POLYOX (POLYETHYLENE OXIDE) MULTIFUNCTIONAL POLYMER IN NOVEL DRUG DELIVERY SYSTEM
Abstract
Polymers are tools used in novel drug delivery system to modify the drug release of pharmaceutical dosage form. Polyox is hydrophilic polymer made of non-ionic homopolymer of ethylene oxide. Polyox is popular for its film forming, binding, lubricating, mucoadhesive, viscosity imparting property in pharmaceuticals. Polyox are available in various grades based on its molecular weight. Lower molecular weight Polyox are widely used for immediate drug release based on erosion properties of the polymer like quick dissolving film and high molecular weight Polyox are used to retard the drug release based on swelling and erosion properties of the polymer in controlled release, sustained release, extended release, buccal films, ocular inserts, ocular gels, osmotic tablets and so on. Polyox plays an important role in design of a novel drug delivery system for both highly and poorly soluble drug due to its multifunctional property. This review is detailed on Polyox its advantages, disadvantages, salient feature, mechanism, stability and application in pharmaceutical dosage form.
Keywords:
Polymers, Polyox, swelling, erosion, novel drug delivery systemDOI
https://doi.org/10.25004/IJPSDR.2014.060203References
1. Chandel P, Kapoor A. polymer: a boon to controlled drug delivery system. Int. Res. J. Pharm. 2013; 4(4):28-34.
2. http://msdssearch.dow.com/PublishedLiteratureDOWCOM/dh_0031/0901b80380031a4a.pdf?filepath=/pdfs/noreg/326-00001.pdf&fromPage=GetDoc
3. http://www.colorcon.com/literature/marketing/mr/Extended%20Release/POLYOX/English/ads_Polyox_form_peo_matrices.pdf
4. Kojima H, Yoshihara K, Sawada T. Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics 2008; 70: 556-562.
5. USP/ NF 2009 pg no. 1312
6. Chowdary KP, Deepthi KS, Rao S. Mucoadhesive Microcapsules of Indomethacin: Evaluation for Controlled Release and Ulcerogenic Activity. International Journal of Pharmaceutical Sciences and Drug Research 2009; 1(2): 74-79.
7. Yang L, Venkatesh G, Fassihi R. Characterization of compressibility and compactibility of poly (ethylene oxide) polymers for modified release application by compaction simulator. J. Pharm. Sci. 1996; 85:1085-1090.
8. Maggi L, Bruni R, Conte U. High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms. International Journal of Pharmaceutics 2000; 195: 229-238.
9. Deshkar S, Pawar M, Shirsat A, Shirolkar S. Development of sustained release tablet of Mebeverine hydrochloride. J Pharm Educ Res. 2013;4(1):64-69
10. Vidyadhara S, Sasidhar RLC, Nagaraju R. Design and Development of Polyethylene Oxide Based Matrix Tablets for Verapamil Hydrochloride. Indian J Pharm Sci.2013; 75(2):185-190.
11. Dimitrov M, Lambov N. Study of verapamil hydrochloride release from compressed hydrophilic Polyox-Wsr tablets. International Journal of Pharmaceutics. 1999; 189:105-111.
12. Kim C. Drug release from compressed hydrophilic POLYOX-WSR tablets, J. Pharm. Sci. 1995; 84: 303-306.
13. Cappello B, Del Nobile MA, La Rotonda MI, Mensitieri G, Miro A, Nicolais L. Water soluble drug delivery systems based on a non-biological bioadhesive polymeric system. Farmaco. 1994; 49(12):809-818.
14. Cappello B, De Rosa G, Giannini L, La Rotonda MI, Mensitieri G, Miro A, Quaglia F, Russo R. Cyclodextrin-containing poly (ethyleneoxide) tablets for the delivery of poorly soluble drugs: potential as buccal delivery system. Int J Pharm. 2006; 319(1-2):63-70.
15. Bukka R, Dwivedi M, Nargund LVG, Prasam K. Formulation and Evaluation of Felodipine Buccal Films containing Polyethylene Oxide. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012; 3 (3):1153-1158.
16. Di Colo G, Burgalassi S, Chetoni P. Gel-forming erodible inserts for ocular controlled delivery of ofloxacin. International Journal of Pharmaceutics. 2001; 215(1-2): 101-111.
17. http://www.colorcon.com/literature/marketing/fc/Opadry%20CA/AAPS2012_oyca_ppop_variousdrug.pdf
18. Waterman KC, Goeken G, Konagurthu S, Likar MD, MacDonald BC, Mahajan N, Swaminathan V. Osmotic capsules: A universal oral, controlled-release drug delivery dosage form. Journal of Controlled Release. 2011; 152: 264-269.
19. Jagdale SC, Bari NA, Kuchekar BS, Chabukswar AR. Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol. BioMed Research Intenational 2013; Article ID 801769, 11 pages. http://dx.doi.org/10.1155/2013/801769
20. Bomma R, Veerabrahma K. Development of gastroretentive drug delivery system for cefuroxime axetil: In vitro and in vivo evaluation in human volunteers. Pharm Dev Technol. 2013 Sep-Oct; 18(5):1230-7. doi: 10.3109/10837450.2012.660698. Epub 2012 Feb 21.
21. Yang L, Eshraghi J, Fassihi R. A new intragastric delivery system for the treatment of Helicobacter pylori associated gastric ulcer: in vitro evaluation J Control Release. 1999; 57 (3):215-22.
22. Mahalingam R, Jasti B, Birudaraj R, Stefanidis D, Killion R, Alfredson T, Anne P, Xiaoling Li. Evaluation of Polyethylene Oxide Compacts as Gastroretentive Delivery Systems. AAPS PharmSciTech. 2009; 10(1): 98-103
23. Chaudhary SA, Chaudhary AB, Mehta TA. Formulation development and optimization of Polyox based quick dissolving film of quetiapine, Journal of Pharmacy & Bioallied Sciences 2012; 4(1): S19-S20.
24. Kojima H, Yoshihara K, Sawada T. Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics 2008; 70:556-562.
25. Kiss D, Karoly S, Marek T. Tracking the physical aging of poly (ethylene oxide): A technical note. AAPS PharmSciTech. 2006; 7(4) Article 95.
2. http://msdssearch.dow.com/PublishedLiteratureDOWCOM/dh_0031/0901b80380031a4a.pdf?filepath=/pdfs/noreg/326-00001.pdf&fromPage=GetDoc
3. http://www.colorcon.com/literature/marketing/mr/Extended%20Release/POLYOX/English/ads_Polyox_form_peo_matrices.pdf
4. Kojima H, Yoshihara K, Sawada T. Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics 2008; 70: 556-562.
5. USP/ NF 2009 pg no. 1312
6. Chowdary KP, Deepthi KS, Rao S. Mucoadhesive Microcapsules of Indomethacin: Evaluation for Controlled Release and Ulcerogenic Activity. International Journal of Pharmaceutical Sciences and Drug Research 2009; 1(2): 74-79.
7. Yang L, Venkatesh G, Fassihi R. Characterization of compressibility and compactibility of poly (ethylene oxide) polymers for modified release application by compaction simulator. J. Pharm. Sci. 1996; 85:1085-1090.
8. Maggi L, Bruni R, Conte U. High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms. International Journal of Pharmaceutics 2000; 195: 229-238.
9. Deshkar S, Pawar M, Shirsat A, Shirolkar S. Development of sustained release tablet of Mebeverine hydrochloride. J Pharm Educ Res. 2013;4(1):64-69
10. Vidyadhara S, Sasidhar RLC, Nagaraju R. Design and Development of Polyethylene Oxide Based Matrix Tablets for Verapamil Hydrochloride. Indian J Pharm Sci.2013; 75(2):185-190.
11. Dimitrov M, Lambov N. Study of verapamil hydrochloride release from compressed hydrophilic Polyox-Wsr tablets. International Journal of Pharmaceutics. 1999; 189:105-111.
12. Kim C. Drug release from compressed hydrophilic POLYOX-WSR tablets, J. Pharm. Sci. 1995; 84: 303-306.
13. Cappello B, Del Nobile MA, La Rotonda MI, Mensitieri G, Miro A, Nicolais L. Water soluble drug delivery systems based on a non-biological bioadhesive polymeric system. Farmaco. 1994; 49(12):809-818.
14. Cappello B, De Rosa G, Giannini L, La Rotonda MI, Mensitieri G, Miro A, Quaglia F, Russo R. Cyclodextrin-containing poly (ethyleneoxide) tablets for the delivery of poorly soluble drugs: potential as buccal delivery system. Int J Pharm. 2006; 319(1-2):63-70.
15. Bukka R, Dwivedi M, Nargund LVG, Prasam K. Formulation and Evaluation of Felodipine Buccal Films containing Polyethylene Oxide. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012; 3 (3):1153-1158.
16. Di Colo G, Burgalassi S, Chetoni P. Gel-forming erodible inserts for ocular controlled delivery of ofloxacin. International Journal of Pharmaceutics. 2001; 215(1-2): 101-111.
17. http://www.colorcon.com/literature/marketing/fc/Opadry%20CA/AAPS2012_oyca_ppop_variousdrug.pdf
18. Waterman KC, Goeken G, Konagurthu S, Likar MD, MacDonald BC, Mahajan N, Swaminathan V. Osmotic capsules: A universal oral, controlled-release drug delivery dosage form. Journal of Controlled Release. 2011; 152: 264-269.
19. Jagdale SC, Bari NA, Kuchekar BS, Chabukswar AR. Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol. BioMed Research Intenational 2013; Article ID 801769, 11 pages. http://dx.doi.org/10.1155/2013/801769
20. Bomma R, Veerabrahma K. Development of gastroretentive drug delivery system for cefuroxime axetil: In vitro and in vivo evaluation in human volunteers. Pharm Dev Technol. 2013 Sep-Oct; 18(5):1230-7. doi: 10.3109/10837450.2012.660698. Epub 2012 Feb 21.
21. Yang L, Eshraghi J, Fassihi R. A new intragastric delivery system for the treatment of Helicobacter pylori associated gastric ulcer: in vitro evaluation J Control Release. 1999; 57 (3):215-22.
22. Mahalingam R, Jasti B, Birudaraj R, Stefanidis D, Killion R, Alfredson T, Anne P, Xiaoling Li. Evaluation of Polyethylene Oxide Compacts as Gastroretentive Delivery Systems. AAPS PharmSciTech. 2009; 10(1): 98-103
23. Chaudhary SA, Chaudhary AB, Mehta TA. Formulation development and optimization of Polyox based quick dissolving film of quetiapine, Journal of Pharmacy & Bioallied Sciences 2012; 4(1): S19-S20.
24. Kojima H, Yoshihara K, Sawada T. Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets. European Journal of Pharmaceutics and Biopharmaceutics 2008; 70:556-562.
25. Kiss D, Karoly S, Marek T. Tracking the physical aging of poly (ethylene oxide): A technical note. AAPS PharmSciTech. 2006; 7(4) Article 95.
Published
01-04-2014
Statistics
Abstract Display: 1084 
PDF Downloads: 1231
Dimension Badge
How to Cite
“POLYOX (POLYETHYLENE OXIDE) MULTIFUNCTIONAL POLYMER IN NOVEL DRUG DELIVERY SYSTEM”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 2, Apr. 2014, pp. 95-101, https://doi.org/10.25004/IJPSDR.2014.060203.
Issue
Section
Review Article
How to Cite
“POLYOX (POLYETHYLENE OXIDE) MULTIFUNCTIONAL POLYMER IN NOVEL DRUG DELIVERY SYSTEM”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 2, Apr. 2014, pp. 95-101, https://doi.org/10.25004/IJPSDR.2014.060203.
