SPRAY DRYING: A APPROACH FOR SOLUBILITY ENHANCEMENT OF RITONAVIR BY SOLID DISPERSION
Abstract
The aim of present work was to improve the dissolution rate of Ritonavir by preparing micro-particles with certain hydrophilic polymers via spray drying technique. Role of spray drying method was studied for solubility enhancement of poorly aqueous soluble model Ritonavir using solid dispersion approach. All the carriers showed dissolution improvement vis-à-vis pure drug in varying degrees. The solid dispersions were characterized in comparison with pure drug and corresponding Physical mixture (PM). The prepared solid dispersion were evaluated by drug content analysis, saturation solubility, DSC (Differential scanning calorimeter), SEM (Scanning electron microscopy), PXRD (Powder X-ray diffraction), FTIR (Fourier transform infrared spectroscopy).and in vitro drug release. Absence of pure drug peaks in PXRD suggests transformation of crystalline drug into an amorphous form. The transformation of Ritonavir from crystalline to amorphous state by spray drying and the hydrophilic coating of drug particles by the polymers are considered for improvement of Solubility and dissolution of Ritonavir.
Keywords:
Spray Drying, Solubility Enhancement, Ritonavir, Solid DispersionDOI
https://doi.org/10.25004/IJPSDR.2015.070403References
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Copyright (c) 2015 G. S. Karva, V. R. Katariya, S. R. Shahi
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