A NEW FACILE AND SENSITIVE METHOD FOR THE ESTIMATION OF TAPENTADOL
Abstract
A simple, economical, precise, reliable and reproducible visible Spectrophotometric method has been developed for the estimation of Tapentadol in bulk as well as in tablet formulations. This method is based on the formation of Blood red colored chromogen with2, 2 -bipyridyl which shows maximum absorption at λ max 520 nm. The absorbance-concentration plot is linear over the range 50-250µg/mL. Results of analysis were validated statistically. Recovery studies were also performed. The proposed method is economical, accurate precise and sensitive for the estimation of Tapentadol in bulk drug and its formulation.
Keywords:
Tapentadol, 2, 2- bipyridyl, Blood red colored, Visible SpectrophotometricDOI
https://doi.org/10.25004/IJPSDR.2014.060115References
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7. Deva Dasu Ch, Eshwar G, Silpa kala E, Shalini Mani RN, Lavanya N S L, Krupa rao A, Srikanth V, Srinivasa P. Development of New Spectrophotometric Methods for the Quantitative Analysis of Tapentadol in Pharmaceutical Dosage Forms. Current Pharma Research 2012; 3-1:718-726.
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9. Gandhi J, Shah NJ., Lumbhani AN. Simple, rapid and cost effective method for routine analysis of tapentadol hydrochloride: A novel analgesic drug in bulk and pharmaceutical dosage form by RP-HPLC.Pharma Science Monitor. 2012; 0976-7908: 2440-2453.
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2. Schedules of controlled substances: placement of tapentadol into schedule II. Final rule. Fed. Regist. 2009; 74(97): 23790-23793.
3. Thomas M, Christoph T, Babette Kögel, Klaus Schiene, Hagen-Heinrich H, Werner Englberger, Michael H, Jahnel U, Thomas I. F. H., Friderichs E, Jean De Vry. A Novel μ-Opioid Receptor Agonist/Norepinephrine Reuptake Inhibitor with Broad-Spectrum Analgesic Properties. Journal of Pharmacology and Experimental Therapeutics 2007; 323:265-276.
4. Coulter C, Taruc M, Tuyay J, Moore C. Determination of tapentadol and its metabolite N-desmethyltapentadol in urine and oral fluid using liquid chromatography with tandem mass spectral detection. J. Anal. Toxicol. 2010; 34:458-463.
5. Bourland JA, Collins AA, Chester SA, Ramachandran S, Backer RC. Determination of tapentadol (Nucynta®) and N-desmethyltapentadol in authentic urine specimens by ultra-performance liquid chromatography-tandem mass spectrometry, J. Anal. Toxicol. 2010; 34:450-457.
6. Sherikar OD, Mehta PJ. Development and Validation of RP- HPLC, UV-Spectrometric and Spectrophotometric Method for Estimation of Tapentadol Hydrochloride in Bulk and in Laboratory Sample of Tablet Dosage Form. Journal of Chemical and Pharmaceutical Research 2012; 4(9):4134-4140.
7. Deva Dasu Ch, Eshwar G, Silpa kala E, Shalini Mani RN, Lavanya N S L, Krupa rao A, Srikanth V, Srinivasa P. Development of New Spectrophotometric Methods for the Quantitative Analysis of Tapentadol in Pharmaceutical Dosage Forms. Current Pharma Research 2012; 3-1:718-726.
8. Ramesh PK, Tejash PP, Kaushik GK, Shital DF. Method Development and Validation of tapentadol hydrochloride by RP-HPLC Method, Inventi Impact: Pharm Analysis & Quality Assurance 2012.
9. Gandhi J, Shah NJ., Lumbhani AN. Simple, rapid and cost effective method for routine analysis of tapentadol hydrochloride: A novel analgesic drug in bulk and pharmaceutical dosage form by RP-HPLC.Pharma Science Monitor. 2012; 0976-7908: 2440-2453.
10. Giorgim M, Meizler A, Mills PC. Quantification of tapentadol in canine plasma by HPLC with spectrofluorimetric detection: Development and validation of a new methodology. J. Pharm. Biomed. Anal. 2012; 67:148.
11. Mokhtar M, Hamed M, Sherin F, Mohamed A. Spectrophotometric Methods for Determination of Tapentadol Hydrochloride. J App Pharm Sci. 2013; 3(03): 122-125.
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01-01-2014
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“A NEW FACILE AND SENSITIVE METHOD FOR THE ESTIMATION OF TAPENTADOL”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 1, Jan. 2014, pp. 82-84, https://doi.org/10.25004/IJPSDR.2014.060115.
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Copyright (c) 2014 Y.Kranthi Kumar, K.Vanitha Prakash, Mogili Swetha
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“A NEW FACILE AND SENSITIVE METHOD FOR THE ESTIMATION OF TAPENTADOL”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 1, Jan. 2014, pp. 82-84, https://doi.org/10.25004/IJPSDR.2014.060115.
