ANTITUSSIVE MEDICINAL HERBS - AN UPDATE REVIEW
Abstract
The cough is a protective reflex mechanism that removes foreign material and secretions from the bronchi and bronchioles of the airways; it is inappropriately stimulated in various situations like inflammation of the respiratory tract or neoplasia. In these cases, cough has a pathological character and it is necessary sometimes to use cough-suppressant drugs. The most frequently used antitussive drugs in clinical conditions produce adverse effects like depression of the respiratory centre, decreased secretion in the bronchioles and inhibition of ciliary activity, increased sputum viscosity, decreased expectoration, hypotension and constipation acts as limitation to the therapy. Use of herbal drugs is increasing all over the world for various ailments including antitussive activity as they are safe and devoid of adverse effects. Medicinal plants are an important source for the discovery of novel bioactive compounds, which have served and continue to serve as lead molecules for the development of new drugs. Thus this review may provide an insight into herbs possessing antitussive activity.
Keywords:
Cough, antitussive herbs, expectorants, cough suppressantsDOI
https://doi.org/10.25004/IJPSDR.2014.060102References
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21. Ballba SI, Hilal SH, and Haggag MY. The volatile oil from the herb and fruits of Carum copticum at different stages of growth. Planta Medica. 1973; 23:312-319.
22. Gersbach PV, Reddy N. Non-invasive localization of thymol accumulation in Carum copticum (apiaceae) fruits by chemical shift selective magnetic resonance imaging. Annals Botany 2002; 90:253-257.
23. Forsberg K, Karlsson JA, Theodorsson E, Lundberg JM. Persson. Cough and broncho constriction mediated by capsaicin sensitive sensory neurons in guinea pigs. Pulmonary Pharmacology 1988; 1(33):39.
24. Karlsson JA, Lanner AS, Persson GA. Airway opioid receptors mediate inhibition of cough and reflex broncho constriction in guinea pigs. Journal of Pharmacology and Experimental Therapeutics 1990; 252:863-868.
25. Boskabady MH, Jandaghi P, Kiani S, Hasanzadeh L. Antitussive effect of Carum copticum in guinea pigs. Journal of Ethnopharmacology. 2005; 97:79-82.
26. Rain tree nutrition. Tropical plant database file for Canafistula (Casia fistula) (http://www.rain-tree.com/canafistula.html).Viewed 21.10.2013.
27. Bhakta T, Pulok KM, Kakali S, Pal M, Saha BP. Studies in antitussive activity of Cassia afistula (Leguminosae) leaf extract. Pharmaceutical Biology 1998; 36(2):140-143.
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29. Hossein H, Jafar G. Evaluation of antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranol and crocin in guinea pigs. Fitoterapia 2006; 77:446-448.
30. Botanical.com. A modern herbal. Cumin. (http://botanical.com/ botanical/mgmh/c/cumin 127.html). Viewed on 21.11.2013.
31. Mohammad HB, Sahar K, Hoda A, Tahereh K. Antitussive effect of Cuminum cyminum Linn. in guinea pigs. Natural Product Radiance. 2006; 5(4):266-269.
32. Srivastava TN, Kaphi BK. Medicinal and aromatic plant resources of Sikkim, Himalaya. Journal of Economic Taxonomic Botany. 1992; 16(1):17.
33. Dutta SK, Banerjee G. Chemical control of some weeds of Darjeeling. Science and Culture. 1954; 20:191-193.
34. Asolkar LV, Kakkar KK, Chakre OJ. Second Supplement to Glossary of lndian Medicinal Plants, Publication and Information Directoratem, (C.S.I.R., New Delhi,India.) 1992.
35. Rao RR. Ethnobotany of Meghalaya: medicinal plants used by Khasi and Garo tribes. Economic Botany. 198l; 35:49.
36. Miyagoshi M, Amagaya S, Ogihara Y. Antitussive effects of l,-ephedrine, amygdalin and makyokansokito (Chinese traditional medicine) using a cough model induced by sulfur dioxide gas in mice. Planta Medica. 1986; 52:275-278.
37. Pulok Mukherjee K, Kakali S, Bhattacharya SN, Giri M, Pal BP, Saha. Studies on antitussive activity of Drymaria cordata Willd. (Caryophyllaceae). Journal of Ethnopharmacology. 1997; 56:77-80.
38. Bhattacharya A, Chatterjee A, Ghosal S, Bhattacharya SK. Antioxidant activity of active tannoid principles of Emblica officinalis. Ind J Exp Biol. 1999; 37(7):676-680.
39. Ihantola-Vormisto A, Summanen J, Kankaanranta H, Vuorela H, Asmawi ZM, Moilanen E. Anti-inflammatory activity of extracts from leaves of Phyllanthus emblica. Planta Medica. 1997; 63(6):518-524.
40. Nosalova G, Mokry J, Tareq Hassan KM. Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae). Phytomedicine. 2003; 10:583-589.
41. Strapkova A, Nosalova G, Korpas J. New aspects of the antitussive effects of codein. Bratisl Lek Listy. 1984; 81(2):182-187.
42. Nosalova G, Kardosova A, Franova S. Antitussive activity of a glucuronoxylan from Rudbeckia fulgida compared to the potency of two polysaccharide complexes from the same herb. Pharm. 2000; 55 (1):65-68.
43. Asano T, Murayama T, Hirai Y, Shoji J. Comparative studies on the constituents of ophiopogonins tuber and its congeners: VIII. Studies on the glycosides of the subterranean part of Ophiopogon japonicus Ker-Gawler cv. Nanus (2). Chemical Pharma Bulletin. 1993; 41:566-570.
44. Takahama K, Miyata T. Cough-diversity and the peripheral mechanisms of production. Folia Pharmacology Japan 1995; 105:41-52.
45. Kamei J, Nakamura R, Ichiki H, Kubo M. Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang). European Journal Pharmacology 2003; 469:159-163.
46. Sanogo R, De R, Pasquale, Germano MP. The Antitussive Activity of Guiera senegalensis J.F.Gmel (Combretaceae). Phytotherapy Research. 1998; 12:132-134.
47. Nadkararni KM, Nadkarani AK. Indian Materia Medica. Vol. I. Popular Prakashan: Bombay, India. 1976.
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“ANTITUSSIVE MEDICINAL HERBS - AN UPDATE REVIEW”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 1, Jan. 2013, pp. 12-19, https://doi.org/10.25004/IJPSDR.2014.060102.
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How to Cite
“ANTITUSSIVE MEDICINAL HERBS - AN UPDATE REVIEW”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 1, Jan. 2013, pp. 12-19, https://doi.org/10.25004/IJPSDR.2014.060102.
