EFFECTS OF MORINGA OLEIFERA, A PLANT EXTRACT CODED OBAYOKOU ON ULCERS CAUSED BY MYCOBACTERIUM ULCERANS IN CHILDREN UNDER 15 YEARS IN CÔTE D'IVOIRE
Abstract
The aqueous extract of a plant coded OBAYOKOU (Moringa oleifera ) has been tested on the healing of ulcers in children under 15 years, two lots of 15 children each were made all presenting clinical forms of Buruli ulcer. The aqueous plant extract of Moringa oleifera was added to the food supply given to Lot B (lot of experimental subjects) at a rate of 330 ml per meal per child for six weeks. Children of Lot A (control Lot) received normal diet without Moringa oleifera. The results of this study have shown that children in (lot B) in addition to the normal diet received 330 ml of Moringa oleifera per meal, had a higher rate of healing than Lot A (Witness Lot) who received only normal diet. Thus, the rate of healing of ulcers with M. oleifera (24 mm) is superior to healing without M. oleifera (10 mm) after six weeks. This study shows that we can overcome Buruli ulcer with medicinal plants that is abundantly available in Africa. It also shows that it is necessary to conduct research on a wider range of fractions of Moringa oleifera to improve the activity of antimycobacteriennes molecules in the aqueous extract of Moringa oleifera.
Keywords:
Buruli ulcer, Mycobacterium ulcerans, Moringa oleifera, Côte d'IvoireDOI
https://doi.org/10.25004/IJPSDR.2014.060211References
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7. Marion E, Deshayes C, Chauty A, Cassisa V, Tchibozo S, Cottin J, Doannio J, Marot A, Marsollier L. Détection des signatures moléculaires de Mycobacterium ulcerans chez les punaises aquatiques capturées au Benin en dehors de leur environnement aquatique. Méd. Trop. 2011; 71(2): 169-172.
8. Trebissou JND, Beourou S, Lohoues EEC, Yapi HF, Boga GL, Djaman AJ. In-vitro evaluation of the activity of aqueous extract of a plant coded Phyllam (Phyllanthus amarus) on two strains of Mycobacterum tuberculosis and one strain of Mycobacterum ulcerans. World Journal of Pharmaceutical Research 2013; 2(6): 1878-1888.
9. Trebissou JND, Djaman AJ. Epidemiological study on the mode of transmission of Buruli ulcer in Côte d’Ivoire. World Journal of Pharmaceutical Research 2013; 3(2): 1579-1584.
10. Marsollier L, Aubry A, Carbonnelle E, Canaan S, Cambeau E, Hermann JL. Mycobactérioses cutanées dues à Mycobacterium ulcerans, M. marinum, M. alscessus, M. chelonae et autres mycobactéries non tuberculeuses. EMC (Elsevier Masson SAS, Paris) Maladies infectieuses 2011; 8 : 038-F-15.
11. Kporou KE, Kra AKM, Ouattara S, Guede-Guina F, Djaman JA. Amélioration par fractionnement chromatographique de l’activité anticandidosique d’un extrait hexanique de Mitracarpus scaber Zucc. sur la croissance in vitro de Candida albicans et Candida tropicalis. Phytothérapie. 2010; 8(5): 290-294.
12. Trébissou JND, Yapi FH, Djaman JA. Pharmacological effects of MISCA F2 (Mitracarpus scaber): a Plant Extract on Intestinal Activity of Rabbit. Sch. Acad. J. Biosci. 2013; 1(6): 231-237.
13. Trébissou JND, Béourou S, Bla BK, Yapi FH, Djaman JA. Effects of Fractions of MISCA (Mitracarpus scaber), on Contractions of Rabbit Duodenum. Int. J. Curr. Microbiol. App. Sci. 2013; 2(11): 315-324.
14. Coulibaly B, N’guessan KR, Aka N, Ekaza E, N’golo DC, Trébissou N, Ouattara L, Bahi C, Coulibaly A, Assandé JM, Mohui P, Yao H, Djaman AJ et Dosso M. Activité anti-mycobactérienne in vitro des extraits de Phyllanthus amarus (Schum et Thonn) sur les souches de Mycobacterium ulcerans en Côte d’Ivoire. Bulletin de la Société Royale des Sciences de Liège. 2011; 80: 759-771.
15. Bagre I, Ouattara K, Yoro B, Meite S, Coulibaly A. Mise en évidence des propriétés antistaphylococciques des flavonoïdes totaux de Thonningia sanguinea (Vahl), une plante de la pharmacopée ivoirienne. Phytoptherapie. 2014; 10.1007/s10298-014-0835-9.
16. Ouattara B, Kra AM, Coulibaly A, Guede-Guina F. Efficacité de l’extrait éthanolique de Thonningia sanguinea sur Cryptococcus neoformans. Cahiers d’études et de recherches francophones/Santé. 2007; 17: 219-222.
17. Bolou GEK, Attioua B, N’Guessan AC, Coulibaly A, N’Guessan JD, Djaman AJ. Évaluation in-vitro de l’activité antibactérienne des extraits de Terminalia glaucescens planch. sur Salmonella typhi et Salmonella typhimurium. Bull Soc R Sci. 2011; 80: 772-790.
2. Rodhain F. hypothèses relatives au mode de transmission de Mycobacterium ulcerans. Bull. Acad. Natle Méd. 2012 ; 196 (3) : 685-690.
3. Chauty A, Ardant MF, Marsollier L, Pluschke G, Landier J, Adeye A, Goundoté A, Cottin J, Ladikpo T, Ruf T, Ji B. Oral treatment for Mycobacterium ulcerans infection: results from a pilot study in Benin. Clin. Infect. Dis. 2011; 52: 94-96.
4. Meyin S, Ebong A, Eyangoh S, Marion E, Landier J, Marsollier L, Guégan J-F, Legall P. Survey of Water Bugs in Bankim, a New Buruli Ulcer Endemic Area in Cameroon. Journal of Tropical Medicine 2012; 1238-43.
5. Landier J, Boisier P, Piam FF, Noumen-Djeunga B, Simé J, Wantong FG, Marsollier L, Fontanet A, Eyangoh S. Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon,” PLoS Neglected Tropical Diseases 2012; 5(11): 1392-2011.
6. Doannio JMC, Konan KL, Dosso FN, Koné AB, Konan YL, Sankaré, Ekaza E, Coulibaly ND, Odéhouri KP, Dosso M, Sess ED, Marsollier L et Aubry J. Micronecta sp (Corixidae) et Diplonychus sp (Belostomatidae), deux Hémiptères aquatiques hôtes et/ou vecteurs potentiels de Mycobacterium ulcerans, agent pathogène de l’ulcère de Buruli en Côte d’Ivoire. Méd Trop. 2011; 71: 53-57.
7. Marion E, Deshayes C, Chauty A, Cassisa V, Tchibozo S, Cottin J, Doannio J, Marot A, Marsollier L. Détection des signatures moléculaires de Mycobacterium ulcerans chez les punaises aquatiques capturées au Benin en dehors de leur environnement aquatique. Méd. Trop. 2011; 71(2): 169-172.
8. Trebissou JND, Beourou S, Lohoues EEC, Yapi HF, Boga GL, Djaman AJ. In-vitro evaluation of the activity of aqueous extract of a plant coded Phyllam (Phyllanthus amarus) on two strains of Mycobacterum tuberculosis and one strain of Mycobacterum ulcerans. World Journal of Pharmaceutical Research 2013; 2(6): 1878-1888.
9. Trebissou JND, Djaman AJ. Epidemiological study on the mode of transmission of Buruli ulcer in Côte d’Ivoire. World Journal of Pharmaceutical Research 2013; 3(2): 1579-1584.
10. Marsollier L, Aubry A, Carbonnelle E, Canaan S, Cambeau E, Hermann JL. Mycobactérioses cutanées dues à Mycobacterium ulcerans, M. marinum, M. alscessus, M. chelonae et autres mycobactéries non tuberculeuses. EMC (Elsevier Masson SAS, Paris) Maladies infectieuses 2011; 8 : 038-F-15.
11. Kporou KE, Kra AKM, Ouattara S, Guede-Guina F, Djaman JA. Amélioration par fractionnement chromatographique de l’activité anticandidosique d’un extrait hexanique de Mitracarpus scaber Zucc. sur la croissance in vitro de Candida albicans et Candida tropicalis. Phytothérapie. 2010; 8(5): 290-294.
12. Trébissou JND, Yapi FH, Djaman JA. Pharmacological effects of MISCA F2 (Mitracarpus scaber): a Plant Extract on Intestinal Activity of Rabbit. Sch. Acad. J. Biosci. 2013; 1(6): 231-237.
13. Trébissou JND, Béourou S, Bla BK, Yapi FH, Djaman JA. Effects of Fractions of MISCA (Mitracarpus scaber), on Contractions of Rabbit Duodenum. Int. J. Curr. Microbiol. App. Sci. 2013; 2(11): 315-324.
14. Coulibaly B, N’guessan KR, Aka N, Ekaza E, N’golo DC, Trébissou N, Ouattara L, Bahi C, Coulibaly A, Assandé JM, Mohui P, Yao H, Djaman AJ et Dosso M. Activité anti-mycobactérienne in vitro des extraits de Phyllanthus amarus (Schum et Thonn) sur les souches de Mycobacterium ulcerans en Côte d’Ivoire. Bulletin de la Société Royale des Sciences de Liège. 2011; 80: 759-771.
15. Bagre I, Ouattara K, Yoro B, Meite S, Coulibaly A. Mise en évidence des propriétés antistaphylococciques des flavonoïdes totaux de Thonningia sanguinea (Vahl), une plante de la pharmacopée ivoirienne. Phytoptherapie. 2014; 10.1007/s10298-014-0835-9.
16. Ouattara B, Kra AM, Coulibaly A, Guede-Guina F. Efficacité de l’extrait éthanolique de Thonningia sanguinea sur Cryptococcus neoformans. Cahiers d’études et de recherches francophones/Santé. 2007; 17: 219-222.
17. Bolou GEK, Attioua B, N’Guessan AC, Coulibaly A, N’Guessan JD, Djaman AJ. Évaluation in-vitro de l’activité antibactérienne des extraits de Terminalia glaucescens planch. sur Salmonella typhi et Salmonella typhimurium. Bull Soc R Sci. 2011; 80: 772-790.
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01-04-2014
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“EFFECTS OF MORINGA OLEIFERA, A PLANT EXTRACT CODED OBAYOKOU ON ULCERS CAUSED BY MYCOBACTERIUM ULCERANS IN CHILDREN UNDER 15 YEARS IN CÔTE D’IVOIRE”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 2, Apr. 2014, pp. 137-9, https://doi.org/10.25004/IJPSDR.2014.060211.
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How to Cite
“EFFECTS OF MORINGA OLEIFERA, A PLANT EXTRACT CODED OBAYOKOU ON ULCERS CAUSED BY MYCOBACTERIUM ULCERANS IN CHILDREN UNDER 15 YEARS IN CÔTE D’IVOIRE”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 6, no. 2, Apr. 2014, pp. 137-9, https://doi.org/10.25004/IJPSDR.2014.060211.
