DHAWA (WOODFORDIA FRUTICOSA (L.) KURZ.): A VERSATILE MEDICINAL PLANT
Abstract
Woodfordia fruticosa is an important medicinal plant used in traditional system of medicine since the time immemorial. It belongs to the family Lythraceae. Many organic constituents like tannins, phenols, steroids/terpenoids, carbohydrates, resins and inorganic ones including iron, aluminum, calcium, magnesium, potassium etc., have been isolated from this species in recent times. Extracts and metabolites of this plant, particularly those from flowers and leaves, possess useful pharmacological activities. Flowers are qabiz (astringent), mubarrid (refrigerant), habisud dam (haemostatic), qatil kirme shikam (anthelminthic), mujaffif (dessicative), mundamil qurooh (enhance wound healing) musakkin atsh, musaffi khoon etc. It is commonly used to cure ishaal (diarrhoea), kasrate tams (menorrhagia), and bawaseer damvia (bleeding piles). Aabzan (sitz bath) with decoction of this drug is useful for khuroojul miqad (prolapse of anus) and sailanur rehem (leucorrhoea). The bark is also pungent, acrid, cooling, toxic, alexatric, antihelmintic, antidysentric, and uterine sedative. The bark is used in thirst, dysentery, leprosy, erysipelas and diseases of the blood. Antitumor, DNA inhibitory, immunomodulatory, antioxidant, aniproliferative, antihyperglycemic, anti-inflammatory, analgesic, cytotoxic, antibacterial, hepatoprotective, antimicrobial and anti-ulcer activities were found in various parts of this plant. Ethnopharmacological activities, chemical component and related pharmacological effects reveal that the plant Woodfordia fruticosa is an important medicinal plant having versatile beneficial pharmacological effects.
Keywords:
Lythraceae, Pharmacological studies, Phenols, Steroids/terpenoids, Traditional medicine, Woodfordia fruticosaDOI
https://doi.org/10.25004/IJPSDR.2015.070402References
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9. Deshpande DJ. A Handbook of Herbal Remedies 1st edition, Agrobios Publications, Jodhpur, 2011, pp. 129-30.
10. Khare CP. Indian Medicinal Plant: An Illustrated Dictionary. 1st edition, Raj Kamal Electric Press, New Delhi, 2007, pp.718.
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13. Anonymous. Standardization of Single Drugs of Unani Medicine. Part 2, Central Council of Research in Unani Medicine, New Delhi, 1987, pp. 126-131.
14. Nabi MG. Makhzan Mufradat wa Murakkabat. Central Council of Research in Unani Medicine, New Delhi, 2007, pp. 49, 56, 204, 219.
15. Hakeem MAH. Mufradat Azeezi. Central Council of Research in Unani Medicine, New Delhi, 2009, pp.83.
16. Anonymous. Medicinal Plants in Folklores of Northern India. Central Council of Research in Unani Medicine, New Delhi, 2009, pp. 76, 113-114, 517.
17. Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants. Vol-1, Central Drug Research Institute, Lucknow, 1999, pp. 14, 61, 67, 276, 710.
18. Weersaooriya MK, Yatawara HP. Purification and Properties of Invertase from the Flowers of Woodfordia fruticosa. Indian J Biochem Biophys. 2002; 39(5):347-50.
19. Finose A, Devaki K. Phytochemical and Chromatographic Studies in the Flowers of Woodfordia fruticosa (L) kurz. Asian Journal of Plant Science and Research 2011; 1 (3): 81-85.
20. Mishra P, Mishra D, Awasthi A, Arnold R. Physio-Chemical Analysis and Chemo-Profiling of Ayurvedic Single Drugs of Herbal Origin-Woodfordia fruticosa (Linn.) Kurz. Science Secure Journals 2013; 2 (1):16-21.
21. Lal UR, Tripathi SM, Jachak SM, Bhutani KK, Singh IP. HPLC Analysis and Standardization of Arjunarishta-An Ayurvedic Cardioprotective Formulation. Scientia Pharmaceutica 2009; 77 (3):605.
22. Kuramochi-Motegi A, Kuramochi H, Kobayashi F, Ekimoto H, Takahashi K, Kadota S, Takamori Y, Kikuchi T. Woodfruticosin (woodfordin C), a New Inhibitor of DNA to Poisomerase II. Experimental Antitumor Activity. Biochem Pharmacol. 1992; 44(10):1961-5.
23. Yoshida T, Chou T, Haba K, Okano Y, Shingu T, Miyamoto K, Koshiura R, Okuda T. Camelliin B, and Nobotanin I, Macrocyclic Ellagitannin Dimers and Related Dimers, and their Antitumor Activity. Chem Pharm Bull. 1989; 37(11):3174-6.
24. Yoshida T, Chou T, Matsuda M, Yasuhara T, Yazaki K, Hatano T, Nitta A, Okuda T. Woodfordin D and Oenothein A, Trimeric Hydrolyzable Tannins of Macroring Structure with Antitumor Activity. Chem Pharm Bull 1991; 39(5):1157-62.
25. Kadota S, Takamori Y, Nyein KN, Kikuchi T, Tanaka K, Ekimoto H. Constituents of the Leaves of Woodfordia fruticosa Kurz. Isolation, Structure, and Proton and Carbon-13 Nuclear Magnetic Resonance Signal Assignments of Woodfruticosin (Woodfordin C), An Inhibitor of Deoxyribonucleic Acid Topoisomerase II. Chem Pharm Bull 1990; 38(10):2687-97.
26. Shah AS, Juvekar AR. In vitro and in-vivo Immunostimulatory Activity of Woodfordia fruticosa Flowers on Non-specific Immunity. Pharm Biol. 2010; 48(9):1066-72.
27. Nitha A, Ansil PN, Prabha SP, Wills PJ, Latha MS. Preventive and Curative Effect of Woodfordia fruticosa Kurz Flowers on Thioacetamide Induced Oxidative Stress in Rats. Asian Pacific Journal of Tropical Biomedicine 2012; S757-S764.
28. Nitha A, Prabha SP, Ansil PN, Latha MS. Antiproliferative Effect of Woodfordia fruticosa Kurz. Flowers on Experimentally Induced Hepatocellular Carcinoma in Rats and in Human Hepatoma Cell Line. Journal of Pharmacy Research 2013; 6(2): 239-248.
29. Verma N, Amresh G, Sahu PK, Rao ChV, Singh AP. Antihyperglycemic Activity of Woodfordia fruticosa (Kurz) Flowers Extracts in Glucose Metabolism and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats. Indian J Exp Biol 2012; 50(5):351-8.
30. Ghante MH, Bhusari KP, Duragkar NJ, Jain NS, Warokar AS. Broncho-protective, Bronchodilatory and Anti-Inflammatory Activity of Ethanolic Extract from Woodfordia fruticosa (Kurz.) Flowers. Indian Journal of Pharmaceutical Education and Research 2012; 46(2):168-73.
31. Baravalia Y, Vaghasiya Y, Chanda S. Brine Shrimp Cytotoxicity, Anti-inflammatory and Analgesic Properties of Woodfordia fruticosa Kurz Flowers. Iranian Journal of Pharmaceutical Research 2012; 11(3): 851-861.
32. Kumaraswamy MV, Kavitha HU, Satish S. Antibacterial Potential of Extracts of Woodferdia fruticosa Kurtz. on Human Pathogens. World Journal of Medical Sciences 2008; 3(2):93-96.
33. Dabur R, Gupta A, Lavekar GS. Antimicrobial Activity of Some Indian Medicinal Plants. Afr J Tradit Complement Altern Med. 2007; 4(3): 313–318.
34. Dubey D, Sahu MC, Rath S, Paty BP, Debata NK, Padhy RN. Antimicrobial Activity of Medicinal Plants Used by Aborigines of Kalahandi, Orissa, India against Multidrug Resistant Bacteria. Asian Pacific Journal of Tropical Biomedicine 2012; S846-S854.
35. Baravalia Y, Vaghasiya Y, Chanda S. Hepatoprotective Effect of Woodfordia fruticosa Kurtz. Flower on Diclofenac Sodium Induced Liver Toxicity in Rats. Asian Pac J Trop Med. 2011; 4(5):342-6.
36. Mihira V, Ramana KV, Ramakrishna S, Rambabu P. Evaluation of Anti-Ulcer Activity of Woodfordia fruticosa Roots. Pharmanest 2011; 2(2-3):158-60.
2. Charters ML. Fruticosa: California Plant Names: Latin and Greek Meanings and Derivations. A Dictionary of Botanical and Biographical Etymology. Available at URL: http://www.calflora.net/botanicalnames/pageF.html [Accessed on 21-11-13].
3. Woodfordia fruticosa. IUCN Read List of Threatened Species. Available at URL: http://www.iucnredlist.org/search [Accessed on 21-11-2013].
4. Woodfordia fruticosa. Global Biodiversity information Facility. Available at URL: http://www.gbif.org/species/6708992 [Accessed on 21-11-13].
5. Woodfordia fruticosa (L.) Kurz. Medicinal Plants of Bangladesh. Available at http://www.mpbd.info/plants/woodfordia-fruticosa.php
6. Pullaiah T. Encyclopedia of world medicinal plants, Vol.1, Regency publications, New Delhi, 2006, pp. 97, 339, 1350-51, 2072.
7. Taxon: Woodfordia fruticosa (L.)Kurz. Available at [URL:http://www.arsgrin.gov/cgibin/npgs/html/taxon.pl42056 [Accessed on 22-11-2013].
8. Das PK, Goswami S, Chinniah A, Panda N, Banerjee S, Sahu NP, Achari B. Woodfordia fruticosa: Traditional uses and recent findings. Journal of Ethnopharmacology 2007; 110(2):189-199.
9. Deshpande DJ. A Handbook of Herbal Remedies 1st edition, Agrobios Publications, Jodhpur, 2011, pp. 129-30.
10. Khare CP. Indian Medicinal Plant: An Illustrated Dictionary. 1st edition, Raj Kamal Electric Press, New Delhi, 2007, pp.718.
11. Kirtikar KR, Basu BD. Indian Medicinal Plants with Illustrations. Vol.7, Oriental Enterprises, Dehradun, 2003, pp. 489-92, 3514-19, 1496-99.
12. Ghani N. Khazainul Advia. Vol. 1st, Idara Kitab ul Shifa, New Delhi, 1971. pp. 700, 701.
13. Anonymous. Standardization of Single Drugs of Unani Medicine. Part 2, Central Council of Research in Unani Medicine, New Delhi, 1987, pp. 126-131.
14. Nabi MG. Makhzan Mufradat wa Murakkabat. Central Council of Research in Unani Medicine, New Delhi, 2007, pp. 49, 56, 204, 219.
15. Hakeem MAH. Mufradat Azeezi. Central Council of Research in Unani Medicine, New Delhi, 2009, pp.83.
16. Anonymous. Medicinal Plants in Folklores of Northern India. Central Council of Research in Unani Medicine, New Delhi, 2009, pp. 76, 113-114, 517.
17. Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants. Vol-1, Central Drug Research Institute, Lucknow, 1999, pp. 14, 61, 67, 276, 710.
18. Weersaooriya MK, Yatawara HP. Purification and Properties of Invertase from the Flowers of Woodfordia fruticosa. Indian J Biochem Biophys. 2002; 39(5):347-50.
19. Finose A, Devaki K. Phytochemical and Chromatographic Studies in the Flowers of Woodfordia fruticosa (L) kurz. Asian Journal of Plant Science and Research 2011; 1 (3): 81-85.
20. Mishra P, Mishra D, Awasthi A, Arnold R. Physio-Chemical Analysis and Chemo-Profiling of Ayurvedic Single Drugs of Herbal Origin-Woodfordia fruticosa (Linn.) Kurz. Science Secure Journals 2013; 2 (1):16-21.
21. Lal UR, Tripathi SM, Jachak SM, Bhutani KK, Singh IP. HPLC Analysis and Standardization of Arjunarishta-An Ayurvedic Cardioprotective Formulation. Scientia Pharmaceutica 2009; 77 (3):605.
22. Kuramochi-Motegi A, Kuramochi H, Kobayashi F, Ekimoto H, Takahashi K, Kadota S, Takamori Y, Kikuchi T. Woodfruticosin (woodfordin C), a New Inhibitor of DNA to Poisomerase II. Experimental Antitumor Activity. Biochem Pharmacol. 1992; 44(10):1961-5.
23. Yoshida T, Chou T, Haba K, Okano Y, Shingu T, Miyamoto K, Koshiura R, Okuda T. Camelliin B, and Nobotanin I, Macrocyclic Ellagitannin Dimers and Related Dimers, and their Antitumor Activity. Chem Pharm Bull. 1989; 37(11):3174-6.
24. Yoshida T, Chou T, Matsuda M, Yasuhara T, Yazaki K, Hatano T, Nitta A, Okuda T. Woodfordin D and Oenothein A, Trimeric Hydrolyzable Tannins of Macroring Structure with Antitumor Activity. Chem Pharm Bull 1991; 39(5):1157-62.
25. Kadota S, Takamori Y, Nyein KN, Kikuchi T, Tanaka K, Ekimoto H. Constituents of the Leaves of Woodfordia fruticosa Kurz. Isolation, Structure, and Proton and Carbon-13 Nuclear Magnetic Resonance Signal Assignments of Woodfruticosin (Woodfordin C), An Inhibitor of Deoxyribonucleic Acid Topoisomerase II. Chem Pharm Bull 1990; 38(10):2687-97.
26. Shah AS, Juvekar AR. In vitro and in-vivo Immunostimulatory Activity of Woodfordia fruticosa Flowers on Non-specific Immunity. Pharm Biol. 2010; 48(9):1066-72.
27. Nitha A, Ansil PN, Prabha SP, Wills PJ, Latha MS. Preventive and Curative Effect of Woodfordia fruticosa Kurz Flowers on Thioacetamide Induced Oxidative Stress in Rats. Asian Pacific Journal of Tropical Biomedicine 2012; S757-S764.
28. Nitha A, Prabha SP, Ansil PN, Latha MS. Antiproliferative Effect of Woodfordia fruticosa Kurz. Flowers on Experimentally Induced Hepatocellular Carcinoma in Rats and in Human Hepatoma Cell Line. Journal of Pharmacy Research 2013; 6(2): 239-248.
29. Verma N, Amresh G, Sahu PK, Rao ChV, Singh AP. Antihyperglycemic Activity of Woodfordia fruticosa (Kurz) Flowers Extracts in Glucose Metabolism and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats. Indian J Exp Biol 2012; 50(5):351-8.
30. Ghante MH, Bhusari KP, Duragkar NJ, Jain NS, Warokar AS. Broncho-protective, Bronchodilatory and Anti-Inflammatory Activity of Ethanolic Extract from Woodfordia fruticosa (Kurz.) Flowers. Indian Journal of Pharmaceutical Education and Research 2012; 46(2):168-73.
31. Baravalia Y, Vaghasiya Y, Chanda S. Brine Shrimp Cytotoxicity, Anti-inflammatory and Analgesic Properties of Woodfordia fruticosa Kurz Flowers. Iranian Journal of Pharmaceutical Research 2012; 11(3): 851-861.
32. Kumaraswamy MV, Kavitha HU, Satish S. Antibacterial Potential of Extracts of Woodferdia fruticosa Kurtz. on Human Pathogens. World Journal of Medical Sciences 2008; 3(2):93-96.
33. Dabur R, Gupta A, Lavekar GS. Antimicrobial Activity of Some Indian Medicinal Plants. Afr J Tradit Complement Altern Med. 2007; 4(3): 313–318.
34. Dubey D, Sahu MC, Rath S, Paty BP, Debata NK, Padhy RN. Antimicrobial Activity of Medicinal Plants Used by Aborigines of Kalahandi, Orissa, India against Multidrug Resistant Bacteria. Asian Pacific Journal of Tropical Biomedicine 2012; S846-S854.
35. Baravalia Y, Vaghasiya Y, Chanda S. Hepatoprotective Effect of Woodfordia fruticosa Kurtz. Flower on Diclofenac Sodium Induced Liver Toxicity in Rats. Asian Pac J Trop Med. 2011; 4(5):342-6.
36. Mihira V, Ramana KV, Ramakrishna S, Rambabu P. Evaluation of Anti-Ulcer Activity of Woodfordia fruticosa Roots. Pharmanest 2011; 2(2-3):158-60.
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01-07-2015
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“DHAWA (WOODFORDIA FRUTICOSA (L.) KURZ.): A VERSATILE MEDICINAL PLANT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 4, July 2015, pp. 315-20, https://doi.org/10.25004/IJPSDR.2015.070402.
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How to Cite
“DHAWA (WOODFORDIA FRUTICOSA (L.) KURZ.): A VERSATILE MEDICINAL PLANT”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 7, no. 4, July 2015, pp. 315-20, https://doi.org/10.25004/IJPSDR.2015.070402.
