ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF TERMINALIA CATAPPA LEAVES AGAINST GASTRIC ULCERS BY PYROLIC LIGATION INDUCED MODEL IN RATS
Abstract
Terminalia catappa family combretaceae moreover known as Indian almond was a large, spreading tree scattered throughout the tropics in coastal environments in India. Anti-ulcer activity of ethanolic extract of T. catappa (250 and 500 mg/kg b.w) was examined on pyrolic ligated induced ulcer model in rats. Omeprazole was used as standard. The anti-ulcer activity of T. catappa was evaluated with the help of ulcer index and histopathological examination. Preliminary phytochemical screening and acute toxicity studies of T. catappa also carried out. The extract showed significant (p < 0.001) reduction in pH, gastric volume, free acidity, total acidity and ulcer index in dose dependent manner as compared to control. The extract did not produce any toxic effects even at high doses. The anti-ulcer activity was probably due to the presence of flavonoids.
Keywords:
Terminalia catappa, Omeprazole, pyrolic ligation, ethanolic extract, Ulcer index, flavonoidsDOI
https://doi.org/10.25004/IJPSDR.2014.060106References
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15. Umamaheswari M, Ashok kumar K, Rathidevi R, Sivashanmugam AT, Subhadradevi V, Ravi TK. Antiulcer and in-vitro antioxidant activities of Jasminum grandiflorum L. J Ethnopharm. 2007; 110: 464-470.
16. Piper DW, Stiel DD. Pathogenesis of chronic peptic ulcer, current thinking and clinical implications. Med Prog. 1986; 2: 7-10.
17. Dhuley JN. Protective effect of Rhinax, an herbal formation against physical and chemical factors induced gastric and duodenal ulcers in rats. Indian J Pharmacol. 1999; 31: 128-32.
18. Sairam K, Rao Ch.V, Dora Babu M, Agrawal VK, Goel RK. Antiulcerogenic activity of methanolic extract of Emblica officinalis. Journal of Ethnopharmacology 2002; 82(1):1-9.
2. Akhtar MS, Akhtar AH, Makhan. Anti-ulcerogenic effects of Ocimum bailicm extract volatite oil and flavonoid glycosides in albino rats. International Journal of Pharmacognosy 1992; 30: 97-104.
3. Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin like drugs. Nature 1971; 231: 232-235.
4. Masuda T, Yonemori S, Oyama Y, Tekeda Y, Tanaka T, Andoh T, Shinohara A, Nakata M. Evaluation of the antioxidant activity of Environmental plants activity of the leaf extracts from sea shore plants. Journal of Agricultural and Food chemistry 1999; 47:1749-1754.
5. Tan GT, Pezzuto JM, Kinghorn AD and Hughes SH. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV -1) reverse transcriptase. Journal of Natural Products 1991: 54:143-154.
6. Lin CC, Chen YL, Lin JM and Ujiie T. Evaluation of the antioxidant and hepatoprotective activitiy of Terminalia catappa. The American Journal of Chinese medicine 1997:25:153-161.
7. Lin CC, Chen YL. TC Effects of punicalin on carrageenan-induced inflammation in Rats. The American Journal of Chinese Medicine. 1999: 27: 371-376.
8. Chen P.S, Li JH, Liu JY, Lin TC. Folk medicine Terminalia catappa and its major tannin component, punicalagin, are effective against bleomycin induced genotoxicity in Chinese hamster ovary cells. Cancer Letters 2000; 52: 115-122.
9. Nagappa AN, Thakurdesai PA, Venkat Rao N, Singh J. Antidiabetic activity of Terminalia catappa Linn fruits. Journal of Ethonopharmacology 2003; 88:45-50.
10. Ratnasooriya WD, Dharmasiri MG. Effects of Terminalia catappa seeds on sexual behavior and fertility of male rats. Asian Journal of Andrology 2000; 2: 213-266.
11. Sahil T. Anti-inflammatory activities of Terminalia paniculata bark extract against acute and chronic inflammation in rats. Journal of Ethnopharmacology 2010; 134(2): 323-328.
12. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 2nd edition, Nirali Prakashan, Pune, 2007; 508-525.
13. Alaghawani W, Naser I. Study the Hypoglycemic Effect of Crataegus Laevigata in Diabetic Rats. International Journal of Pharmaceutical and Clinical Research 2013; 5(4):145-149.
14. Turner RA. Screening methods in pharmacology. New York: Academic press. 1965, pp. 302-304.
15. Umamaheswari M, Ashok kumar K, Rathidevi R, Sivashanmugam AT, Subhadradevi V, Ravi TK. Antiulcer and in-vitro antioxidant activities of Jasminum grandiflorum L. J Ethnopharm. 2007; 110: 464-470.
16. Piper DW, Stiel DD. Pathogenesis of chronic peptic ulcer, current thinking and clinical implications. Med Prog. 1986; 2: 7-10.
17. Dhuley JN. Protective effect of Rhinax, an herbal formation against physical and chemical factors induced gastric and duodenal ulcers in rats. Indian J Pharmacol. 1999; 31: 128-32.
18. Sairam K, Rao Ch.V, Dora Babu M, Agrawal VK, Goel RK. Antiulcerogenic activity of methanolic extract of Emblica officinalis. Journal of Ethnopharmacology 2002; 82(1):1-9.
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01-01-2014
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“ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF TERMINALIA CATAPPA LEAVES AGAINST GASTRIC ULCERS BY PYROLIC LIGATION INDUCED MODEL IN RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 1, Jan. 2014, pp. 38-40, https://doi.org/10.25004/IJPSDR.2014.060106.
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How to Cite
“ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF TERMINALIA CATAPPA LEAVES AGAINST GASTRIC ULCERS BY PYROLIC LIGATION INDUCED MODEL IN RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 1, Jan. 2014, pp. 38-40, https://doi.org/10.25004/IJPSDR.2014.060106.
