FORMULATION AND EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF POORLY SOLUBLE DRUG USING VARYING CHAIN SURFACTANTS
Abstract
In the present study, the aim was to formulate self-emulsifying drug delivery system of mefenamic acid. Two homologous surfactants of Tween series, Tween 20 and Tween 40 were used as surfactants. The two surfactants were used to formulate a self-emulsifying system of mefenamic acid using a common co-surfactant ethanol. The clear microemulsion regions obtained in phase diagram of Tween 40 was larger than Tween 20; which indicates that Tween 40 has good emulsifying ability. Tween 20 has a hydrophobic chain length of 12 carbons, whereas Tween 40 has a hydrophobic chain length of 16 carbons, so increment in carbon chain length provides good self-emulsifying ability due to better shielding of the hydrophobic core. This inference is further consolidated after formulating six different formulations using the two surfactants and subjecting them to various evaluation parameters. The formulations containing Tween 40 were superior in all the evaluation parameters, including particle size, zeta potential, and drug release rate. The optimized formulation’s particle size, zeta potential, and drug release rate (in 60 minutes) were 187.20 nm, -22.2 mV, and 90.42%, respectively.
Keywords:
Self emulsifying drug delivery system, particle size, zeta potential, pseudoternary phase diagram, surfactantsDOI
https://doi.org/10.25004/IJPSDR.2021.130403References
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