A REVIEW ON THERAPEUTIC POTENTIAL OF POLYHERBAL FORMULATIONS
Abstract
Nature has been a source of medicinal agents for more than thousands of years and herbal therapy predominates in traditional systems of medicine as well as in alternative medicine practiced in various cultures such as Indian system of medicine, Chinese Traditional Medicine, Unani classical literature. The present review deals with various polyherbal formulations used by different countries of the world. Information on traditional herbal formulations was documented in the form of research and review articles in various journals. The aim of this review is to summarize the different types of herbs used for the preparation of polyherbal formulations, their therapeutic potentials including clinical and preclinical results along with their safety and efficacy. This review will facilitate to gain all about the past scientific research and the necessary information about the enormous pharmacological activities of polyherbal formulations which will insist the young researchers for future research to protect human beings from various types of diseases and may serves as a natural gold for the promotion of mankind.
Keywords:
Polyherbal, HK-07, Chooranam, Rumalaya Forte, ThapringDOI
https://doi.org/10.25004/IJPSDR.2015.070301References
1. Wills RB, Bone K, Morgan M. Herbal products: Active constituents, Modes of action and quality control. Nutr Res Rev. 2000; 13: 47-77.
2. Gohil PV, Mehta AA. Evaluation of Mast Cell Stabilizing and Anti-Anaphylactic Activity of Polyherbal Formulation. Adv Bio Res. 2011; 5(6): 304-308.
3. Gopumadhavan S, Mohamed R, Venkataranganna MV, Mitra SK. Antihistaminic and antianaphylactic activity of HK-07, a herbal Formulation. Indian J Pharmacol. 2005; 37(5): 300-303.
4. Divya K, Tripathi JS, Tiwari SK, Pandey BL. Anti-histaminic, mast cell stabilizing and bronchodilator effect of hydroalcoholic extract of polyherbal compound-Bharangyadi. Ancient Science of Life. 2012; 31(3): 95-100.
5. Bolleddula J, Nan Y, Ming-Chun W, Rong W, Joseph G, Hugh S, Xiu-Min L. Constituents of the anti-asthma herbal formula ASHMITM synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells and eotaxin by human lung fibroblasts in vitro. J Integrat Med. 2013; 11(3): 195-205.
6. Thomas M, Sheran J, Smith N, Fonseca S, Lee AJ. A botanical mixture for the treatment of asthma: A randomised, double-blind, placebo-controlled, cross-over study. BMC Pulm Med. 2007; 7: 4.
7. Wong EL, Sung RY, Leung TF, Wong YO, Li AM, Cheung KL, Wong CK, Fok TF, Leung PC. Randomized, double-blind, placebo-controlled trial of herbal therapy for children with asthma. J Altern Complement Med. 2009; 15: 1091-1097.
8. Nalini SH, Vetha MKH, Manickavasakam K, Banu G. Acute and sub acute toxicity study of a herbomineral siddha formulation thuthuvalayathy chooranam. World J Pharma Res. 2014; 3(9): 793-799.
9. Srinivasa RD, Indira AJ, Jayaraaj R. Antiasthmatic role of “Pentapala-04” an herbal formulation against ova albumin and aluminium hydroxide induced lung damage in rats. Ancient Science of Life. 2005; 14(3): 134-142.
10. AshokKumar BS, Vamshikrishna N, Saran G, Sanjay T, Dhanusha KA, Harshada R. Evaluation of In Vitro Anti-arthritic Activity of Polyherbal Formulation (Anthronav). Int. J Trad Herb Med. 2013; 1(6): 177-180.
11. Hardik S, Ghanshyam P, Megha S, Mayank P, Krishna M. Evaluation of anti-arthritic activity of Dazzle ointment-A polyherbal formulation. Int J Pharmacol Cli Sci. 2013; 2(1): 14-18.
12. Sanjay UN, Manjit S, Vinod VK, Kalyan PK, Arvind C, Namdev RK. An open label, prospective, clinical study on a polyherbal formulation in osteoarthritis of knee. J Ayur Inte Med. 2013; 4(1): 33-39.
13. Kofi D, Stephen A, Jerry A, Nutifafa T, Laud KO. Sub chronic toxicity studies of Asena, a poly-herbal formulation for the treatment of arthritis in rat. Med Aroma Plant Res J. 2014; 2(1): 18-27.
14. Subash KR, Cheriyan BV, Parvathavarthini S, Bhaarati GM, Venugopal V. Effect of polyherbal formulation rumalaya forte on adjuvant induced arthritis in rats. Indian drugs. 2012; 49(10): 18-24.
15. Rui-zhi F, Jian-qin LV, Angela KJ, Juan DM, Bing M. The efficacy and safety of Baoji Tablets for treating common cold with summer-heat and dampness syndrome: study protocol for a randomized controlled trial. Trials. 2013; 14(440): 1-8.
16. Abdul AA, Shahnawaz J, Rafat M, Aley H. Antibacterial activity of Joshanda: a polyherbal therapeutic agent used in common cold. Pakistan J Pharmacol. 2010; 27(1): 25-28.
17. Tanuja N, Bhagwat BK, Jasmin J, Narenda SB, Deepa C. J Herbal Pharmacother. 2004; 4(4): 1-12.
18. Lucia KK, Nicholas MM, Mathiu PM, Harihara MS, Festus MT, Palu D, Jennifer AO. Validation of Safety and Efficacy of Antitussive Herbal Formulations. Afr J Pharmacol Ther. 2013; 2(1): 26-31.
19. Wong WCW, Lee A, Lam AT, Li KT, Leung CYM, Leung PC, Wong ELY, Tang JL. Effectiveness of a Chinese herbal medicine preparation in the treatment of cough in uncomplicated upper respiratory tract infection: a randomised double-blinded placebo-control trial. Cough. 2006; 2(5): 1-9.
20. Eran B, Nativ D, Anat E, Moshe T, Elad S, Yoseph R. Treatment of Upper Respiratory Tract Infections in Primary Care: A Randomized Study Using Aromatic Herbs. Evidence-Based Comp Alt Med. doi:10.1155/2011/690346.
21. Rudraswamy MS, Arun, Suma H, Chaithanya MS. Efficacy of ‘Actovet-CRD’ a Novel Herbal Formulation as Prophylactic and Therapeutic Agent for CRD Complex in Poultry. J World’s Poult Res. 2013; 3(2): 57-62.
22. Krishnamoorthy JR, Ranjith MS, Gokulshankar S, Mohanty BK, Sumithra R, Ranganathan S, Babu K. An Overview of Management of URTI and a Novel Approach Towards RSV Infection. Respiratory Diseases. 179-194.
23. Mohamed R, Gollapalle LV, Dattatray AS, Mohammed A, Mahalingaiah J, Krishna D, Pralhad SP. Poly-Ingredient Formulation Bresol® Ameliorates Experimental Chronic Obstructive Pulmonary Disease (COPD) in Rats. Scientia Pharmaceutica. 2013; 81: 833-842.
24. Kyung-Hwa J, Kyoung-Keun H, Soojin P, Youngeun K, Seung RL, Geunhyeog L, Miran K, Moochang H, Minkyu S, Sungki J, Hyunsu B. The standardized herbal formula, PM014, ameliorated cigarette smoke-induced lung inflammation in a murine model of chronic obstructive pulmonary disease. BMC Compl Alt Med. 2013; 13: 219-229.
25. Hyojung L, Youngeun K, Hye JK, Soojin P, Young PJ, Sungki J, Heejae J, Hyunsu B. Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Compl Alt Med. doi:10.1155/2012/769830.
26. Joseph TFL, Leung PC, Wong ELY, Fong C, Cheng KF, Zhang SC, Lam CWK, Wong V, Choy KM, Ko WM. The Use of an Herbal Formula by Hospital Care Workers During the Severe Acute Respiratory Syndrome Epidemic in Hong Kong to Prevent Severe Acute Respiratory Syndrome Transmission, Relieve Influenza-Related Symptoms, and Improve Quality of Life: A Prospective Cohort Study. J Alt Compl Med. 2005; 11(1): 49-55.
27. Chui SH, Shek SL, Fong MY, Szeto YT, Chan K. A panel study to evaluate quality of life assessments in patients suffering from allergic rhinitis after treatment with a Chinese herbal nasal drop. Phytother Res. 2010; 24: 609-613.
28. Kalpana S, Kolhapure SA. Evaluation of efficacy and safety of Bresol (HK-07) tablets in upper and lower respiratory tract allergic diseases in children. Medicine Update. 2004; 12(3): 37-46.
29. Corren J, Lemay M, Lin Y, Rozga L, Randolph RK. Clinical and biochemical effects of a combination botanical product (clearguard) for allergy: A pilot randomized double-blind placebo-controlled trial. Nutr J. 2008; 7: 20.
30. Zhao Y, Leung PC, Woo KS, Chen GG, Wong YO, Wang LH. The effect and therapeutic mechanism of a Chinese herbal formula shi-bi-lin (SBL) in the treatment of allergic rhinitis-animal study and in vitro study. J Aller Clin Immunol. 2005; 115: 139.
31. Tariq S, Asim AL, Arun M, Mohd A, Manzar A, Fasihuzzaman. Evaluation of the clinical efficacy of a poly herbal Unani formulation in Warm-e-shoab muzmin (chronic bronchitis). International Journal of Advances in Pharmacy Medicine and Bioallied Sciences. 2014; 2(1): 46-48.
32. Goto FA, Ogawa KY. Sho-saiko-to-ka-kikyo-sekko as an alternative treatment for chronic tonsillitis to avoid surgery. Complement. Ther Clin Pract. 2010; 16: 216-218.
33. Prakash T, Kala SK. Koflet Lozenges in the Treatment of Sore Throat. The Antiseptic. 2001; 9(4): 124-127.
34. Yong C, Rong S, Huijiang S, Meili S, Tian S, Mina S, Kenneth K, Pingping G, Tuong N, Jianyu R. Effects of Lung Support Formula on respiratory symptoms among older adults: results of a three-month follow-up study in Shanghai, China. Nutrition Journal. 2013; 12(57); 1-7.
35. Padmanabha RA, Kaiser J. Preclinical Evaluation of Polyherbal Formulations: Hypoglycemic Activity in Rats. Int J Ayur Herb Med. 2012; 2(2): 218-228.
36. Vinod SB, Bhusari GS. Effect of madhumeh an antibiotic polyherbal formulation on carbohydrate metabolism and antioxidant defence in Streptozotocin-Nicotinamide (STZ-NICO) induced diabetic rats. Int J Pharm Life Sci. 2012; 3(5): 1690-1695.
37. David RC, Jayanthi V, Manaswini VS, Gayathri R, Ranjani C, Brindha P. Effect of polyherbal formulation (ob-6) on high fat diet induced hyperlipidemia in rats. Int J Pharm Pharmaceut Sci. 2012; 4(2): 31-35.
38. Muhammad SA, Mamoona Z, Hafiz MI, Sajid B. Hypoglycemic effect of a compound herbal formulation (ziabeen) on blood glucose in normal and alloxan-diabetic rabbits. Diabetologia Croatica. 2012; 41(3): 87-94.
39. Parasuraman S, Kumar EP, Anil K, Emerson SF. Antihyperlipidemic effect of triglize, a polyherbal formulation. Int J Pharm Pharmaceut Sci. 2010; 2(3): 118-122.
40. Krishanu S, Atmatrana TM, Manikeswar KR, Kadainti VSS, Alluri VK, Golakoti T. Efficacy and tolerability of a novel herbal formulation for weight management in obese subjects: a randomized double blind placebo controlled clinical study. Lipids Health Dis. 2012; 11: 1-10.
41. Mitra SK, Sundaram R, Venkataranganna MV, Gopumadhavan S. Pharmacokinetic Interaction of Diabecon (D-400) with Rifampicin and Nifedipine. Eur J Drug Metabol Pharmacokinetics. 1999; 24(1): 79-82.
42. Amodu B, Itodo SE, Musa DE. Evaluation of SAAAB as a Polyherbal Formulation for the Treatment of Ataxia. J Pharm Biol Sci. 2014; 9(3): 26-28.
43. Baldi A, Goyal S. Hypoglycemic Effect of Polyherbal Formulation in Alloxan Induced Diabetic Rats. Pharmacologyonline. 2011; 3: 764-773.
44. Sruthi TD, Satyavati K, Upendar C, Pradeep K. Antidiabetic activity and anti-oxidant activity of niddwin, a polyherbal formulation in alloxan induced diabetic rats. Int J Pharm Pharmaceut Sci. 2014; 6(2): 273-277.
45. Patrick-Iwuanyanwu KC, Amadi U, Charles IA, Ayalogu EO. Evaluation of acute and sub-chronic oral toxicity study of baker cleansers bitters-a polyherbal drug on experimental rats. EXCLI Journal. 2012; 11: 632-640.
46. Evan PS, Mahaboob KR, Lazar M. In vivo and in vitro immunomodulatory effects of Indian ayurvedic herbal formulation triphala on experimental induced inflammation. Pharmacologyonline. 2009; 2: 840-849.
47. Mohammed A, Koteshwar P, Licto T, Jagadish VK. Evaluation of Analgesics and Anti-Inflammatory Activiyt of Sudard, A Poly-Herbal Formulation. Iran J Pharmacol Ther. 2007; 6(1): 71-75.
48. Karina CPM, Juliana CM, Margareth FFMD, Isac AM, Bagnolia AS, Marcia RP. Effect of the activity of the Brazilian polyherbal formulation: Eucalyptus globulus Labill, Peltodon radicans Pohl and Schinus terebinthifolius Radd in inflammatory models. Braz J Pharmacog. 2007; 17(1): 23-28.
49. Rabish C, Kumarappan CT, Jyoti K, Manda SC. Antipyretic Activity of JURU-01-a Polyherbal Formulation. Global J Pharmacol. 2010; 4(1): 45-47.
50. Ogbonnia SO, Mbaka GO, Emordi J, Nkemhule F, Joshua P, Usman A, Odusanya P, Ota D. Antimicrobial evaluation and acute and sub-acute toxicity studies on a commercial polyherbal formulation, “Ade & Ade Antidiabetic®” used in the treatment of diabetes in southwestern Nigerian. J Medicine and Medical Sci. 2013; 4(11): 423-432,
51. Jyothi MJ, Praveen K, Mohanalakshmi S, Prathyusha S. Formulation and evaluation of poly herbal hand wash. Int J Pharm. 2012; 2(2): 39-43.
52. Meher A, Mohapatra TK, Nayak RR, Pradhan AR, Agrahari AK, Mohapatra TR, Ghosh MK. Antitussive evaluation of formulated polyherbal cough syrup. J Drug Del Thera. 2012; 2(5): 61-64.
53. Emmanuel EH, Mainen JM, Ramadhani SON, Dennis TM, Rogasian LAM. A study of antimicrobial activity, acute toxicity and cytoprotective effect of a polyherbal extract in a rat ethanol-HCl gastric ulcer model. BMC Res. Notes. 2012; 5: 546.
54. Abdul L, Mohd BT, Abdur R, Asad UK, Sumbu R. Laooq Sapistan Khyaar Shambari. A Unani Herbal Formulation. Int J Pharma Res Bio-sci. 2013; 2(5): 67-77.
55. Rajasree PH, Vidya V, Merin C, Jincy E, Ranjith S. Formulation and evaluation of antiseptic polyherbal ointment. Int J Pharma Life Sci. 2012; 3(10): 2021-2031.
56. Bhawana S, Hemlata S, Prakash CB. Formulation and Antioxidant Evaluation of Ayurvedic Poly Herbal Preparation (Avaleha). Int J Pharma Sci Rev Res. 2013; 20(1): 43-46.
57. Stefano C, Mariateresa P, Anna RC, Alfonso B. Antioxidant Potential of the Polyherbal Formulation ‘‘ImmuPlus’’. A Nutritional Supplement for Horses. Vet Med Int. doi.org/10.1155/2014/434239.
58. Yuvarani S, Radhika J, Jothi G, Sangeetha D. Antioxidant effect of a herbal formulation in paracetamol induced toxicity in albino rats. World J Pharm Pharmaceut Sci. 2014; 3(5): 1024-1031.
59. Inder KM, Aswatha R, Shreedhara CS, Vijay KS, Raviraj D. In vitro antioxidant studies of Sitopaladi Churna, a polyherbal Ayurvedic formulation. Free Radicals and Antioxidants. 2011; 1(2): 37-41.
60. Divya KK, Mayank G, Amit KS, Yamini BT, Jyoti ST, Shrikant T. Evaluation of in vitro antioxidant capacity and reducing potential of polyherbal drug Bharagyadi. Ancient Sci Life. 2012; 32(1): 24-28.
61. Anju D, Iswar H, Jaikumar S. Antidepressant activity of a polyherbal formulation R013, in experimental animal model. Int J Phytopharm. 2014; 5(4): 267-271.
62. Achliya GS, Wadodkar SG, Dorle AK. Evaluation of CNS activity of Bramhi Ghrita. Indian J Pharmacol. 2005; 37(1): 33-36.
63. Sarang J, Ameeta A. Evaluation of Diuretic Potential of A Polyherbal Formulation. J Nat Prod Plant Resour. 2012; 2(3): 368-371.
64. Un-Ho J, Dong-Il K, Tae-Kyun L, Dong-Nyung L, June-Ki K, In-Seon L, Cheorl-Ho K. Herbal formulation, Yukmi-jihang-tang-Jahage, regulates bone resorption by inhibition of phosphorylation mediated by tyrosine kinase Src and cyclooxygenase expression. J Ethnopharm. 2006; 106: 333-343.
65. Sheela SC, Shyamala DCS. Protective Effect of Abana, a Poly-herbal Formulation, on Isoproterenol-induced Myocardial Infarction in Rats. Indian J Pharmacol. 2000; 32: 198-201.
66. Anoop A, Elsie CS, Thirugnanasambantham P. Evaluating the clinical efficacy of a polyherbal formulation Arogh plus on stress-a randomised clinical study. J Stress Physio Biochem. 201; 7(1): 66-78.
67. Tenzin C, Dawa D, Vijay K. Pro-apoptotic and anticancer properties of Thapring-A Tibetan herbal formulation. J Ethnopharmacol. 2011; 137: 320-326.
68. Mangaiarkarasi A, Imtiaz NL, Anil BK, Paul S, Gayathri M, Praveen KK, Bhuthiah S, Eugene W, Savariraj S, Gopinath V, Rajalakshmi P, Karthikeyan B, Devanathan R, Ravichandran M, Mariamma P, Ravindra KC, Jeelan NB, Pushpak M, Gurvinder K, Narinder KM, Tapas KK, Subbakrishna DK, Kadappa SS, Udaykumar R. Evident stabilization of the clinical profile in HIV/AIDS as evaluated in an open label clinical trial using a polyherbal formulation. Indian J Med Res. 2013; 137: 1128-1144.
69. Shukla GN, Mahender N, Kala SK. Use of PR-2000, a Herbal Formulation in the Medical Management of Benign Prostatic Hyperplasia. Indian J Cli Prac. 2002; 13(2): 53-56.
70. Sangeetha DP, Banumathi V, Jayasree S. Acute and subacute toxicity study on amirtha sanjeevi kuligai. World J Pharm Res. 2014; 3(8): 778-787.
71. Venkataranganna MV, Gopumadhavan S, Sundaram R, Ghouse P, Mitra SK. Pharmacodynamics and toxicological profile of PartySmart, a herbal preparation for alcohol hangover in Wistar rats. Indian J Med Res. 2008; 127: 460-466.
72. Raghunatha RKR, Vinaya BSN, Raghavendra N, Vinod VK, Sanjay UN. Acute and 28-day repeated dose toxicity studies with polyherbal formulation of isabgol husk, swarnapatri leaf extract and triphala fruits extract (tlpl/ay/01/2008). Int J Pharm Bio Sci. 2011; 2(4): 639-652.
73. Santanu G, Singh DP, Mandal KD, Suresh K. Evaluation of safety and efficacy of a Polyherbal formulation Liv.52 DS in the Management of Non-Alcoholic Steatohepatitis (NASH): An open clinical study. Int J Current Res Academic Rev. 2014; 2(9): 305-316.
74. In SS, Mee YL, Yongbum K, Chang SS, Jung HK, Hyeun KS. Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague-Dawley Rats. BMC Comp Alt Med. 2012; 12(266): 1-10.
75. Muhammad UT, Aftab S, Ejaz M, Khan U, Halima N, Allah N, Irshad A, Faheem AS. Comparative clinical evaluation on herbal formulation Pepsil, Safoof-e-Katira and Omeprazole in gastro esophageal reflux disease. Pak J Pharm Sci. 2015; 28(3): 863-870.
76. Chia-Hung L, Ching-Hua Y, Li-Jen L, Shulhn-Der W, Jen-Shu W, Shung-Te K. Immunomodulatory Effect of Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang in Lipopolysaccharide-Induced Acute Lung Injury Mice. Evidence-Based Comp Alt Med. 2013; 1-13.
77. Balaji G, Ramesh B, Mahendranath G, Jagadeesh K, Venu B. Protective effects of a poly herbal formulation against aspirin induced ulcers in wistar rats. Int J Pharm Pharmaceut Sci. 2012; 4(l5): 190-194.
78. Hanumantharayappa B, Madhava RPV, Mahantesh A. Preclinical Studies of Exher, a Polyherbal Preparation for Uterine Tonic Activity. Int J Pharm Sci Inven. 2014; 3(5): 33-38.
2. Gohil PV, Mehta AA. Evaluation of Mast Cell Stabilizing and Anti-Anaphylactic Activity of Polyherbal Formulation. Adv Bio Res. 2011; 5(6): 304-308.
3. Gopumadhavan S, Mohamed R, Venkataranganna MV, Mitra SK. Antihistaminic and antianaphylactic activity of HK-07, a herbal Formulation. Indian J Pharmacol. 2005; 37(5): 300-303.
4. Divya K, Tripathi JS, Tiwari SK, Pandey BL. Anti-histaminic, mast cell stabilizing and bronchodilator effect of hydroalcoholic extract of polyherbal compound-Bharangyadi. Ancient Science of Life. 2012; 31(3): 95-100.
5. Bolleddula J, Nan Y, Ming-Chun W, Rong W, Joseph G, Hugh S, Xiu-Min L. Constituents of the anti-asthma herbal formula ASHMITM synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells and eotaxin by human lung fibroblasts in vitro. J Integrat Med. 2013; 11(3): 195-205.
6. Thomas M, Sheran J, Smith N, Fonseca S, Lee AJ. A botanical mixture for the treatment of asthma: A randomised, double-blind, placebo-controlled, cross-over study. BMC Pulm Med. 2007; 7: 4.
7. Wong EL, Sung RY, Leung TF, Wong YO, Li AM, Cheung KL, Wong CK, Fok TF, Leung PC. Randomized, double-blind, placebo-controlled trial of herbal therapy for children with asthma. J Altern Complement Med. 2009; 15: 1091-1097.
8. Nalini SH, Vetha MKH, Manickavasakam K, Banu G. Acute and sub acute toxicity study of a herbomineral siddha formulation thuthuvalayathy chooranam. World J Pharma Res. 2014; 3(9): 793-799.
9. Srinivasa RD, Indira AJ, Jayaraaj R. Antiasthmatic role of “Pentapala-04” an herbal formulation against ova albumin and aluminium hydroxide induced lung damage in rats. Ancient Science of Life. 2005; 14(3): 134-142.
10. AshokKumar BS, Vamshikrishna N, Saran G, Sanjay T, Dhanusha KA, Harshada R. Evaluation of In Vitro Anti-arthritic Activity of Polyherbal Formulation (Anthronav). Int. J Trad Herb Med. 2013; 1(6): 177-180.
11. Hardik S, Ghanshyam P, Megha S, Mayank P, Krishna M. Evaluation of anti-arthritic activity of Dazzle ointment-A polyherbal formulation. Int J Pharmacol Cli Sci. 2013; 2(1): 14-18.
12. Sanjay UN, Manjit S, Vinod VK, Kalyan PK, Arvind C, Namdev RK. An open label, prospective, clinical study on a polyherbal formulation in osteoarthritis of knee. J Ayur Inte Med. 2013; 4(1): 33-39.
13. Kofi D, Stephen A, Jerry A, Nutifafa T, Laud KO. Sub chronic toxicity studies of Asena, a poly-herbal formulation for the treatment of arthritis in rat. Med Aroma Plant Res J. 2014; 2(1): 18-27.
14. Subash KR, Cheriyan BV, Parvathavarthini S, Bhaarati GM, Venugopal V. Effect of polyherbal formulation rumalaya forte on adjuvant induced arthritis in rats. Indian drugs. 2012; 49(10): 18-24.
15. Rui-zhi F, Jian-qin LV, Angela KJ, Juan DM, Bing M. The efficacy and safety of Baoji Tablets for treating common cold with summer-heat and dampness syndrome: study protocol for a randomized controlled trial. Trials. 2013; 14(440): 1-8.
16. Abdul AA, Shahnawaz J, Rafat M, Aley H. Antibacterial activity of Joshanda: a polyherbal therapeutic agent used in common cold. Pakistan J Pharmacol. 2010; 27(1): 25-28.
17. Tanuja N, Bhagwat BK, Jasmin J, Narenda SB, Deepa C. J Herbal Pharmacother. 2004; 4(4): 1-12.
18. Lucia KK, Nicholas MM, Mathiu PM, Harihara MS, Festus MT, Palu D, Jennifer AO. Validation of Safety and Efficacy of Antitussive Herbal Formulations. Afr J Pharmacol Ther. 2013; 2(1): 26-31.
19. Wong WCW, Lee A, Lam AT, Li KT, Leung CYM, Leung PC, Wong ELY, Tang JL. Effectiveness of a Chinese herbal medicine preparation in the treatment of cough in uncomplicated upper respiratory tract infection: a randomised double-blinded placebo-control trial. Cough. 2006; 2(5): 1-9.
20. Eran B, Nativ D, Anat E, Moshe T, Elad S, Yoseph R. Treatment of Upper Respiratory Tract Infections in Primary Care: A Randomized Study Using Aromatic Herbs. Evidence-Based Comp Alt Med. doi:10.1155/2011/690346.
21. Rudraswamy MS, Arun, Suma H, Chaithanya MS. Efficacy of ‘Actovet-CRD’ a Novel Herbal Formulation as Prophylactic and Therapeutic Agent for CRD Complex in Poultry. J World’s Poult Res. 2013; 3(2): 57-62.
22. Krishnamoorthy JR, Ranjith MS, Gokulshankar S, Mohanty BK, Sumithra R, Ranganathan S, Babu K. An Overview of Management of URTI and a Novel Approach Towards RSV Infection. Respiratory Diseases. 179-194.
23. Mohamed R, Gollapalle LV, Dattatray AS, Mohammed A, Mahalingaiah J, Krishna D, Pralhad SP. Poly-Ingredient Formulation Bresol® Ameliorates Experimental Chronic Obstructive Pulmonary Disease (COPD) in Rats. Scientia Pharmaceutica. 2013; 81: 833-842.
24. Kyung-Hwa J, Kyoung-Keun H, Soojin P, Youngeun K, Seung RL, Geunhyeog L, Miran K, Moochang H, Minkyu S, Sungki J, Hyunsu B. The standardized herbal formula, PM014, ameliorated cigarette smoke-induced lung inflammation in a murine model of chronic obstructive pulmonary disease. BMC Compl Alt Med. 2013; 13: 219-229.
25. Hyojung L, Youngeun K, Hye JK, Soojin P, Young PJ, Sungki J, Heejae J, Hyunsu B. Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Compl Alt Med. doi:10.1155/2012/769830.
26. Joseph TFL, Leung PC, Wong ELY, Fong C, Cheng KF, Zhang SC, Lam CWK, Wong V, Choy KM, Ko WM. The Use of an Herbal Formula by Hospital Care Workers During the Severe Acute Respiratory Syndrome Epidemic in Hong Kong to Prevent Severe Acute Respiratory Syndrome Transmission, Relieve Influenza-Related Symptoms, and Improve Quality of Life: A Prospective Cohort Study. J Alt Compl Med. 2005; 11(1): 49-55.
27. Chui SH, Shek SL, Fong MY, Szeto YT, Chan K. A panel study to evaluate quality of life assessments in patients suffering from allergic rhinitis after treatment with a Chinese herbal nasal drop. Phytother Res. 2010; 24: 609-613.
28. Kalpana S, Kolhapure SA. Evaluation of efficacy and safety of Bresol (HK-07) tablets in upper and lower respiratory tract allergic diseases in children. Medicine Update. 2004; 12(3): 37-46.
29. Corren J, Lemay M, Lin Y, Rozga L, Randolph RK. Clinical and biochemical effects of a combination botanical product (clearguard) for allergy: A pilot randomized double-blind placebo-controlled trial. Nutr J. 2008; 7: 20.
30. Zhao Y, Leung PC, Woo KS, Chen GG, Wong YO, Wang LH. The effect and therapeutic mechanism of a Chinese herbal formula shi-bi-lin (SBL) in the treatment of allergic rhinitis-animal study and in vitro study. J Aller Clin Immunol. 2005; 115: 139.
31. Tariq S, Asim AL, Arun M, Mohd A, Manzar A, Fasihuzzaman. Evaluation of the clinical efficacy of a poly herbal Unani formulation in Warm-e-shoab muzmin (chronic bronchitis). International Journal of Advances in Pharmacy Medicine and Bioallied Sciences. 2014; 2(1): 46-48.
32. Goto FA, Ogawa KY. Sho-saiko-to-ka-kikyo-sekko as an alternative treatment for chronic tonsillitis to avoid surgery. Complement. Ther Clin Pract. 2010; 16: 216-218.
33. Prakash T, Kala SK. Koflet Lozenges in the Treatment of Sore Throat. The Antiseptic. 2001; 9(4): 124-127.
34. Yong C, Rong S, Huijiang S, Meili S, Tian S, Mina S, Kenneth K, Pingping G, Tuong N, Jianyu R. Effects of Lung Support Formula on respiratory symptoms among older adults: results of a three-month follow-up study in Shanghai, China. Nutrition Journal. 2013; 12(57); 1-7.
35. Padmanabha RA, Kaiser J. Preclinical Evaluation of Polyherbal Formulations: Hypoglycemic Activity in Rats. Int J Ayur Herb Med. 2012; 2(2): 218-228.
36. Vinod SB, Bhusari GS. Effect of madhumeh an antibiotic polyherbal formulation on carbohydrate metabolism and antioxidant defence in Streptozotocin-Nicotinamide (STZ-NICO) induced diabetic rats. Int J Pharm Life Sci. 2012; 3(5): 1690-1695.
37. David RC, Jayanthi V, Manaswini VS, Gayathri R, Ranjani C, Brindha P. Effect of polyherbal formulation (ob-6) on high fat diet induced hyperlipidemia in rats. Int J Pharm Pharmaceut Sci. 2012; 4(2): 31-35.
38. Muhammad SA, Mamoona Z, Hafiz MI, Sajid B. Hypoglycemic effect of a compound herbal formulation (ziabeen) on blood glucose in normal and alloxan-diabetic rabbits. Diabetologia Croatica. 2012; 41(3): 87-94.
39. Parasuraman S, Kumar EP, Anil K, Emerson SF. Antihyperlipidemic effect of triglize, a polyherbal formulation. Int J Pharm Pharmaceut Sci. 2010; 2(3): 118-122.
40. Krishanu S, Atmatrana TM, Manikeswar KR, Kadainti VSS, Alluri VK, Golakoti T. Efficacy and tolerability of a novel herbal formulation for weight management in obese subjects: a randomized double blind placebo controlled clinical study. Lipids Health Dis. 2012; 11: 1-10.
41. Mitra SK, Sundaram R, Venkataranganna MV, Gopumadhavan S. Pharmacokinetic Interaction of Diabecon (D-400) with Rifampicin and Nifedipine. Eur J Drug Metabol Pharmacokinetics. 1999; 24(1): 79-82.
42. Amodu B, Itodo SE, Musa DE. Evaluation of SAAAB as a Polyherbal Formulation for the Treatment of Ataxia. J Pharm Biol Sci. 2014; 9(3): 26-28.
43. Baldi A, Goyal S. Hypoglycemic Effect of Polyherbal Formulation in Alloxan Induced Diabetic Rats. Pharmacologyonline. 2011; 3: 764-773.
44. Sruthi TD, Satyavati K, Upendar C, Pradeep K. Antidiabetic activity and anti-oxidant activity of niddwin, a polyherbal formulation in alloxan induced diabetic rats. Int J Pharm Pharmaceut Sci. 2014; 6(2): 273-277.
45. Patrick-Iwuanyanwu KC, Amadi U, Charles IA, Ayalogu EO. Evaluation of acute and sub-chronic oral toxicity study of baker cleansers bitters-a polyherbal drug on experimental rats. EXCLI Journal. 2012; 11: 632-640.
46. Evan PS, Mahaboob KR, Lazar M. In vivo and in vitro immunomodulatory effects of Indian ayurvedic herbal formulation triphala on experimental induced inflammation. Pharmacologyonline. 2009; 2: 840-849.
47. Mohammed A, Koteshwar P, Licto T, Jagadish VK. Evaluation of Analgesics and Anti-Inflammatory Activiyt of Sudard, A Poly-Herbal Formulation. Iran J Pharmacol Ther. 2007; 6(1): 71-75.
48. Karina CPM, Juliana CM, Margareth FFMD, Isac AM, Bagnolia AS, Marcia RP. Effect of the activity of the Brazilian polyherbal formulation: Eucalyptus globulus Labill, Peltodon radicans Pohl and Schinus terebinthifolius Radd in inflammatory models. Braz J Pharmacog. 2007; 17(1): 23-28.
49. Rabish C, Kumarappan CT, Jyoti K, Manda SC. Antipyretic Activity of JURU-01-a Polyherbal Formulation. Global J Pharmacol. 2010; 4(1): 45-47.
50. Ogbonnia SO, Mbaka GO, Emordi J, Nkemhule F, Joshua P, Usman A, Odusanya P, Ota D. Antimicrobial evaluation and acute and sub-acute toxicity studies on a commercial polyherbal formulation, “Ade & Ade Antidiabetic®” used in the treatment of diabetes in southwestern Nigerian. J Medicine and Medical Sci. 2013; 4(11): 423-432,
51. Jyothi MJ, Praveen K, Mohanalakshmi S, Prathyusha S. Formulation and evaluation of poly herbal hand wash. Int J Pharm. 2012; 2(2): 39-43.
52. Meher A, Mohapatra TK, Nayak RR, Pradhan AR, Agrahari AK, Mohapatra TR, Ghosh MK. Antitussive evaluation of formulated polyherbal cough syrup. J Drug Del Thera. 2012; 2(5): 61-64.
53. Emmanuel EH, Mainen JM, Ramadhani SON, Dennis TM, Rogasian LAM. A study of antimicrobial activity, acute toxicity and cytoprotective effect of a polyherbal extract in a rat ethanol-HCl gastric ulcer model. BMC Res. Notes. 2012; 5: 546.
54. Abdul L, Mohd BT, Abdur R, Asad UK, Sumbu R. Laooq Sapistan Khyaar Shambari. A Unani Herbal Formulation. Int J Pharma Res Bio-sci. 2013; 2(5): 67-77.
55. Rajasree PH, Vidya V, Merin C, Jincy E, Ranjith S. Formulation and evaluation of antiseptic polyherbal ointment. Int J Pharma Life Sci. 2012; 3(10): 2021-2031.
56. Bhawana S, Hemlata S, Prakash CB. Formulation and Antioxidant Evaluation of Ayurvedic Poly Herbal Preparation (Avaleha). Int J Pharma Sci Rev Res. 2013; 20(1): 43-46.
57. Stefano C, Mariateresa P, Anna RC, Alfonso B. Antioxidant Potential of the Polyherbal Formulation ‘‘ImmuPlus’’. A Nutritional Supplement for Horses. Vet Med Int. doi.org/10.1155/2014/434239.
58. Yuvarani S, Radhika J, Jothi G, Sangeetha D. Antioxidant effect of a herbal formulation in paracetamol induced toxicity in albino rats. World J Pharm Pharmaceut Sci. 2014; 3(5): 1024-1031.
59. Inder KM, Aswatha R, Shreedhara CS, Vijay KS, Raviraj D. In vitro antioxidant studies of Sitopaladi Churna, a polyherbal Ayurvedic formulation. Free Radicals and Antioxidants. 2011; 1(2): 37-41.
60. Divya KK, Mayank G, Amit KS, Yamini BT, Jyoti ST, Shrikant T. Evaluation of in vitro antioxidant capacity and reducing potential of polyherbal drug Bharagyadi. Ancient Sci Life. 2012; 32(1): 24-28.
61. Anju D, Iswar H, Jaikumar S. Antidepressant activity of a polyherbal formulation R013, in experimental animal model. Int J Phytopharm. 2014; 5(4): 267-271.
62. Achliya GS, Wadodkar SG, Dorle AK. Evaluation of CNS activity of Bramhi Ghrita. Indian J Pharmacol. 2005; 37(1): 33-36.
63. Sarang J, Ameeta A. Evaluation of Diuretic Potential of A Polyherbal Formulation. J Nat Prod Plant Resour. 2012; 2(3): 368-371.
64. Un-Ho J, Dong-Il K, Tae-Kyun L, Dong-Nyung L, June-Ki K, In-Seon L, Cheorl-Ho K. Herbal formulation, Yukmi-jihang-tang-Jahage, regulates bone resorption by inhibition of phosphorylation mediated by tyrosine kinase Src and cyclooxygenase expression. J Ethnopharm. 2006; 106: 333-343.
65. Sheela SC, Shyamala DCS. Protective Effect of Abana, a Poly-herbal Formulation, on Isoproterenol-induced Myocardial Infarction in Rats. Indian J Pharmacol. 2000; 32: 198-201.
66. Anoop A, Elsie CS, Thirugnanasambantham P. Evaluating the clinical efficacy of a polyherbal formulation Arogh plus on stress-a randomised clinical study. J Stress Physio Biochem. 201; 7(1): 66-78.
67. Tenzin C, Dawa D, Vijay K. Pro-apoptotic and anticancer properties of Thapring-A Tibetan herbal formulation. J Ethnopharmacol. 2011; 137: 320-326.
68. Mangaiarkarasi A, Imtiaz NL, Anil BK, Paul S, Gayathri M, Praveen KK, Bhuthiah S, Eugene W, Savariraj S, Gopinath V, Rajalakshmi P, Karthikeyan B, Devanathan R, Ravichandran M, Mariamma P, Ravindra KC, Jeelan NB, Pushpak M, Gurvinder K, Narinder KM, Tapas KK, Subbakrishna DK, Kadappa SS, Udaykumar R. Evident stabilization of the clinical profile in HIV/AIDS as evaluated in an open label clinical trial using a polyherbal formulation. Indian J Med Res. 2013; 137: 1128-1144.
69. Shukla GN, Mahender N, Kala SK. Use of PR-2000, a Herbal Formulation in the Medical Management of Benign Prostatic Hyperplasia. Indian J Cli Prac. 2002; 13(2): 53-56.
70. Sangeetha DP, Banumathi V, Jayasree S. Acute and subacute toxicity study on amirtha sanjeevi kuligai. World J Pharm Res. 2014; 3(8): 778-787.
71. Venkataranganna MV, Gopumadhavan S, Sundaram R, Ghouse P, Mitra SK. Pharmacodynamics and toxicological profile of PartySmart, a herbal preparation for alcohol hangover in Wistar rats. Indian J Med Res. 2008; 127: 460-466.
72. Raghunatha RKR, Vinaya BSN, Raghavendra N, Vinod VK, Sanjay UN. Acute and 28-day repeated dose toxicity studies with polyherbal formulation of isabgol husk, swarnapatri leaf extract and triphala fruits extract (tlpl/ay/01/2008). Int J Pharm Bio Sci. 2011; 2(4): 639-652.
73. Santanu G, Singh DP, Mandal KD, Suresh K. Evaluation of safety and efficacy of a Polyherbal formulation Liv.52 DS in the Management of Non-Alcoholic Steatohepatitis (NASH): An open clinical study. Int J Current Res Academic Rev. 2014; 2(9): 305-316.
74. In SS, Mee YL, Yongbum K, Chang SS, Jung HK, Hyeun KS. Subacute toxicity and stability of Soshiho-tang, a traditional herbal formula, in Sprague-Dawley Rats. BMC Comp Alt Med. 2012; 12(266): 1-10.
75. Muhammad UT, Aftab S, Ejaz M, Khan U, Halima N, Allah N, Irshad A, Faheem AS. Comparative clinical evaluation on herbal formulation Pepsil, Safoof-e-Katira and Omeprazole in gastro esophageal reflux disease. Pak J Pharm Sci. 2015; 28(3): 863-870.
76. Chia-Hung L, Ching-Hua Y, Li-Jen L, Shulhn-Der W, Jen-Shu W, Shung-Te K. Immunomodulatory Effect of Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang in Lipopolysaccharide-Induced Acute Lung Injury Mice. Evidence-Based Comp Alt Med. 2013; 1-13.
77. Balaji G, Ramesh B, Mahendranath G, Jagadeesh K, Venu B. Protective effects of a poly herbal formulation against aspirin induced ulcers in wistar rats. Int J Pharm Pharmaceut Sci. 2012; 4(l5): 190-194.
78. Hanumantharayappa B, Madhava RPV, Mahantesh A. Preclinical Studies of Exher, a Polyherbal Preparation for Uterine Tonic Activity. Int J Pharm Sci Inven. 2014; 3(5): 33-38.
Published
01-05-2015
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“A REVIEW ON THERAPEUTIC POTENTIAL OF POLYHERBAL FORMULATIONS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 3, May 2015, pp. 211-28, https://doi.org/10.25004/IJPSDR.2015.070301.
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How to Cite
“A REVIEW ON THERAPEUTIC POTENTIAL OF POLYHERBAL FORMULATIONS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 3, May 2015, pp. 211-28, https://doi.org/10.25004/IJPSDR.2015.070301.
