IDENTIFICATION OF BIOACTIVE PRINCIPLES OF AVICENNIA OFFICINALIS FRUIT EXTRACT IN METHANOL AND SCREENING FOR ANTIBACTERIAL ACTIVITY
Abstract
Avicennia officinalis (AO) belongs to family Avicenniaceae. It finds a prominent place in folk medicine. Hence the present work was carried out for the identification of bioactive principles in the fruits of Avicennia officinalis and screened for the antibacterial activity against selected test cultures. The methanolic extracts has high efficacy against the test cultures. The methanolic extracts were further purified by column chromatography. With the aid of 1H NMR, 13C NMR and GC-MS analysis. The structure of the compounds were detected as Phenols namely 1, 2, 3 Benzene triol and 4, 4’-(1-methylethyldiene)bis2-methyl and both the compounds exhibited antibacterial activity. This report of ours is the first one regarding the 1, 2, 3 Benzene triol and 4, 4’-(1-methylethyldiene) bis 2-methyl in the plant Avicennia officinalis.
Keywords:
Avicennia officinalis, Fruit, Methanol, 3 Benzene triol, Phenol, 4’-(1-methylethyldiene) bis 2-methyl, Antibacterial activityDOI
https://doi.org/10.25004/IJPSDR.2015.070113References
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17. Shanmugapriya R, Ramanthan T, Renugadevi G. Phytochemical Characterization and Antimicrobial Efficiency of Mangrove Plants Avicennia marina and Avicennia officinalis. International Journal of Pharmaceutical & Biological Archives 2012; 3(2):348-351.
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25. Mohammad NS, Srinivasulu A, Satya Veni P, Rao UM. Evaluation of antioxidant activity in fruit extracts of Avicennia marina L and Avicennia officinalis L. International Journal of Pharmacy 2014; 4(3): 149-153.
2. Cowan MM. Plant products as antimicrobial agents. Clinical Microbilogy Review 1999; 12: 564-582.
3. Bandaranayake WM. Traditional and medicinal uses of mangroves. Mangroves and salt marches 1998; 2:133-148.
4. Krithikar KK, Basu BD. Indian medicinal plants, Lalit Mohan Basu Publishers, Allahabad, India, 1991; 1-4: 1-2793.
5. Satya Veni P, Sunitha S, Srinivasulu A. Evaluation of antibacterial activity on selected bacteria and screening of secondary metabolites of Avicennia Alba stem. International journal of Advanced Biotechnology and Research 2013; 4: 511-517.
6. Nkere CK, Iroegbu CU. Antibacterial screening of the root, seed and stembark extracts of Picralima nitida, African Journal of Biotechnology 2005; 4(6): 522-26.
7. Choudhury SA, Mukherjee SC, Patnaik P, Bapuji M. In vitro Antibacterial Activity of Extracts of Selected Marine Algae and Mangroves against Fish Pathogens. Asian Fisheries Science 2005; 18: 285-294.
8. Abeysinghe PD, Wanegatunge RP, Pathirana RN. Evaluation of antibacterial activity of different mangrove plant extracts. Ruhuna Journal of Science 2006; 1: 104-112.
9. Bobbarala VR, Vadlapudi, Naidu KC. Antimicrobial Potentialities of Mangrove Plant Avicennia marina. Journal of Pharmacy Research 2009; 2: 1019-1021.
10. Garcia-Salas P, Morales-Soto A, Segura-Carretero A, Fernández-Gutiérrez A. Phenolic compound- extraction systems for fruit and vegetable samples. Molecules 2010; 15: 8813–8826.
11. Doughari JH, Elmahmood AM, Mazara S. Studies on the antibacterial activity of root extracts of Carica papaya L. African Journal of Microbiology Research 2007; 1(3):37-41.
12. Mohammad NS, Srinivasulu A, Satya veni P, Rao UM. Quantification of phytochemicals and antibacterial activity of fruit extracts of AO. Asian Journal of Pharmaceutical and Clinical Research 2014; 7:127-130.
13. Bhimba BV, Meenupriya J, Joel EL, Naveena DE, Kumar S, Thangaraj M. Antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis. Asian Pacific Journal of Tropical Medicine 2010; 3(7): 544-546.
14. Subrahmanyam C, Ratna Kumar S, Damodara Reddy G. Bioactive diterpenes from mangrove Avicennia officinalis Linn. Indian J. Chemistry 2006; 45: 2556-2557.
15. Mohammad NS, Srinivasulu A, Satya Veni P, Rao UM. Quantification of phytochemicals and antibacterial activity of fruit extracts of Avicennia officinalis. Asian Journal of Pharmaceutical and Clinical Research 2014; 7(2):127-130.
16. Mitsuhiro Z, Marco W, Tokyokazu Y, Tsuyoshi S, Toru N. Purification and Characterization of Gallic acid decarboxylase from Pontoea agglomerans T71. Applied and Environmental Microbiology 1998; 64: 4743-4747.
17. Shanmugapriya R, Ramanthan T, Renugadevi G. Phytochemical Characterization and Antimicrobial Efficiency of Mangrove Plants Avicennia marina and Avicennia officinalis. International Journal of Pharmaceutical & Biological Archives 2012; 3(2):348-351.
18. Panagal M, Boominathan M. Comparative studies of the antimicrobial activity of crude extracts and fractions from Eugenia caryophullus against Candida albicans isolate from chronic disease affected patients. International journal of Pharmacy and Life Sciences 2011; 1(2): 36-47.
19. Gopalakrishnan S, Vadivel E. GC-MS analysis of some bioactive constituents of Mussaenda frondosa L. International Journal of Pharma and Bio Science 2011; 2(1): 313-320.
20. Toshitsugu T, Takashi T, Isao K. Antibacterial Spectrum of Plant Polyphenols and Extracts Depending upon Hydroxyphenyl Structure. Biol. Pharm. Bull. 2006; 29(11): 2226-2235.
21. Mahendran OR, Kreir M, Weingart H, Fertig N, Winterhalter M. Permeation of antibiotics through Escherichia coli Ompf and Ompc porins: Screening for influx on a single-molecule level. Journal of Biomolecular Screening 2010; 15 302-307.
22. Ian-Zhi L, Hiroshi N. Efflux-Mediated Drug Resistance in Bacteria: an update. Drugs. 2009; 69:1555–1623.
23. Damyanoava S, Stoyanova A. Antimocrobial activity of aromatic products 14 extracts from fruits of Sweet fennel and Coriander. Journal of essential oil bearing plants 2007; 10(5):440-445.
24. Sangeetha J, Vijayalakshmi K. Determination of bioactive components of ethyl acetate fraction of Punica granatum rind extract. International Journal of Pharmaceutical Sciences and Drug Research 2011; 3(2):116-122.
25. Mohammad NS, Srinivasulu A, Satya Veni P, Rao UM. Evaluation of antioxidant activity in fruit extracts of Avicennia marina L and Avicennia officinalis L. International Journal of Pharmacy 2014; 4(3): 149-153.
Published
01-01-2015
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“IDENTIFICATION OF BIOACTIVE PRINCIPLES OF AVICENNIA OFFICINALIS FRUIT EXTRACT IN METHANOL AND SCREENING FOR ANTIBACTERIAL ACTIVITY”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 1, Jan. 2015, pp. 73-77, https://doi.org/10.25004/IJPSDR.2015.070113.
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How to Cite
“IDENTIFICATION OF BIOACTIVE PRINCIPLES OF AVICENNIA OFFICINALIS FRUIT EXTRACT IN METHANOL AND SCREENING FOR ANTIBACTERIAL ACTIVITY”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 1, Jan. 2015, pp. 73-77, https://doi.org/10.25004/IJPSDR.2015.070113.
