Effects of pterostilbene isolated from Pterocarpus marsupium on high fat diet induced diabetic rats
Abstract
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. The present study tested the anti-diabetic and hypolipidemic potential of pterostilbene isolated from Pterocarpus marsupium plants on high fat diet-induced diabetic rats. The high-fat diet-fed rats showed increased serum glucose, cholesterol, triglycerides and insulin resistance (p < 0.05). However, treating the animals with pterostilbene different biochemical parameters like glucose tolerance, glycogen content, glucose homeostatic enzymes like glucose-6-phosphatase and hexokinase, adipocytes differentiation, and the expression profiles of different genes regulating carbohydrate and lipid metabolism were improved significantly (p < 0.05). Further, pterostilbene was found to demonstrate dual regulation activities for peroxisome proliferators-activated receptors (PPAR) (both PPARα and PPARγ). In conclusion, these results show that pterostilbene acts as a potent anti-diabetic molecule. Hence further in-depth mechanistic studies are warranted to use this phytochemical as a medicine.
Keywords:
Type-2 diabetes; serum lipid; insulin resistence; adipocytes; PPAR; Glut-4DOI
https://doi.org/10.25004/IJPSDR.2021.130614References
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