EFFECT OF BOUGAINVILLEA SPECTABILIS LEAVES ON SERUM LIPIDS IN ALBINO RATS FED WITH HIGH FAT DIET
Abstract
Dyslipidemia is major problem among population those have sedentary life style as well as in diabetics. Bougainvillea spectabilis is most commonly found in India as an ornamental plant and has got anti-diabetic action due to presence of one insulin mimicking agent D-pinitol (3-O-methyl-chiroinositol). The present investigation was undertaken to evaluate the effect of alcoholic extract of leaves of Bougainvillea spectabilis (AEBSL) on serum lipid profile in albino rats fed with high fat diet (HFD) and to compare it with a standard hypolipidaemic drug simvastatin. Thirty healthy albino rats of both sexes (100-200 g) were randomized into 5 groups of 6 animals each. The groups were treated as follows: Group A: normal diet (ND); Group B: HFD (vanaspati ghee + coconut oil mixture in ratio of 3:2 at 10 ml/kg/day); Group C: HFD+ AEBSL (100 mg/kg/day); Group D: HFD + AEBSL (200 mg/kg/day); Group E: HFD + simvastatin (1.8 mg/kg/day). Lipid profile was estimated after 8 weeks of treatment. AEBSL showed a significant (p<0.01) reduction in total cholesterol (TC), Triglyceride (TG), Low density lipoprotein (LDL), Very low density lipoprotein (VLDL) levels and significant (p<0.01) increase in high density lipoproteins (HDL) in hypercholesteromic rats (Group C and Group D). AEBSL 200 mg/kg/day found to be more effective than AEBSL 100 mg/kg/day. There is also significant improvement in atherogenic index (p<0.01) and increases the percentage of protection AEBSL treated animals. Alcoholic extract of leaves of Bougainvillea spectabilis leaves have excellent lipid lowering potentiality.
Keywords:
Bougainvillea spectabilis, High fat diet, Anti-hyperlipidemic activity, Hyperlipidemia, Atherogenic index.DOI
https://doi.org/10.25004/IJPSDR.2011.030214References
2. Zhang Xiaorui. WHO monographs on selected medicinal plants. Edn 1, Vol.1, A.I.T.B.S. Publishers& Distributors, Delhi, 2005, pp. 01—04.
3. Struwig M, Siebert S. An introduction to the Four-O’Clocks of southern Africa. Plant Life. 2010; 39 & 40: 66-70.
4. Gupta V, George M, Joseph L, Singhal M, Singh HP. Evaluation of antibacterial activity of Bougainvillea glabra ‘snow white’ and Bougainvillea glabra ‘choicy’. Journal of Chemical and Pharmaceutical Research 2009; 1: 233-237.
5. Saikia H, Das S. Antidiabetic action of Bougainvillea spectabilis (leaves) in normal and alloxan induced diabetic albino rats. Indian Drugs.2009; 46: 391-397.
6. Narayanan CR, Joshi DD, Mujumdar AM. Hypoglycemic action of Bougainvillea spectabilis leaves. Current Science. 1984; 53: 579-581.
7. Narayanan CR, Joshi DD, Mujumdar AM, Dhekne VV. Pinitol- A new Antidiabetic compound from the leaves of Bougainvillea spectabilis. Current Science 1987; 56:139-141.
8. Andrea B, Letizia P, Fabiola O, Paola V, Luigi B, Battelli MG et al. New ribosome inactivating proteins with polynucleotide: adenosine glycosidase and antiviral activities from Basella rubra L. and Bougainvillea spectabilis Willd. Planta. 1997; 203: 422—429.
9. Umamaheswari A, Shreevidya R, Nuni A. In vitro Antibacterial Activity of Bougainvillea spectabilis Leaves Extracts. Advan Biol Res. 2008; 2: 01-05.
10. Joshi DD, Mujumdar AM, Narayanan CR. Anti-inflammatory activity of Bougainvillea spectabilis leaves. Indian Journal of Pharmaceutical Sciences.1984; 46: 187-188.
11. Ali MS, Ibrahim SA, Ahmed F, Pervez MK. Colour versus bioactivity in the flowers of Bougainvillea spectabilis (Nyctaginaceae). Nat Prod Res.2005; 19: 1—5.
12. Mishra N, Joshi S, Tandon VL, Munjal A. Evaluation of Anti-fertility Potential of aqueous extract of Bougainvillea spectabilis leaves in swiss albino mice. International Journal of Pharmaceutical Science and Drug Research. 2009; 1:19-23.
13. Bates SH, Jones RB, Bailey CJ. Insulin-like effect of pinitol. British Journal of Pharmacology. 2000; 130:1944 - 1948.
14. Malomo SO, Adebayo JO, Arise RO, Olorunniji FJ, Egwim EC. Effects of Ethanolic Extract of Bougainvillea spectabilis Leaves on Some Liver and Kidney Function Indices in Rats. Phytochemistry & Pharmacology-III. 2006; 17:261-272.
15. Edwin E, Sheeja E, Toppo E, Tiwari V, Dutt KR.Anti-diarrhoeal, anti ulcer and antimicrobial activities of leaves of Bougainvillea glabra Choisy. Ars Pharm. 2007; 48: 135-144.
16. Adebayo GI, Alabi OT, Owoyele BV, Ayodele O, Soladoye AO. Anti-diabetic properties of the aqueous leaf extract of Bougainvillea glabra (Glory of the Garden) on Alloxan-Induced Diabetic Rats. Record of Natural Products. 2009; 3:187-192.
17. Geethan PKMA, Prince PSM. Antihyperlipidemic effect of D-pinitol on streptozotocin - induced diabetic Wistar rats. Journal of Biochemical and molecular Toxicology. 2008; 22: 220-224.
18. Ghosh MN. Fundamentals of experimental Pharmacology. Edn 3, Hilton and company, Calcutta, 2005: pp. 191-201.
19. Shyamala MP, Venukumar MR, Latha MS. Antioxidant potential of the Syzygium aromaticum (Gaertn) Linn (Cloves) in rats fed with high fat diet. Indian Journal of pharmacology. 2003; 35: 99-103.
20. Friedwald WT, Levy RI, Frederickson DS. Estimation of LDL Cholesterol in plasma without preparation of ultracentrifuge. Clin Chem. 1972; 18: 449-502.
21. Schulpis K, Karikas GA. Serum Cholesterol and triglyceride distribution in 7737 school aged Greek children. Paediatrics. 1998; 101: 861-864.
22. Dhandapani R. Hypolipidemic activity of Eclipta prostrata (L.) L. leaf extract in atherogenic diet induced hyperlipidemic rats. Indian J Exp Biol. 2007; 45: 617-619.
23. Yakubu MT, Afolayan AJ. Effect of aqueous extract of Bulbine natalensis Baker stem on haematological and serum lipid profile of male Wister rats. Indian J Exp Biol 2009; 47:283-288.
24. Treasure CB, Klein JL, Weintraub WS, Talley JD, Stillabow ME, Kisonski AS et al. Beneficial effects of cholesterol lowering therapy on the coronary endothelium in patients with coronary heart disease. N Engl J Med. 1995; 332: 481-487.
25. Chia BL. Cholesterol and coronary artery disease- issues in the 1990s. Singapore Med J. 1991; 32:291-294.
26. Yakubu MT, Akanji MA, Oladiji AT. Alterations in serum lipid profile of male rats by oral administration of aqueous extract of Fadogia agrestis stem. Res J Med Plant 2008; 2: 66-73.
27. Nandeesha H, Sathiyapria V, Bobby Z, Selvaraj N, pavithran P, Agrawal A. Atherogenic lipid risk factors in men classified as overweight and obese according to the preliminary WHO guidelines for Asians. Indian J Physiol Pharmacol. 2008; 52: 205-208.
28. Lu W, Resnick HE, Jablonski KA, Jones KL, Jain AK, Howard WMJ et al. Non-HDL Cholesterol as a Predictor of Cardiovascular Disease in Type 2 Diabetes: The Strong Heart Study. Diabetes Care. 2003; 26:16–23.
29. Botham KM, Mayes PA. Harper’s illustrated Biochemistry. Edn 26, The McGraw-Hill Companies Inc. New York, 2006, pp. 217-245.
30. Adebayo JO, Adesokan AA, Olatunji LA, Buoro DO, Soladoye AO. Effect of ethanolic extract of Bougainvillea spectabilis leaves on haematological and serum lipid variables in rats. Biokemistri. 2005; 17:45-50.
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