxidation, serum kidney toxicity markers and by histopathological examination of kidney. P. grande pretreatment prevented deteriorative effects induced by Potassium dichromate through a protective mechanism that involved reduction of increased oxidative stress as well as by restoration of histopathological change against Potassium dichromate administration.
Keywords:
Peucedanum grande, Mercuric chloride, Kidney, histopathology, oxidative stressDOI
https://doi.org/10.25004/IJPSDR.2013.050202References
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30. O´ Brien, P, Kortenkamp A. Chemical models important in understanding the ways in which chromate can damage DNA. Environ. Health Perspect. 1994; 102: 3-10.
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32. Barrera D, Maldonado PD, Medina-Campos ON, Hernandez-Pando R, Ibarra-Rubio ME, Pedraza-Chaverri J. Protective effect of SnCl2 on K2Cr2O7-induced nephrotoxicity in rats: the indispensability of HO-1 preinduction and lack of association with some antioxidant enzymes. Life Sciences 2003; 73(23):3027-3041
33. Appenroth D, Winnefeld K. Vitamin E and C in the prevention of metal nephrotoxicity in developing rats. Exp. Toxicol. Pathol. 1998; 50:391-396.
34. Arreola-Mendoza L, Reyes JL, Melendez E, Martin D, Namorado MC, Sa´nchez E, Del Razo LM. Alpha-tocopherol protects against the renal damage caused by potassium dichromate. Toxicology 2006; 218: 237–246.
35. Zunino F. Protective effect of reduced glutathione against cisplatin-induced renal and systemic toxicity and its influence on the therapeutic activity of the antitumor drug. Chem-Biol Interact 1989; 70 (1-2): 89-101.
2. Jennette KW. The role of metals in carcinogenesis: biochemistry and metabolism. Environ Health Perspect 1981; 40:233-252.
3. Lu YY, Yang JL. Long term exposure to chromium(VI) oxide leads to defects in sulfate transport system in Chinese hamster ovary cells. J Cell Biochem 1995; 57:655-665.
4. Pellerin C, Booker SM. Re X ections on hexavalent chromium: health hazards of an industrial heavyweight. Environ Health Perspect 2000; 108:A402-A407.
5. Standevan AM, Wetterhahn KE. Ascorbate is the principal reductant of chromium (VI) in rat liver and kidney ultra W ltrates. Carcinogenesis 1991; 12:1733-1739.
6. Liu KJ, Shi X. In-vivo reduction of chromium (VI) and its related free radical generation. Mol Cell Biochem 2001; 222:41-47.
7. Shi XG, Chiu A, Chen CT, Halliwell B, Castranova V, Vallyathan V. Reduction of chromium (VI) and its relationship to carcinogenesis. J Toxicol Environ Health 1999; 2:87-104.
8. Sugiyama M. Role of paramagnetic chromium in chromium (VI)-induced damage in cultured mammalian cells. Environ Health Perspect 1994; 102:31-33.
9. Kirtikar K, Basu BD. Indian Medicinal Plants. Rajpur Road, Dehradun India, International Book Distributors, 1987.
10. Ghani N. Khazainul Advia. Urdu Bazar Lahore, Sheikh Md. Basheer and Sons, 1911.
11. Sina I. Al Qanoon fit Tib. (Urdu translation) Lahore, Pakistan, Nigare Ashayat Main Chambar, 1920.
12. Sina I. Alqanoon. (Urdu Translation). Lahore, Sheikh Md. Basheer and sons, 1927.
13. Rushad I. Kitabul Kulyat. New Delhi, CCRUM, 1980.
14. Khan N, Sultana S. Chemomodulatory effect of Ficus racemosa extract against chemically induced renal carcinogenesis and oxidative damage response in Wistar rats. Life sciences 2005; 77: 1194-1210.
15. MW K. Clinical Chemistry. The Bobber Merrill Company Inc., USA, 1975
16. Hare RS. Endogenous creatinine in serum and urine. Proc. Soc. Exp. Biol. Med, 1950;74: 148.
17. Wright JR, Colby HD, Miles PR. Cytosolic factors which affect microsomal lipid peroxidation in lung and liver. Archives of Biochemistry and Biophysics 1981; 206: 296-304.
18. Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974; 11: 151-169.
19. Stevens MJ, Obrosova I, Cao X. Effects of DL-alpha- lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy. Diabetes. 2000; 49: 1006-15.
20. Claiborne A Catalase activity. Handbook of methods for oxygen radical research, CRC. 1985; 283-284.
21. Barceloux, DG. Chromium. Clin. Toxicol. 1999; 37:173-194.
22. Wang XF, Xing ML, Shen Y, Zhu X, Xu, LH. Oral administration of Cr(VI) induced oxidative stress, DNA damage and apoptotic cell death in mice. Toxicology 2006; 228: 16-23.
23. Stohs SJ, Bagchi D, Hassoun E, Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J. Environ. Pathol. Toxicol. Oncol. 2000; 19: 201-213.
24. Norseth T. The carcinogenicity of chromium. Environ. Health Perspect. 1981; 40: 121-130.
25. Bagchi D, Stohs S, Downs B, Bagchi M, Preuss HG. Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology 2002; 180, 5-22.
26. Pedraza-Chaverri, J, Barrera D, Medina-Campos, ON, Carvajal RC, Hernandez-Pando R, Macias-Ruvalcaba, NA. Time course study of oxidative and nitrosative stress and antioxidant enzymes in K2Cr2O7-induced nephrotoxicity. BMC Nephrol. 2005; 26: 4.
27. Franchini I, Mutti A, Cavatorta A, Corradi A, Cosi A, Olivetti G, Borghetti A. Nephrotoxicity of chromium. Remarks on an experimental and epidemiological investigation. Contrib. Nephrol. 1978; 10: 98-110.
28. Huang YL, Chen CY, Sheu JY, Chuang IC, Pan JH, Lin TH. Lipid peroxidation in workers exposed to hexavalent chromium. J. Toxicol. Environ. Health A. 1999; 26:235-247.
29. Sengupta T, Chattopadhyay D, Ghosh N, Maulik G, Chatterjee GC. Impact of chromium on lipoperoxidative processes and subsequent operation of the glutathione cycle in rat renal system. Indian J. Biochem. Biophys. 1992; 29:287-290.
30. O´ Brien, P, Kortenkamp A. Chemical models important in understanding the ways in which chromate can damage DNA. Environ. Health Perspect. 1994; 102: 3-10.
31. Aiyar J, Berkovits, HJ, Floyd RA, Wetterhahn KE. Reaction of chromium(VI) with glutathione or with hydrogen peroxide: identification of reactive intermediates and their role in chromium(VI)- induced DNA damage. Environ. Health Perspect. 1991; 92: 53-62.
32. Barrera D, Maldonado PD, Medina-Campos ON, Hernandez-Pando R, Ibarra-Rubio ME, Pedraza-Chaverri J. Protective effect of SnCl2 on K2Cr2O7-induced nephrotoxicity in rats: the indispensability of HO-1 preinduction and lack of association with some antioxidant enzymes. Life Sciences 2003; 73(23):3027-3041
33. Appenroth D, Winnefeld K. Vitamin E and C in the prevention of metal nephrotoxicity in developing rats. Exp. Toxicol. Pathol. 1998; 50:391-396.
34. Arreola-Mendoza L, Reyes JL, Melendez E, Martin D, Namorado MC, Sa´nchez E, Del Razo LM. Alpha-tocopherol protects against the renal damage caused by potassium dichromate. Toxicology 2006; 218: 237–246.
35. Zunino F. Protective effect of reduced glutathione against cisplatin-induced renal and systemic toxicity and its influence on the therapeutic activity of the antitumor drug. Chem-Biol Interact 1989; 70 (1-2): 89-101.
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01-04-2013
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“NEPHROPROTECTIVE EFFECTS OF METHANOLIC EXTRACT OF PEUCEDANUM GRANDE AGAINST ACUTE RENAL FAILURE INDUCED BY POTASSIUM DICHROMATE IN RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 5, no. 2, Apr. 2013, pp. 45-49, https://doi.org/10.25004/IJPSDR.2013.050202.
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How to Cite
“NEPHROPROTECTIVE EFFECTS OF METHANOLIC EXTRACT OF PEUCEDANUM GRANDE AGAINST ACUTE RENAL FAILURE INDUCED BY POTASSIUM DICHROMATE IN RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 5, no. 2, Apr. 2013, pp. 45-49, https://doi.org/10.25004/IJPSDR.2013.050202.
