EFFECT OF METHOD OF PREPARATION ON CHITOSAN MICROSPHERES OF MEFENAMIC ACID
Abstract
Mefenamic acid loaded chitosan microspheres were prepared both by thermal and gluteraldehyde cross linking methods and high level of entrapment of Mefenamic acid was obtained in gluteraldehyde cross linking method. The microspheres exhibited good swelling properties. DTA confirmed that Mefenamic acid was in solid dispersion in gluteraldehyde cross-linked chitosan microspheres. These microspheres exhibited faster release at low loading in comparison to high loading. Fitting the dissolution data of microspheres in Ritger-Peppas equation showed that at low loading the diffusional exponent (n) were high. As the polymer content increased the value of diffusional exponent approached to one, which is indicative of nearly zero order release.
Keywords:
Chitosan Microspheres, Mefenamic Acid, diffusional exponent, gluteraldehydeDOI
https://doi.org/10.25004/IJPSDR.2009.010109References
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2. Sawayanagi Y, Nambu N, Nagai T. Enhancement of dissolution properties of griseofulvin from ground mixtures with chitin and chitosan. Chem. Pharm. Bull. 1982; 30: 4464-4467.
3. Sawayanagi Y, Nambu N, Nagai T. Enhancement of dissolution properties of prednisolone from ground mixtures with chitin and chitosan. Chem. Pharm. Bull. 1983; 31: 2507-2509.
4. Poreto A, Remunan-Lopez C, Vila-Jalto JL. Effect of chitosan and chitosan glutamate enhancing the dissolution properties of poorly water soluble drug nifedipine. Int. J. Pharm. 1998. 175: 75-84.
5. Shu XZ, Zhu KJ. A novel approach to prepare tripolyphosphate/ chitosan complex beads for controlled release drug delivery. Int. J. Pharm. 2000; 201: 51-58.
6. Ganza-Gonzalez A, Anguiano-Igea S, Otero-Espinar JB. Chitosan and chondroitin microspheres for oral administration controlled release of metachlorpramide. Eur. J. Pharm. Biopharm.1999; 48:149-155.
7. Agnihotri SA, Nadagouda N, Aminabhavi TM. Recent advances on chitosan based micro and nanoparticles in drug delivery. J. Control. Release 2004; 100: 5-28.
8. Agnihotri SA, Aminabhavi TM. Controlled release of clozapine through chitosan microparticles prepared by novel method. J. Control. Release 2004; 96: 245-259.
9. Mi FL, Tan YC, Liang HF, Sung HW. In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials. 2002; 23: 181-191.
10. El-Shafy MA, Kellaway IW, Taylor G, Dickinson PA. Improved nasal bioavailability of FTIC-dextran (Mw43000) from mucoadhesive microspheres in rabbits. J. Drug Target 2000; 7: 355-361.
11. Shu XZ, Zhu KJ. Chitosan/ gelatin microsphers prepared by modified emulsification and ionotropic gelation. J. Microencapsul. 2001; 18: 237-245.
12. He P, Davis SS, Illum L. Chitosan microsphere prepared by spray drying. Int. J. Pharm. 1999; 187: 53-65.
13. Lim LY, Wan LSC. Effect of magnesium stearate on chitosan microspheres prepared by an emulsification coacervation technique. J. Microencapsul. 1998; 15: 319-333.
14. Goodman & Gilman’s. The Pharmaceutical Basis of Therapeutics, edited by Hardmen, J. G. edn. 10, Mc Graw Hill Medical Publishing Division, 1996, pp 708.
15. Dhawan S, Singla AK. Nifedipine loaded chitosan microsphere by emulsification phase separation method. Journal of Biotechnic and Histochemistr. 2003; 78(5): 243-254.
16. Theisen A, Jhmann C, Deacon MP, Harding SE. Refractive increment data-book for polymer and biomolecular scientist, Nottingham University Press, 2000, pp10.
17. Oreinti I, Aiedeh K, Gianasi E, Bertasi V, Zeechi V. Indomethacin-loaded chitosan microspheres correlation between the erosion process and release kinetics. J. Microencapsulation 1996; 13: 463-492.
18. Dodane V, Vilivalam VD. Pharmaceutical Application of Chitosan. Pharm. Sci. Tech. 1998; 1: 246-253.
19. Silverstein RM, Webster FX. Spectrometric identification of organic compounds. John Wiley & Sons. Inc., edn 6, 2003, pp 81-143.
20. Saravanan M, Bhaskar K, Srinivasa G, Dhanaraju MD. Ibuprofen-loaded ethylcellulose/ polystyrene microsphere: an approach to get prolonged drug release with reduced burst effect and low ethylcellulose content. J. Microencapsulation 2003; 20(3): 289-302.
21. Hejazi R, Amiji M. Chitosan based gastrointestinal delivery systems. J. Control. Release. 2003; 89: 51-165.
22. Lorenzo-Lamosa ML, Remunan-Lopez C, Vila-Jato JL, Alonso M J. Design of microencapsulated chitosan microspheres for colonic drug delivery. J. Control. Release 1998; 52:109-118.
23. Leung SHS, Robinson JR. The contribution of anionic polymer structural features to mucoadhesion. J. Control. Release.1988; 5: 223-231.
24. Gupta KC, Ravikumar MNV. pH dependent hydrolysis and drug release behavior of chitosan/ (polyethelene glycol) polymer network microsphere. Kulwer Academic Publishers. 2001; 753-759.
25. Bodmier S, Oh KH, Pramar Y. Preparation and evaluation of drug containing chitosan beads. Drug Delv. Ind. Pharm. 1989; 15:1475-1494.
26. Benita S, Barkai A, Pathak YV. Effect of drug loading extent on the in vitrorelease kinetic behavior of nifedipine from poly acrylate microspheres. J. Control. Release 1990; 12: 213-222.
27. Paulo C, Jose MSL. Modellining and Comparison of Dissolution profiles. Int. J. Pharm. 2001; 13: 123-133.
28. Shinkuma D, Hamaguchi T, Yamanaka Y, Mizuno N. Correlation
29. Park, S.; Choi, H. The effects of surfactants on dissolution profiles of poorly water soluble acidic drugs. Int. J. Pharm. 1984; 321: 35-41.
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01-04-2009
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“EFFECT OF METHOD OF PREPARATION ON CHITOSAN MICROSPHERES OF MEFENAMIC ACID”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 1, no. 1, Apr. 2009, pp. 36-42, https://doi.org/10.25004/IJPSDR.2009.010109.
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Copyright (c) 2009 S. Roy, G. S. Panpalia, C. B. Nandy, K. V. Rai, K. L. Tyagi, S. Dey, C. K. Meena
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
“EFFECT OF METHOD OF PREPARATION ON CHITOSAN MICROSPHERES OF MEFENAMIC ACID”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 1, no. 1, Apr. 2009, pp. 36-42, https://doi.org/10.25004/IJPSDR.2009.010109.
