EVALUATION OF MEMORY ENHANCING ACTIVITY OF LEAF EXTRACT OF DALBERGIA SISSOO IN MICE
Abstract
Dalbergia sissoo (family: Fabaceae) is an Asian deciduous rosewood tree. It is the state tree of Punjab state (India) called as Shisham used for antipyretic, emesis, ulcers, leucoderma, stomach troubles and skin disease, memory enhancer etc. The aim of this study is to evaluate the learning and memory activity of ethanolic leaf extracts of Dalbergia sissoo in mice. The animals were divided into six groups of 6 each. Group I was considered as normal control, II as Standard control (Imipramine), III, IV and V was treated group (ELDS 300, 450 and 600 mg/kg respectively) and VI as scopolamine treated (negative control).The effect of ethanolic leaf extract of Dalbergia sissoo was investigated in mice for memory enhancing activity using various experimental paradigms of learning and memory viz. Transfer latency (TL) on elevated plus maze and passive avoidance. For memory and learning activity vehicle/ extracts / STD drug administered daily for first seven days, on 8th day dementia was induced by scopolamine. ELDS significantly enhanced the learning and memory activities against the scopolamine induced dementia and significant decrease in Acetylcholinesterase level in brain in animals. The memory enhanced activity as evidenced by learning and retrieval was due to cholinergic facilitatory effect in animals. These results indicate a possible memory enhancing action of Dalbergia sissoo which qualitatively comparable with that of piracetam.
Keywords:
Dalbergia sissoo, Scopolamine, Acetylcholinestrase, Elevated plus maze, ELDSDOI
https://doi.org/10.25004/IJPSDR.2015.070307References
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