NOVEL BENZIMIDAZOLE ACETAMIDE DERIVATIVES AS ANTIBACTERIAL AND ANTI-TUBERCULAR AGENTS: SYNTHESIS AND CHARACTERIZATION

Authors

  • Farhana Hakim Department of Pharmacy, Career Point University, Kota, Rajasthan-325003, India
  • Roshan Salfi Department of Pharmacy, Career Point University, Kota, Rajasthan-325003, India

Abstract

The current study focused on the development of novel potentially active anti-microbial agents based on the benzimidazole-acetamide system. A novel series of various substituted benzimidazole- N- phenyl acetamides was synthesized through a feasible scheme characterized by IR, Proton nuclear magnetic resonance (1HNMR), and MASS spectral methods. All the synthesized compounds were screened for anti-bacterial activity against two gram-positive strains: Staphylococcus aureus, Bacillus subtilis; four gram-negative strains: Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, and Klebsiella pneumonia; and anti-tubercular activity against mycobacterial strain: Mycobacterium tuberculosis. Among the 15 compounds (6a–6o) tested, three compounds, 6e, 6f, 6l, and 6m demonstrated high potency with MIC values ranging from 6.25–12.5μg/mL against both gram-positive and gram-negative strains. In addition, compounds 6e, 6f, and 6l displayed the highest anti-tubercular activity with a MIC value of 25μg/mL.

Keywords:

Benzimidazole, Acetamide, Antibacterial activity, Anti -tubercular activity,

DOI

https://doi.org/10.25004/IJPSDR.2021.130310

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Published

30-05-2021
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“NOVEL BENZIMIDAZOLE ACETAMIDE DERIVATIVES AS ANTIBACTERIAL AND ANTI-TUBERCULAR AGENTS: SYNTHESIS AND CHARACTERIZATION”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 13, no. 3, May 2021, pp. 303-10, https://doi.org/10.25004/IJPSDR.2021.130310.

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Research Article

How to Cite

“NOVEL BENZIMIDAZOLE ACETAMIDE DERIVATIVES AS ANTIBACTERIAL AND ANTI-TUBERCULAR AGENTS: SYNTHESIS AND CHARACTERIZATION”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 13, no. 3, May 2021, pp. 303-10, https://doi.org/10.25004/IJPSDR.2021.130310.