LYSOZYME HYDROCHLORIDE INHIBITS CYTOKINES IN EPITHELIAL CELLS WITH RESPIRATORY SYNCYTIAL VIRUS INFECTION: A BRIEF REPORT
Abstract
Lysozyme hydrochloride, derived from Hen Egg Lysozyme, is one of classical anti-airway inflammatory drugs. It has been widely administered in Japan, but its molecular potential is unknown. To confirm this classical drug as anti-inflammatory agent, pro-inflammatory cytokines in Epithelial Cells infected by RSV with lysozyme hydrochloride were measured. Lysozyme hydrochloride suppressed the production of IL-6, IL-1β, G-CSF although IL-8 and IFN-γ was not changed. Lysozyme hydrochloride inhibits pro-inflammatory cytokines in Epithelial cells infected with Respiratory Syncytial Virus, and may affect to airway inflammation.
Keywords:
Lysozyme hydrochloride, Respiratory Syncytial virus, IL-1β, IL-6, G-CSFDOI
https://doi.org/10.25004/IJPSDR.2015.070124References
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2. Bauer CM, Morissette MC, Stampfli MR. The influence of cigarette smoking on viral infections: translating bench science to impact COPD pathogenesis and acute exacerbations of COPD clinically. Chest 2013; 143(1):196-206.
3. Hall CB, Simoes EA, Anderson LJ. Clinical and epidemiologic features of respiratory syncytial virus. Curr Top Microbiol Immunol. 2013; 372:39-57.
4. Falsey AR. Respiratory syncytial virus infection in adults. Semin Respir Crit Care Med. 2007; 28(2):171-81.
5. Beckham JD, Cadena A, Lin J, Piedra PA, Glezen WP, Greenberg SB, Atmar RL. Respiratory viral infections in patients with chronic obstructive pulmonary disease. J Infect. 2005; 50:322-330.
6. Asada M, Yoshida M, Suzuki T, Kudo H, Yamaya M, et al. Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells. Antiviral Res. 2009; 83(2):191-200.
7. Asada M, Yoshida M, Hatachi Y, Nagatomi R, Yamaya M, et al. L-carbocisteine inhibits respiratory syncytial virus infection in human tracheal epithelial cells. Respir Physiol Neurobiol. 2012; 180(1):112-8.
8. Iesato K, Tatsumi K, Saito K, Kuriyama T, Shirasawa H, et al. Tiotropium bromide attenuates Respiratory Syncytial Virus replication in epithelial cells. Respiration 2008; 76:434-441.
9. Graham BS, Parkins MD, Wright PF, Karzon DT. Primary respiratory syncytial virus infection in mice. J Med Virol. 1988; 26:153-162.
10. Hashida S, Ishikawa E, et al. Cytokine (IL-8, IL-6, TNF-alpha) and soluble TNF receptor-I release from human peripheral blood mononuclear cells after respiratory syncytial virus infection. Immunology 1995; 85:364-372.
Published
01-01-2015
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“LYSOZYME HYDROCHLORIDE INHIBITS CYTOKINES IN EPITHELIAL CELLS WITH RESPIRATORY SYNCYTIAL VIRUS INFECTION: A BRIEF REPORT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 1, Jan. 2015, pp. 126-8, https://doi.org/10.25004/IJPSDR.2015.070124.
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How to Cite
“LYSOZYME HYDROCHLORIDE INHIBITS CYTOKINES IN EPITHELIAL CELLS WITH RESPIRATORY SYNCYTIAL VIRUS INFECTION: A BRIEF REPORT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 1, Jan. 2015, pp. 126-8, https://doi.org/10.25004/IJPSDR.2015.070124.
