EXTRACTIVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GABAPENTIN IN PHARMACEUTICAL DOSAGE FORMS

Authors

  • Brijesh Patel Department of Pharmaceutical Chemistry, Sat Kaival College of Pharmacy, Paramguru Pathshala Complex, Sarsa Cross Roads, Sarsa At-Po: - Sarsa, Ta & Dist: - Anand, Gujarat, India-388365
  • Japan Patel Department of Pharmaceutical Chemistry, Sat Kaival College of Pharmacy, Paramguru Pathshala Complex, Sarsa Cross Roads, Sarsa At-Po: - Sarsa, Ta & Dist: - Anand, Gujarat, India-388365
  • Hardeep Singh Department of Pharmaceutical Chemistry, Sat Kaival College of Pharmacy, Paramguru Pathshala Complex, Sarsa Cross Roads, Sarsa At-Po: - Sarsa, Ta & Dist: - Anand, Gujarat, India-388365
  • Bhagirath Patel Department of Pharmaceutical Chemistry, Sat Kaival College of Pharmacy, Paramguru Pathshala Complex, Sarsa Cross Roads, Sarsa At-Po: - Sarsa, Ta & Dist: - Anand, Gujarat, India-388365

Abstract

Two simple, rapid, sensitive, accurate, precise and economic spectrophotometric methods have been developed for the estimation of Gabapentin (GBP) in pharmaceutical formulations. During the course of study, it was observed that acidic solution of the drug formed colored ion-association complexes with Bromocresol Green (BCG) (Method I) and Bromothymol Blue (BTB) (Method II) which were soluble in chloroform. This property of the drug was followed for the development of colorimetric methods for analysis of drug. The complex of GBP with BCG and BTB showed λmax at 416 nm and 421 nm, respectively. The linearity range for GBP was 10-120 µg ml-1 and 40-90 µg ml-1 for BCG and BTB, respectively. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The proposed methods are found to be simple, accurate and reproducible those were successfully applied for the analysis of pharmaceutical dosage forms.

Keywords:

Gabapentin (GBP), Colorimetric analysis, Bromocresol Green (BCG), Bromothymol Blue (BTB), Extractive spectrophotometry.

DOI

https://doi.org/10.25004/IJPSDR.2011.030306

References

1. Weintraub D, Buchsbaum R, Resor SR, Hirsch LJ. Psychiatric and behavioral side effects of the newer antiepileptic drugs in adults with epilepsy. Epilepsy and Behavior. 2007; 10(1): 105-110.
2. United States Pharmacopeia, 30th ed., The United States Pharmacopeial convention Inc., Rockville, 2007; pp. 2200.
3. Ifa DR, Falci M, Moraes ME, Bezerra FA, Moraes MO, de Nucci G. Gabapentin quantification in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry: Application to bioequivalence study. J Mass Spectrom 2001; 36(2): 188-94.
4. Kushnir MM, Crossett J, Brown PI, Urry FM. Analysis of Gabapentin in serum and plasma by solid-phase extraction and gas chromatography-mass spectrometry for therapeutic drug monitoring. J Anal Toxicol 1999; 23(1):1-6
5. Garcia LL, Shihabi ZK, Oles K. Determination of Gabapentin in serum by capillary electrophoresis. J Chromatogr B Biomed Appl 1995; 669(1):157-62.
6. Jalali F, Arkan E, Bahrami G. Preparation of a Gabapentin potentiometric sensor and its application to pharmaceutical analysis.Sen Actu B Chem 2007;127 (1): 304-309.
7. Hassan EM, Belal F, Al-Deeb OA, Khalil NY. Spectrofluorimetric determination of vigabatrin and Gabapentin in dosage forms and spiked plasma samples through derivatization with 4-chloro-7-nitrobenzo-2-oxa-1, 3-diazole. J AOAC Int 2001; 84(4):1017-24.
8. Abdellatef HE, Khalil HM. Colorimetric determination of Gabapentin in pharmaceutical formulation. J Pharm Biomed Anal 2003; 5,31(1):209-14
9. Indian Pharmacopoeia, Vol. I, Govt. of India, Ministry of Health and Family Welfare, New Delhi 2007; 477-480, 540-541.
10. Sastry CSP, Petla NY, Murthy SSN. Indian J Pharm Sci 1997; 59(3): 124.

Published

01-07-2011
Statistics
Abstract Display: 240
PDF Downloads: 343
Dimension Badge

How to Cite

“EXTRACTIVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GABAPENTIN IN PHARMACEUTICAL DOSAGE FORMS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 3, July 2011, pp. 197-01, https://doi.org/10.25004/IJPSDR.2011.030306.

Issue

Volume 3, Issue 3, 2011

Section

Research Article

How to Cite

“EXTRACTIVE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GABAPENTIN IN PHARMACEUTICAL DOSAGE FORMS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 3, July 2011, pp. 197-01, https://doi.org/10.25004/IJPSDR.2011.030306.