Quality Audit and Anti-Inflammatory Activity of Marketed Formulations of Ashokarishta Syrup and Chandraprabha Vati
Abstract
Herbal formulations play an important role in medicines; however, their suboptimal standardization, in terms of identity, purity, quality, efficacy and safety, has questioned their efficiency in treating various disorders. The present study was conducted to perform a quality audit of two herbal formulations, i.e., ashokarishta syrup and chandraprabha vati, of three different marketed brands. The quality auditing procedures included analysis of moisture content, ash value, pH, presence of heavy metals, pesticide residue, radioactive substances and microbial contamination. The formulations were pharmacologically evaluated for anti-inflammatory activity using the rat paw edema model. All the formulations passed the microbial contamination test. None of the heavy metals was detected with higher than permissible limits in any formulations. Moreover, all the formulations were found free from pesticides and radioactive substances. In addition, the formulations also possessed anti-inflammatory activity; however, their activity varied among brands. The present study concluded that all the formulations tested were successfully quality audited. This study can be used as a standardizing tool for the future perspective.
Keywords:
Ashokarishta syrup, Anti-inflammatory, Chandraprabha vati, Herbal formulations, Quality audit, StandardizationDOI
https://doi.org/10.25004/IJPSDR.2022.140513References
Adithan C. Pharmacological Research in India, 1972-1995: An Analysis Based on IPS Conferences. Indian J Pharmacol. 1996; 28:125-128.
Anand U, Tudu CK, Nandy S, Sunita K, Tripathi V, Loake GJ, Dey A, Proćków J. Ethnodermatological Use of Medicinal Plants in India: From Ayurvedic Formulations to Clinical Perspectives - A Review. J Ethnopharmacol. 2022; 284:114744.
Sharma AK, Pundarikakshudu K. Regulatory Aspects of Traditional Indian Medicines (TIM) in India and in International Purview. J AOAC Int. 2019; 102(4):993-1002.
Sarma N, Upton R, Rose U, Guo DA, Marles R, Khan I, Giancaspro G. Pharmacopeial Standards for the Quality Control of Botanical Dietary Supplements in the United States. J Diet Suppl. 2021; Oct 26:1-20 [E-pub ahead of print].
Nikam PH, Kareparamban J, Jadhav A, Kadam V. Future Trends in Standardization of Herbal Drugs. J Appl Pharm Sci. 2012; 02(06):38-44.
Koonrungsesomboon N, Morakote N, Karbwang J. Ethical Considerations and Challenges in Herbal Drug Trials with the Focus on Scientific Validity and Risk Assessment. Phytother Res. 2021; 35(5):2396-2402.
Makhija IK, Shreedhara CS, Ram HH. Physico-Chemical Standardization of Sitopaladi Churna. Anc Sci Life. 2012; 31(3):107-116.
Modi MB, Donga SB, Dei L. Clinical Evaluation of Ashokarishta, Ashwagandha Churna and Praval Pishti in the Management of Menopausal Syndrome. Ayu. 2012; 33(4):511-516.
Kumar T, Larokar YK, Jain V. Standardization of Different Marketed Brands of Ashokarishta: An Ayurvedic Formulation. J Sci Innov Res. 2013; 2(6):993-998.
Mishra AK, Singh R, Mishra K, Pathak MK. Quality Assessment of Different Marketed Brands of Ashokarishta: An Ayurvedic Formulation. Int J Pharm Pharm Sci. 2012; 4(2):506-508.
Saralla RP, Lavanya R, Sudha V, Brindha P. Quality Control Studies on Chandraprabha Vati. Int J Pharm Pharm Sci. 2014; 6(1):91-96.
Safiullah A, Rengarajan D, Pemiah B, Krishnaswamy S, Krishnan UM, Sethuraman S, Sekar RK. Preparation and Characterization of Chandraprabha Vati: An Ayurvedic Formulation. Int J Pharm Pharm Sci. 2012; 4(2):55-59.
Jamadagni PS, Jamadagni BS, Neogy M, Singh RK, Upadhyay SN, Hazra J. Punarnava Mandur: Toxicity Study of Classical Ayurvedic Formulation in Wistar Rats. Int J Res Ayurveda Pharm. 2013; 4(3):390-397.
Liang Y, Xu Q, Hong-Dong L, Cao D. Support Vector Machines and Their Application in Chemistry and Biotechnology. CRC Press: Florida, United States, 2016.
World Health Organization. Research Guidelines for Evaluating the Safety and Efficacy of Herbal Medicines. World Health Organization: Manila, Philippines, 1993.
Monika P, Chandraprabha M, Rangarajan A, Waiker P, Chidambara K. Challenges in Healing Wound: Role of Complementary and Alternative Medicine. Front Nutr. 2022; 8:791899.
Kumari A, Muthu SA, Prakash P, Ahmad B. Herbalome of Chandraprabha Vati, A Polyherbal Formulation of Ayurveda Prevents Fibrillation of Lysozyme by Stabilizing Aggregation-Prone Intermediate State. Int J Biol Macromol. 2020; 148:102-109.
Gandhi AJ, Shukla VJ. Establishment of Quality Function Deployment with Special Reference to Good Manufacturing Practice of Chandraprabha Vati. Ayu. 2018; 39(1):34-39.
Wanjari MM, Mishra S, Dey YN, Sharma D, Gaidhani SN, Jadhav AD. Antidiabetic Activity of Chandraprabha Vati - A Classical Ayurvedic Formulation. J Ayurveda Integr Med. 2016; 7(3):144-150.
Deswal G, Saini V. Quality Audit of Herbal Drugs - A Review. World J Pharm Res. 2011; 4(11):400-417.
Chanda S. Importance of Pharmacognostic Study of Medicinal Plants: An Overview. J Pharmacogn Phytochem. 2014;2(5):69-73.
Adom E, Ekuadzi E, Boakye-Gyasi E, Amponsah I. Pharmacognostic Evaluation of Three Apocynaceae Plants that Share the Same West African Local Names. Phytomed Plus. 2022; 2(1):100157.
Rasheed A, Reddy BS, Roja C. A Review on Standardisation of Herbal Formulation. Int J Phytother. 2012; 2(2):74-88.
Gupta M, Pharm M, Chaudhary P, Tawar M, Shrivastava B. Need & Scope of Standardization of Herbal Medicines - A Review. J Res Pharm Sci. 2021; 7(8):26-31.
De Smet PA. Health Risks of Herbal Remedies. Drug Saf. 1995; 13(2):81-93.
Zamir R, Islam N, Asraf A, Zakaria C. An Insight into Pathway and Health Risk Assessment of Toxic Metals in Herbal Medicine. J Chem. 2022; 2022:2610852.
Cohen EA, Reif DM, Slover R, Mullikin A, Little J. Children's Environmental Health: A Systems Approach for Anticipating Impacts from Chemicals. Int J Environ Res Public Health. 2020; 17(22):8337.
Salem NM, Ahmad R, Estaitieh H. Organochlorine Pesticide Residues in Dairy Products in Jordan. Chemosphere. 2009; 77(5):673-678.
Bedi JS, Gill JP, Kaur P, Sharma A, Aulakh RS. Evaluation of Pesticide Residues in Human Blood Samples from Punjab (India). Vet World. 2015; 8(1):66-71.
Gerzabek MH, Strebl F, Temmel B. Plant uptake of radionuclides in lysimeter experiments. Environ Pollut. 1998; 99(1):93-103.
Gautam A, Kashyap S, Sharma PK, Garg V, Visht S, Kumar N. Identification, Evaluation and Standardization of Herbal Drugs: A Review. Der Pharm Lett. 2010; 2(6):302-315.
Yang R, Yuan BC, Ma YS, Zhou S, Liu Y. The Anti-Inflammatory Activity of Licorice, A Widely Used Chinese Herb. Pharm Biol. 2017; 55(1):5-18.
Darwish RS, Abdulmunem OA, Khairy A, Ghareeb A, Yassin AM, Abdulmalek SA, Shawky E. Comparative Metabolomics Reveals the Cytotoxic and Anti-Inflammatory Discriminatory Chemical Markers of Raw and Roasted Colocynth Fruit (Citrullus colocynthis L.). RSC Adv. 2021; 11(59):37049-37062.
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