ABROGATION OF STAPHYLOCOCCUS AUREUS WOUND INFECTION BY BACTERIOPHAGE IN DIABETIC RATS

Authors

  • Vinod Kumar C.S Department of Microbiology, S. S. Institute of Medical Sciences and Research Centre, Davangere-577005, Karnataka, India
  • Srinivasa H Department of Microbiology, St. Johns Medical College, Bangalore, Karnataka, India
  • Basavarajappa K.G Department of Microbiology, S. S. Institute of Medical Sciences and Research Centre, Davangere-577005, Karnataka, India
  • Umakanth Patil Department of Pharmacology, S. S. Institute of Medical Sciences and Research Centre, Dava
  • Nitin Bandekar Department of Surgery, S. S. Institute of Medical Sciences and Research Centre, Davangere-577005, Karnataka, India
  • Rajashri Patil Department of Community Medicine, S. S. Institute of Medical Sciences and Research Centre, Davangere-577005, Karnataka, India

Abstract

To evaluate therapeutic potential of phages specific for Staphylococcus aureus to resolve wound infection in diabetic rats. The objective of the study is for the assessment of wound healing activity, excision wound model was used. Group I was assigned as control, Group II infected with methicillin resistant Staphylococcus aureus (MRSA), Group III non infected and received only phage preparation to assess whether phage initiates infection, Group IV infected with MRSA, once the infection was established it was challenged with Staphylococcus aureus phages and Group V infected MRSA and treated with antibiotic Clindamycin after 4th day of infection. A significant decrease in infection, period of epithelization and wound contraction was observed in the phage challenged group when compared to antibiotic treated diabetic rats and the control group. To conclude the study provide new insights into the biology of the broad host range of Staphylococcus aureus phage Ø SH-56 and indicate that phage has potential for treatment and prevention of infections caused by pathogenic staphylococci.

Keywords:

Methicillin resistant Staphylococcus aureus, diabetic rats, bacteriophage.

DOI

https://doi.org/10.25004/IJPSDR.2011.030307

References

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Published

01-07-2011
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How to Cite

“ABROGATION OF STAPHYLOCOCCUS AUREUS WOUND INFECTION BY BACTERIOPHAGE IN DIABETIC RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 3, July 2011, pp. 202-7, https://doi.org/10.25004/IJPSDR.2011.030307.

Issue

Volume 3, Issue 3, 2011

Section

Research Article

Copyright (c) 2011 Vinod Kumar C.S, Srinivasa H, Basavarajappa K.G, Umakanth Patil, Nitin Bandekar, Rajashri Patil

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

“ABROGATION OF STAPHYLOCOCCUS AUREUS WOUND INFECTION BY BACTERIOPHAGE IN DIABETIC RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 3, July 2011, pp. 202-7, https://doi.org/10.25004/IJPSDR.2011.030307.