IN-VITRO ANTIOXIDANT ACTIVITY AND GC/MS STUDIES ON THE LEAVES OF MENTHA PIPERITA (LAMIACEAE) FROM MOROCCO
Abstract
The present study was to evaluate the in vitro antioxidant activity and chemical composition of essential oil of Mentha piperita from Morocco. Mentha species from the Lamiaceae family are widely distributed in Morocco and commonly used as herbal tea, flavoring agent and medicinal plant. In this stud y, the essential oils of Mentha piperita collected in the region of Meknes (Morocco) were obtained by hydro-distillation of the leaves and analysed by gas chromatography equipped with flame ionisation detector (GC-FID) and gas chromatography coupled to mass spectrometry system (GC/MS) for their chemical composition. The antioxidant activity of essential oils against DPPH radical was determined in vitro by treated with different concentrations of essential oil and vitamin C as standard antioxidant compound. The percentages of DPPH inhibition and IC50 were recorded. Thirty compounds were identified in leaves oil representing 58.61% of the total oil composition. The yield of essential oil of Mentha piperita was 1.02% and the major compound in the leaves was: Menthone (29.01%) followed by menthol (5.58%), menthyl acetate (3.34%), menthofuran (3.01%), 1,8-cineole (2.40%), isomenthone (2.12%), limonene (2.10%), α-pinene (1.56%), germacrene-D (1.50%), β-pinene (1.25%), sabinene (1.13%) and pulegone (1.12%). The radical scavenging activity (% inhibition) of the essential oil from Mentha piperita was the highest (81.09± 1.21%) at the concentration of 150µg/ml and the IC50 values of these plant extracts were 53.67µg/ml.
Keywords:
Mentha piperita, GC/MS, Antioxidant activity, Menthone.DOI
https://doi.org/10.25004/IJPSDR.2011.030212References
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2. Verma R, Rahman L, Verma R, Chauhan A, Yadav, Singh A. Essential Oil Composition of Menthol Mint (Mentha arvensis) and Peppermint (Mentha piperita) Cultivars at Different Stages of Plant Growth from Kumaon Region of Western Himalaya. Journal of Medicinal and Aromatic Plants. 2010; 1(1): 13-18.
3. Kofidis G, Bosabalidis A, Kokkini S. Seasonal variation of essential oils in a linalool rich chemotype of Mentha spicata grown wild in Greece. J. Essent. Oil .Res. 2004; 16: 469-472.
4. Drazic S, Pavlovic S. Effects of vegetation space in productive traits of peppermint (Mentha piperita L). Institute for medicinal plantd research Dr Josif pancic, Tadeusa koskusa1, 1100 Belgrade, FR Yugoslavia 2005.
5. Nostro N, Germano M, Ángelo V, Cannatelli M. Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity. Lett. Appl. Microbiol. 2000; 30: 379-384.
6. Pierangeli G, Vital G, Windell R. Antimicrobial activity and cytotoxicity of Chromolaena odorata (L. f). King and Robinson and Uncaria perrottetii (A. Rich) Merr. Extracts. J. Medicinal Plants Res. 2009; 3(7): 511-518.
7. Ormancey X, Sisalli S, Coutiere P. Formulation of essential oils in functional perfumery. Parfums, Cosmetiques, Actualites. 2009; 157: 30-40.
8. Buchbauer G. The detailed analysis of essential oils leads to the understanding of their properties. Perfumer & Flavorist. 2000; 25: 64-67.
9. Dudareva N, Negre F, Nagegowda D, Orlova I. Plant volatiles: Recent advances and future perspectives. Crit. Rev. Plant Sci. 2006; 25: 417-40.
10. Iscan G, Demirci F, Kirimer N, Ku¨rkcu¨oglu M, Baser K. Antimicrobial screening: Mentha piperita essential oil. J. Agric Food Chem. 2002; 50: 3943-3946.
11. Sokovic M, Vukojević J, Petar D, Dejan D, Vlatka V, Leo J. Chemical composition of essential oils of Thymus and Mentha species and their antifungal activities. Molecules. 2009; (1):238-249.
12. Behnam S, Farzaneh M, Ahmadzadeh M, Tehrani A. Composition and antifungal activity of essential oils of Mentha piperita and Lavendula angustifolia on post-harvest phytopathogens. Commun Agric Appl Biol Sci. 2006; 71(3):1321-6.
13. Eteghad S, Mirzaei H, Pour S, Kahnamui S. Inhibitory Effects of Endemic Thymus vulgaris and Mentha piperita Essential oils on Escherichia coli O157: H7. Res .J. Biol. Sc. 2009; 4(3): 340-344
14. Kanatt S, Chander R, Sharma A. Chilean and mint mixture: A new preservative for meat and meat products. Food Chem. 2008; 107: 845-852.
15. Marino M, Borsani C, Comi G. Impedance measurements to study the antimicrobial activity of essential oils from Lamiaceae. Int. J. Food Microbiol. 2001; 67: 187-195.
16. Pandey A, Rai M, Acharya D. Chemical Composition and Antimycotic Activity of the Essential Oils of Corn Mint (Mentha arvensis) and Lemon Grass (Cymbopogon flexuosus) Against Human Pathogenic Fungi. Pharmaceutical Biology. 2003; 41(6): 421-425.
17. Seun-Ah Y, Sang-Kyung J, Eun-Jung L, Chang-Hyun S, In-Seon L. Comparative study of the chemical composition and antioxidant activity of six essential oils and their components. Nat. Prod. Res. 2010; 24 (2): 140-151.
18. Baris O, Gulluce M, Shain F, Ozer H, Kilic H, Ozkan H, Sokmen M, Ozber T. Biological activities of the essential oil and methanol extract of Achillea biebersteinii (Asteraceae). Turk. J. Biol. 2006; 30: 65-73.
19. Palevitch D. Non-conventional uses of volatile oils and their constituents in Agriculture in: Proceedings of the 4th symposium on the economy of medicinal and aromatic plants. Nyons; 1991: 26-40.
20. Uphof J. Dictionary of Economic Plants, p 290. Verlag von Cramer, Germany 1968.
21. Zoran Z, Zika L, Slavica M, Dušan A, Ibrahim M. Supercritical CO2 extraction of mentha (Mentha piperita L.) at different solvent densities. J. Serb. Chem. Soc. 2009; 74 (4): 417–425
22. Zargari A. Medicinal Plants. Vol. 4. Tehran University Publications, Tehran.1990; 4-20
23. Amin G. Popular Medicinal Plants of Iran. Vice-chancellorship of Research, Tehran University of Medical Sciences, Tehran.2005: 92-93.
24. Adams R. Identification of Essential Oil Components by Gas Chromatography/ Mass Spectrometry. Quadrupole. Allured Publ. Corp., Carol Stream, IL 2001.
25. Pokorny L. Antioxidants in food preservation. In Handbook of Food Preservation. Shafiur Rahman M (Ed). Marcel Dekker, New York. 1999; 309-337.
26. Takahashi M, Furukawa F, Toyoda K, Sato H, Hasegawa R, Hayashi Y. Effects of four antioxidants on N-methyl-N-nitrosoguanidine initiated gastric tumor development in rats. Cancer Letters, 1986; 30: 161-168.
27. Offord E, Mace K, Ruffieux C, Malnoe A, Pfeifer A. Rosemary components inhibit benzopyrene-induced genotoxicity in human bronchial cells. Carcinogenesis. 1995; 16: 2057-2062.
28. Ramy M, Sayed A, Mahmoud I. Chemical composition, Antivirus and antioxidant Activities of Seven Essential Oils. Journal of Applied Sciences Research. 2010; 6: 50-62.
29. Albayrak S, Aksoy A, Sagdic O, Hamzaoglu M. Compositions, antioxidant and antimicrobial activities of Helichrysum (Asteraceae) species collected from Turky. Food Chemistry. 2010; 119: 114-122.
30. Derwich E, Benziane Z, Boukir A. Chemical Composition and Insecticidal Activity of Essential Oils of three Plants Artemisia sp: Artemisia herba-alba, Artemisia absinthium and Artemisia pontica (Morocco). EJEAFChe. 2009; 8 (11): 1202-1211.
31. Imelouane B, Amhamdi H, Wathelet J, Ankit M, Khedid K, El Bachiri A. Chemical composition of the essential oil of thyme (Thymus vulgaris) from Eastern Morocco. Int. J. Agric. Bio. 2009; 11: 205-208.
32. Edward P, Claus E, Varro, Lynn R. Pharmacognosy, sixth edition LEA and Febiger (ed). 1987; 18: 184-187.
33. Akrout A, Chemli R, Chreif I, Hammami M. Analysis of the essential oil of Artemisia campestris L. Flav Fragr. J. 2001; 16: 337-339.
34. Bourkhiss M, Hnach M, Bourkhiss B, Ouhssine M, Chaouch A. Composition chimique et propriétés antimicrobiennes de l’huile essentielle extraite des feuilles de Tetraclinis articulata (Vahl) du Maroc. Afri. Sci. 2000; 3(2): 232-242.
35. Reza Monsef-Esfahani H, Amanzade Y, Alhani Z, Hajimehdipour H, Faramarzi M. GC/MS Analysis of Citrus aurantium L. Hydrolate and its Comparison with the Commercial Samples. Iranian Journal of Pharmaceutical Research. 2004; 3: 177-179.
36. Ghannadi A, Aghazari F, Mehrabani M, Mohagheghzadeh A, Mehregan I. Quantity and Composition of the SDE Prepared Essential Oil of Nepeta macrosiphon Boiss. Iranian Journal of Pharmaceutical Research. 2003: 103-105.
37. Derwich E, Benziane Z, Boukir A. Chemical Composition and Antibacterial Activity of Leaves Essential Oil of Laurus nobilis from Morocco. Aust. J. Basic & Appl. Sci. 2009; 3(4): 3818-3824.
38. Derwich E, Benziane Z, Boukir A. Chemical composition of leaf essential oil of Juniperus phoenicea and evaluation of its antibacterial activity. Int. J. Agric. Biol. 2010; 12 (2): 199-204.
39. Aridogan B, Baydar H, Kaya S, Demirci M, Ozbasar B, Mumcu M. Antibacterial activity and chemical composition of some essential oils. Arch Pharm Res. 2002; 25 (6): 860- 864.
40. Ashok K, Chandra S, Dutt P, Lal Kaul B, Tava A, Avato P. Essential oil composition of Mentha x piperita L. from different environments of north India. Flav Fragr. J. 1999; 14 (1): 5-8.
41. Arldogan B, Bayda H, Kaya Demirci S, Ozbaw D, Mumcu E. Antimicrobial Activity and Chemical Composition of Some Essential Oils. Arch Pharm Res. 2002; 25 (6): 860-864.
42. Yadegarinia D, Gachkar L, Bagher Rezaei M, aghizadeh M, Alipoor S, Rasooli I. Biochemical activities of Iranian Mentha piperita L. and Myrtus communis L. essential oils. Phytochem. 2006; 67: 1249-1255.
43. Carla D, Decorti D. Ultrasound-assisted extraction coupled with under vacuum distillation of .favour compounds from spearmint (carvone-rich) plants: Comparison with conventional hydrodistillation. Ultrasonics Sonochemistry. 2009; 16: 795-799.
44. Chalchat J, Garry R, Michet A. Variation of the chemical composition of essential oil of (Mentha piperita L) during the growthing time. J. Essential Oil Res. 1997; 9: 463-465.
45. Hefendehl F, Merrit J, Murray M. Monoterpene composition of chemotype of Mentha piperita having high limonene. Planta Med. 1973); 23: 101-106.
46. Lawrence B. Progress in essential oils. Perfumer-and- Flavorist. 1998; 23: 63-68.
47. Pino J, Rosado A, Fuentes V. Chemical composition of the essential oil of Mentha pulegium L. from Cuba. J. Essent. Oil Res. 1996; 8: 295-296.
48. Mimica-Dukic N, Bozin B, Sokovic M, Mihajlovic B, Matavulj M. Antimicrobial and antioxidant activities of three Mentha species essential oils. Planta Med. 2003; 69 (5), 413-419.
49. Aflatuni A. The yield and essential oil content of mint (menthe spp) in Northern Ostrobothnia. Academic dissertation to be presented with the assent of the faculty of science. University of Oulou. 2005.
50. Piccaglia R, Delacecca V, Marotti M, Giovanelli E. Agronomic factors affecting the yields and essential oil composition of peppermint (Mentha pulegium L). ISHS Acta Horticulturae, International Symposium on Medicinal and Aromatic plants. UK. 2005.
51. Robert P, Barrero A, Lara A. Comparisons of the Leaf Essential Oils of Juniperus phoenicea. J. Essent. Oil Res. 1996; 8: 367- 371.
52. Abbaszadeh B, Valadabadi S, Farahani H, Darvishi H. Studying of essential oil variations in leaves of Mentha species. Africa. J. Plant Sc. 2009; 3 (10): 217-221
53. Jean-Claude C, Ozcan M. Comparative essential oil composition of flowers, leaves and stems of basil (Ocimum basilicum L.) used as herb. Food Chem. 2008; 110: 501-503.
54. Daniel L, Dellacassa D, Davies P, Villa R, Canigueral S. Essential oils of Mentha pulegium and Mentha rotundifolia From Uruguay, Braz. Arch. Biol & Tech. 2002; 45: 519-524
55. Mclafferty F, Stauffer D. The Important Peak Index of the Registry of Mass Spectral Data, Wiley, New York. 1991; Vol. 1.
56. Samarth R, Meenakshi P, Manish K, Anil S, Madhu K, Ashok K. Evaluation of antioxidant and radical-scavenging activities of certain radioprotective plant extracts. Food Chemistry. 2008; 106: 868-873.
57. Souri E, Gholamreza A, Dehmobed-Sharifabadi A, Atefeh N and Farsam H. Antioxidative Activity of Sixty Plants from Iran. Iranian Journal of Pharmaceutical Research. 2004; 23: 55-59.
58. Nickavar B, Alinaghi A, Kamalinejad M. Evaluation of the Antioxidant Properties of Five Mentha Species. Iranian Journal of Pharmaceutical Research. 2009; 7 (3): 203-209
59. Souri E, Gholamreza A, Farsam H, Jalalizadeh H, Barezi S. Screening of Thirteen Medicinal Plant Extracts for Antioxidant, Iranian Journal of Pharmaceutical Research, 2008; 7 (2): 149-154
60. Yadegarinia D, Gachkar L, Bagher Rezaei M, Taghizadeh M, Alipoor Astaneh S, Rasooli I. Biochemical activities of Iranian Mentha piperita L. and Myrtus communis L. essential oils, Phytochemistry 2006; 67:1249-1255.
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01-04-2011
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“IN-VITRO ANTIOXIDANT ACTIVITY AND GC MS STUDIES ON THE LEAVES OF MENTHA PIPERITA (LAMIACEAE) FROM MOROCCO”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 2, Apr. 2011, pp. 130-6, https://doi.org/10.25004/IJPSDR.2011.030212.
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Copyright (c) 2011 Elhoussine derwich, Rachida Chabir, Rachid Taouil, Omar Senhaji
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“IN-VITRO ANTIOXIDANT ACTIVITY AND GC MS STUDIES ON THE LEAVES OF MENTHA PIPERITA (LAMIACEAE) FROM MOROCCO”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 2, Apr. 2011, pp. 130-6, https://doi.org/10.25004/IJPSDR.2011.030212.
