POSSIBLE PHARMACOLOGICAL BASIS FOR ANTITHROMBOTIC EFFECT OF GLYCYRRHIZA GLABRA IN SPRAGUE DAWLEY RATS

Authors

  • M. Jain CDRI, Lucknow, India
  • A. Yadav BITS, Pilani, Rajasthan, India
  • V. Tomar Intitute of Professional Studies, Shivpuri Link Road, Gwalior-474002 M.P. India
  • P. Kannojia Intitute of Professional Studies, Shivpuri Link Road, Gwalior-474002 M.P. India
  • S. S. Solanki Intitute of Professional Studies, Shivpuri Link Road, Gwalior-474002 M.P. India
  • S. D. Tonpay G. R. Medical College, Department of Pharmacology, Gwalior-474002 M.P., India

Abstract

It has been previously identified that 3-aryl comarin derivative, GU-7 isolated from Liquorice posses Antiplatelet activity. It inhibits platelet aggregation by increasing intraplatelet cyclic AMP concentration. Here we report the in-vivo effects of extract of Glycyrrhiza glabra and also the combined effect with Vitamin K and Heparin. Extract of Glycyrrhiza glabraincreased the bleeding time when given in the doses of 180 mg/kg and 360 mg/kg. Blood loss was evaluated 60 minute later as a function of absorbance at 540 nm due to hemoglobin content in water solution. Altogether data indicates that Glycyrrhiza glabra is an effective anti thrombotic agent in vivo, which may account for its known pharmacological properties. 

Keywords:

Glycyrrhiza glabra, Thrombin, Venous thrombosis, Rats.

DOI

https://doi.org/10.25004/IJPSDR.2009.010213

References

Tawada M, Yada Y. Anti platelet action of GU-7, a 3 arylcoumarin derivative, purified from glycyrrhizae radix. Planta Medica 1990; 56(2):259-263.

Becker RC. Understanding the dynamics of thrombin in cardiovascular disease. Pathobiology and biochemistry for the clinician. American Heart Journal 2005; 149(1): 2-8.

Gurm HS, Bhatt DL. Thrombin, an ideal target for pharmacological inhibition. A review of direct thrombin inhibitors. American Heart Journal 2005; 149(3): 43-53.

Bode W, Stubbs MT. Spatial structure of thrombin as a guide to its multiple sites of interaction. Seminars in thrombosis and hemostasis Journal 1993; 19(4): 321-33.

Baba M, Shigeta ES. Antiviral activity of glycyrrhizin against varicella-zoster virus in vitro. Antiviral Research Journal 1987; 7(2): 99-107.

Published

01-07-2009
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How to Cite

“POSSIBLE PHARMACOLOGICAL BASIS FOR ANTITHROMBOTIC EFFECT OF GLYCYRRHIZA GLABRA IN SPRAGUE DAWLEY RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 1, no. 2, July 2009, pp. 113-5, https://doi.org/10.25004/IJPSDR.2009.010213.

Issue

Volume 1, Issue 2, 2009

Section

Research Article

Copyright (c) 2009 M. Jain, A. Yadav, V. Tomar, P. Kannojia, S. S. Solanki, S. D. Tonpay

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

“POSSIBLE PHARMACOLOGICAL BASIS FOR ANTITHROMBOTIC EFFECT OF GLYCYRRHIZA GLABRA IN SPRAGUE DAWLEY RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 1, no. 2, July 2009, pp. 113-5, https://doi.org/10.25004/IJPSDR.2009.010213.

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