SYNTHESIS AND EVALUATION OF ANTIOXIDANT ACTIVITY OF SEMICARBAZONE DERIVATIVES

Authors

  • Manmohan Singhal School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
  • Arindam Paul G D Memorial College of Pharmacy, Jodhpur, Rajasthan, India
  • Hemendra Pratap Singh B N College of Pharmacy, Udaipur, Rajasthan, India
  • Sushil Kumar Dubey School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India
  • Rajendra K. Songara School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India

Abstract

In present study, a series of chalconesemicarbazones was synthesized and evaluated for antioxidant activity by DPPH free radical scavenging assay. Most of the compounds were found to be potent antioxidant. Free radicals play an important role in various pathological and xenotoxic effects so antioxidant may have protective role in these pathological conditions. Based on the results of an anti-oxidant study, Compound 23 was the most active compound. The highest scavenger activity observed in compound 23 is probably due to the presence of hydroxyl group in the acetophenic moiety and methoxy group in aldehydic moiety of chalcone. It was found that methoxy and hydroxyl substituted chalconesemicarbazones were potent nitric oxide scavenger and unsubstituted compound showed very less activity.

Keywords:

Chalcones, Anti-oxidant, Semicarbazones, DPPH scavenging.

DOI

https://doi.org/10.25004/IJPSDR.2011.030216

References

1. Setiadi DH, Chass GA, Torday LL, Varro A, Papp JG. Vitamin E models. Can the antioxidants and pro-antioxidant dichotomy of α-tocopherol be related to ionic ring closing and radical ring opening redox reactions? Journal of molecular structure 2003; 620:93-106.
2. Halliwell B, Gutteridge JMC. Free radicals in biology and medicines. Oxford University Press, Oxford 1985.
3. Nickels W. The mystery of non-classical protein secretion. European journal of biochemistry 2003; 270: 2109-2119.
4. Dutta S, Padhye S, Priyadarsini KI, Newton C. Antioxidant and antiproliferative activity of curcumin semicarbazone. Bioorganic & Medicinal Chemistry Letters 2005; 15: 2738–2744.
5. Sanchez-Moreno C, Larraui A, Saura-Calixto F. A procedure to measure the antiradical efficiency of polyphenols. J Sci Food Agri. 1998; 76: 270.
6. Oktay M, Gulein I, Kufreviolglu I, Labenson-Wiss U. Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts. Technol. 2003; 36: 263-71.
7. Tagashira M, Ohtake Y. A new antioxidative 1, 3-benzodioxole from Melissa officinalis. Planta Med 1998; 64:555–558.
8. Vijay KH, Gnanendra CR, Nagaraja N, Channe Gowda D. In vitro antioxidant activity of Dibenz [b, f] azepine and its analogues. E-J. Chemistry 2008; 5(S2): 1123-1132.
9. Venkateswarlu S, Ramchandra MS, Krishnaraju AV, Trimurtulu G, Subbaraju GV. Antioxidant and antimicrobial activity evaluation of polyhydroxycinnamic acid ester deravatives. Indian J. Chemistry 2005; 45B: 252-257.
10. Singh D, Mohan S, Sharma PC, Sarvanan J. Synthesis and evaluation of some novel thiophenes as potential antioxidant and anti-inflammatory agents. Acta Pharmaceutica Sciencia 2007; 49: 29-38.
11. Allegra M, Reiter RJ, Tan DX, Gentile C, Tesoriere L, Livrea MA. The chemistry of melatonin’s interaction with reactive species. J. Pineal Res. 2003; 34: 1-10.

Published

01-04-2011
Statistics
Abstract Display: 268
PDF Downloads: 403
Dimension Badge

How to Cite

“SYNTHESIS AND EVALUATION OF ANTIOXIDANT ACTIVITY OF SEMICARBAZONE DERIVATIVES”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 2, Apr. 2011, pp. 150-4, https://doi.org/10.25004/IJPSDR.2011.030216.

Issue

Volume 3, Issue 2, 2011

Section

Research Article

How to Cite

“SYNTHESIS AND EVALUATION OF ANTIOXIDANT ACTIVITY OF SEMICARBAZONE DERIVATIVES”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 2, Apr. 2011, pp. 150-4, https://doi.org/10.25004/IJPSDR.2011.030216.