FORMULATION DEVELOPMENT AND OPTIMIZATION OF OLMESARTAN MEDOXOMIL IMMEDIATE RELEASE TABLETS
Abstract
Olmesartan Medoxomil blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor. ACE inhibitor is used in treatment of hypertension. The objective of the present study was to formulate an immediate release tablet of an antihypertensive drug, Olmesartan Medoxomil. Pre-formulation studies were carried out and results were within the limits. Tablets of Olmesartan Medoxomil were initially prepared by direct compression approach which resulted in poor flowability of the blend. Then the tablets were prepared by wet granulation techniques and the dissolution observed was on lower side. To obtain the desired dissolution pattern various trials had been taken with different excipients. Tablets were evaluated for their weight, hardness, friability, drug content, in-vitro dissolution. Similarity and dissimilarity factor were also calculated for Olmesartan Medoxomil with reference tablet. Stability study indicates that the formulation was stable.
Keywords:
Olmesartan Medoxomil, Preformulation studies, Solubility study, Multimedia dissolution, Stability studyDOI
https://doi.org/10.25004/IJPSDR.2015.070503References
2. Patel HP, Karwa P, Bukka R, Patel NJ. Formulation and Evaluation of Immediate Release Tablets of Zolpidem Tartrate by Direct Compression. International Journal of Pharmaceutical Sciences Review and Research 2011; 7(2):80-85.
3. Panchal DM, Tiwari AK. A Research on Improvisation in Dissolution of Olmesartan Medoxomil by Enhancing its Solubility Using Solid Dispersion Techniques. World Journal of Pharmaceutical Research 2013; 2(5): 1793-1816.
4. Lavande JP, Ade RN, Jaiswal SB, Chandewar AV. Evaluation and Optimization of Olmesartan Medoxomil tablet using Synthetic and Natural superdisintegrants. Int. J. Pure App. Biosci. 2013; 1(5):19-29.
5. Abdul Hasan SA, Jaya LJ. Enhancement of Solubility and Dissolution Rate of Olmesartan Medoxomil by Solid Dispersion Technique. J. Curr. Chem. Pharm. Sc. 2013; 3(2):123-134.
6. Compressed Preparation European Patent Application published in accordance with Art. 153, (4) EPC patent no: EP 2 033 643 A1.
7. Sruthy PN, Anoop KR. Formulation and Evaluation of Olmesartan Medoxomil Floating Tablets. Int J Pharm Pharm Sci. 2013; 5(3): 691-696.
8. Sasidhar RLC, Vidyadhara S, Maheswari GV, Deepti B, Srinivasa Babu P. Solubility and Dissolution Rate Enhancement of Olmesartan Medoxomil by Complexation and Development of Mouth Dissolving Tablets. Advances in Biological Research 2013; 7(2): 32-41.
9. Prudhvi RV, Subhashis D, Maleswari T, Niranjan BM, Bhaskar NB. Preparation, Characterization and Evaluation of Olmesartan Medoxomil-Β Cyclodextrin Complexes, Indian Journal of Research in Pharmacy and Biotechnology 2013; 1(3):420-427.
Published
Abstract Display: 873 
PDF Downloads: 980 
