FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF GLIBENCLAMIDE
Abstract
Matrix type transdermal patches containing Glibenclamide were prepared using three different polymers by solvent evaporation technique. Aluminium foil cup method was used as a substrate. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide (DMSO) was used as penetration enhancer. The physicochemical parameters like weight variation, thickness, folding endurance, drug content, % moisture absorption and % moisture loss were evaluated. In vitro drug release studies and skin permeation studies were carried out using Franz diffusion cell. Cumulative amount of drug released in 12 hours from the six formulations were 55.467, 52.633, 47.157, 53.394, 49.139 and 45.597 %, respectively. The corresponding values for cumulative amount of drug permeated for the said formulation were 43.013, 40.429, 37.793, 41.522, 37.450 and 34.656 %, respectively. On the basis of in vitro drug release and skin permeation performance, formulation HP-1 was found to be better than other formulations and it was selected as the optimized formulation.
Keywords:
Glibenclamide, In vitro drug release, Matrix type transdermal drug delivery systemsDOI
https://doi.org/10.25004/IJPSDR.2009.010111References
2. Shaw JE, Chandrasekaran SK and Campbell P. Percutaneous absorption: Controlled drug delivery for topical or systemic therapy. J. Invest. Dermatol. 1976; 67: 677.
3. Costa P, Farreira DC, Morgado R and Lobo JMS. Design and evaluation of lorazepam transdermal delivery system. Drug. Dev. Ind. Pharm. 1997; 23: 939- 44.
4. Guy RH, Hadgraft J, Bucks DAW. Transdermal drug delivery and cutaneous metabolism. Xenobiotica. 1987; 17: 325.
5. www.drugbank.com
6. Tripathi KD. Essential of Medical Pharmacology, Edn 4, Jaypee Brothers Medical Publishers, 2004, pp. 278.
7. Aqil M, Sultana Y, Ali A. Matrix type transdermal drug delivery systems of metoprolol tartrate: Characterization. Acta Pharma. 2003; 53: 119-25.
8. Satturwar PM, Fulzele SV, Dorle AK. Evaluation of polymerized Rosin for the formulation and development of transdermal drug delivery system: A technical note. AAPS Pharma Sci. Tech. 2005; 6(4): E649-54.
9. Devi VK, Saisivam S, Maria GR, Deepti PU. Design and Evaluation of Matrix Diffusion Controlled Transdermal Patches of Verapamil Hydrochloride. Drug Development and Industrial Pharmacy.2003; 29(5): 495-503.
10. Mutalik S, Udupa N. Glibenclamide Transdermal Patches: Physicochemical, Pharmacodynamic and Pharmacokinetic Evaluation. Journal of Pharmaceutical Sciences. 2004; 93:1577-94.
11. Franz T. Percutaneous absorption: on the relevance of in vitro data. J. Invest. Dermatol. 1975; 64: 190-95.
12. Ali A, Rada S, Agrawal SP. Fabrication of diffusion cell for the determination of drug released from topical aerosol formulations. Indian Drugs. 1997; 34: 715-17.
13. Arora A, Mukherjee B. Design development, physicochemical and in vitro and in vivo evaluation of transdermal patches containing diethyl/ammonium salt. J. Pharm Sci. 2002; 91: 2076-89.
14. Sood A, Panchagnula R. Role of dissolution studies in controlled release drug delivery system. STP Pharma Sci. 1999; 9:157-68.
15. Rao PR, Ramakrishna S, Diwan PV. Drug release kinetics from polymeric films containing propanolol hydrochloride for transdermal use. Pharma Dev. Technol. 2000; 5: 465-72.
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