ANTI-ULCER EFFECT OF CHENOPODIUM ALBUM LINN. AGAINST GASTRIC ULCERS IN RATS
Abstract
The effect of alcoholic extract of Chenopodium album Linn. (Chenopodiaceae) was investigated in rats to evaluate the anti-ulcer activity by using three models, i.e., pyloric ligation, ethanol and cold restraint stress induced ulcers. Ranitidine was used as reference standard. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, pH, free acidity, total acidity and ulcer index. The results indicate that the alcoholic extract significantly decreases the volume of gastric acid secretion, free acidity, total acidity and ulcer index with respect to control. Sections of ulcerated area revealed that there was a significant increase in regenerated glandular epithelium width after treatment with the alcohol extract. The collagen content in the ulcerated tissue was significantly increased by alcohol extract and ranitidine, showing the maximum effect. No significant difference on capillary density in scar tissue was observed after treatment with alcohol extract or ranitidine.
Keywords:
Chenopodium album Linn., anti-ulcer activity, pylorus ligation model, ethanol induced ulcer, cold restraint stress, ulcer index.DOI
https://doi.org/10.25004/IJPSDR.2011.030409References
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17. Jhade D, Padmaa MP, Usha G. Isolation of phytoconstituents from the leaves of Chenopodium album Linn. J of Pharmacy Rese. 2009; 2 (7):1192-1193.
18. Dai Y, Ye WC, Wang ZT, Mastuda H, Kubo M, But PP. Antiprurutic and antinociceptive effect of Chenopodium album L in mice. J Ethnopharmacol.2002; 81(2): 245-50.
19. Jabbar A, Zaman MA, Labal Z, Yaseen M, Shamin A. Anthelmintic activity of Chenopodium album L and Caesalpinia crista L against trichostrongylid nematodes of sheep. J Ethnopharmacol. 2007; 114 (1): 86-91.
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2. Repetto MG, Llesuy SF. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res. 2002; 35: 523-534.
3. Peckenpaugh NJ, Poleman CM. Nutricao: Essencia Dietoterapia, 7th ed, SaoPaulo, Roca, 1997.
4. Available on world wide web: http://ayurvedicmedicinalplants.com/plants/3174.html(Cited on 2009 Sep 24)
5. Nedialkova ZK, Nedialkov PT, Nikolov SD. The genus Chenopodium: Phytochemistry, Ethno pharmacology and Pharmacology. Phcog Rev. 2009; 3(6): 280-306.
6. Anonymous. The Wealth of India (Raw Materials), Vol. 3. Publication and Information Directorate, CSIR, New Delhi, 2001, pp.464-469.
7. Warrier PK. Indian Medicinal Plants- A Compendium of 500 Species. Vol. 2. Orient Longman Pvt Ltd, Chennai, 2001, pp.61-62.
8. Agarwal SS, Yamrekar BP, Paridhavi M. Clinical Useful Herbal Drug. Ahuja Publishing House, New Delhi, 2005, pp.10-12.
9. Panda H. Handbook on Medicinal Herbs with Uses. Asia Pacific Business Press, New Delhi, 2005, pp.325-326.
10. Pramila K, Neetu S, Anju R. Medicinal plants used in traditional health care system prevalent in Western Himalaya. Indian J Traditional Knowle. 2006; 5(3): 300-309.
11. Khare CP. Indian Medicinal Plants. Springer International Publication, New Delhi, 2007, pp.141-142.
12. Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants. Vol. 3. reprint edn. CDRI, Lucknow, 1998, pp.162-163.
13. Della Greca M, D’Abrosca B, Fiorentino A, Previtera H, Zarrelli A. Structure elucidation and phytotoxicity of ecdysteroids from Chenopodium album. Chem Biodivers. 2005; 2(4): 457-62.
14. Della Greca M, Di Marino C, Zarrelli A, D’Abrosca B. Isolation and phytotoxicity of apocarotenoids from Chenopodium album. J Nat Prod. 2004; 67(9): 1492-5.
15. Cutillo F, D’Abrosca B, Della Greca M, Zarrelli A. Chenoalbicin, a novel cinnamic acid amide alkaloid from Chenopodium album. Chem Biodivers.2004; 1(10): 1579-83.
16. Cutillo F, Della Greca M, Gionti M, Previtera H, Zarrelli A. Phenol and lignans from Chenopodium album. Phytochemical Anal.2006; 17 (5): 344-9.
17. Jhade D, Padmaa MP, Usha G. Isolation of phytoconstituents from the leaves of Chenopodium album Linn. J of Pharmacy Rese. 2009; 2 (7):1192-1193.
18. Dai Y, Ye WC, Wang ZT, Mastuda H, Kubo M, But PP. Antiprurutic and antinociceptive effect of Chenopodium album L in mice. J Ethnopharmacol.2002; 81(2): 245-50.
19. Jabbar A, Zaman MA, Labal Z, Yaseen M, Shamin A. Anthelmintic activity of Chenopodium album L and Caesalpinia crista L against trichostrongylid nematodes of sheep. J Ethnopharmacol. 2007; 114 (1): 86-91.
20. Kumar S, Biswas S, Mandal D, Roy HN, Chakraborty S, Kabir SN. Chenopodium album seed extract: a potent sperm immobilizing agent both in vivo and in vitro. Contraception. 2007; 75(1): 71-8.
21. Rastogi L, Patnaik GK, Dikshit M. Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats. Pharmacol Res.1998; 38:125-132
22. Gupta SK. Drug Screening Methods. Jaypee Brothers Medical Publishers, New Delhi, 2005, pp.175-176.
23. Pihan G, Regillo C, Szabo S. Free radicals and lipid peroxidation in ethanol- aspirin-induced gastric mucosal injury. Dig Dis and Sci.1987; 32: 1395-1401.
24. Khare S, Asad M, Dhamanigi SS, Satya Prasad V. Antiulcer activity of cod liver oil in rats. Ind J Pharmacol. 2008; 40(5): 209-214.
25. Vogel WH, Scholkens BA, Sandow J, Muller G. Drug Discovery and Evaluation; Pharmacological Assay. Second ed. Springer-Verlag, Berlin, 2002, pp.906-944.
Published
01-10-2011
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“ANTI-ULCER EFFECT OF CHENOPODIUM ALBUM LINN. AGAINST GASTRIC ULCERS IN RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 4, Oct. 2011, pp. 319-22, https://doi.org/10.25004/IJPSDR.2011.030409.
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How to Cite
“ANTI-ULCER EFFECT OF CHENOPODIUM ALBUM LINN. AGAINST GASTRIC ULCERS IN RATS”. International Journal of Pharmaceutical Sciences and Drug Research, vol. 3, no. 4, Oct. 2011, pp. 319-22, https://doi.org/10.25004/IJPSDR.2011.030409.
